INT73500

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.37
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13) extracellular space (IL13) extracellular region (IL13)
cell-cell signaling (IL13) cytoplasm (IL13)
Anatomy Link Frequency
Th2 cells 1
eosinophils 1
IL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 501 100.00 Very High Very High Very High
fibrosis 39 96.44 Very High Very High Very High
Inflammation 293 96.32 Very High Very High Very High
alcohol 1 92.92 High High
Arthritis 2 92.56 High High
agonist 61 87.36 High High
tolerance 9 85.84 High High
vagus nerve 2 85.56 High High
aspirin 6 85.44 High High
adenocard 6 85.12 High High
Disease Link Frequency Relevance Heat
Metaplasia 12 99.86 Very High Very High Very High
Asthma 796 99.80 Very High Very High Very High
Occupational Lung Diseases 35 99.36 Very High Very High Very High
Reprotox - General 3 27 98.32 Very High Very High Very High
Infection 306 98.08 Very High Very High Very High
Hypersensitivity 125 98.08 Very High Very High Very High
Syndrome 36 97.52 Very High Very High Very High
Nephritis 1 96.52 Very High Very High Very High
Fibrosis 34 96.44 Very High Very High Very High
INFLAMMATION 309 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to characterize the involvement of IL13 and STAT6 polymorphisms, a new multivariate analysis was done.
Regulation (involvement) of IL13
1) Confidence 0.36 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.65 Pain Relevance 0.03
The authors showed that the T allele enhanced the IL13 promoter activity in primary human and murine CD4+ Th2 cells.
Regulation (activity) of IL13 in Th2 cells
2) Confidence 0.36 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.17 Pain Relevance 0.03
We thus defined the correlation groups, based on r squared values, in the 5q31 region surrounding the IL13 gene and the 12q13 region surrounding the STAT6 gene.
Regulation (surrounding) of IL13
3) Confidence 0.36 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.61 Pain Relevance 0
Addition of a neutralizing mAb to IL-4 receptor in primary cultures, supplemented or not with PGE2, prevents the development of IL-4-producing cells but does not abolish the effects of PGE2 on IL-10 and IL-13 as well as T helper (Th)1-associated cytokines.
Neg (not) Regulation (effects) of IL-13 associated with cytokine
4) Confidence 0.24 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.65 Pain Relevance 0.50
In contrast, ASA did not affect IL-13, interferon-gamma, and IL-2 expression.
Neg (not) Regulation (affect) of IL-13
5) Confidence 0.22 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.08 Pain Relevance 0.29
An assay with improved sensitivity for detecting serum IL13 showed no difference in the systemic levels of IL13 in symptomatic asthmatics compared with asymptomatic asthmatics and healthy controls (St Ledger et al., 2009).
Neg (no) Regulation (difference) of IL13 associated with occupational lung diseases
6) Confidence 0.21 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.67 Pain Relevance 0.29
These events ultimately lead to the release of important cytokines such as IL-4 and IL-13 critical for immunoglobulin E (IgE) production.
Regulation (critical) of IL-13 associated with cytokine
7) Confidence 0.19 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.68 Pain Relevance 0.29
Because of the importance of Th-2 cytokines, IL-4, IL-5, IL-9, and IL-13, strategies aimed at inhibiting their production or effects have been tried in human clinical trials (Table).
Regulation (importance) of IL-13 associated with cytokine
8) Confidence 0.11 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.66 Pain Relevance 0.41
These responses are mediated by multiple mechanisms with airway mucus metaplasia being dependent on the IL-13/IL-4R?
Regulation (dependent) of IL-13 associated with metaplasia
9) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.49 Pain Relevance 0.35
In an animal model of asthma there is increased IL-19 expression and transfer of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13, however, IL-19 up-regulated IL-13 in “asthmatic” mice [260].
Regulation (regulated) of IL-13 associated with asthma
10) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.55 Pain Relevance 0.21
Many elements of the allergic reaction, including the production of IgE antibodies and the recruitment and activation of eosinophils, depend on Type 2 cytokines, such as IL-4, IL-5, and IL-13.
Regulation (depend) of IL-13 in eosinophils associated with hypersensitivity and cytokine
11) Confidence 0.06 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.19 Pain Relevance 0.52
The elevation of IgE in these disorders may be due to dysregulation of the IL-4-IL-13 axis.
Regulation (dysregulation) of IL-13
12) Confidence 0.04 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 2.01 Pain Relevance 0.31
In our study, IL-4 was undetectable and IL-13 levels were not significantly different in any group in contrast to previous report in which cHSP60 specific IL-13 in PBMCs has been reported to be associated with the protective response [22].
Neg (not) Regulation (different) of IL-13
13) Confidence 0.03 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2412883 Disease Relevance 0.95 Pain Relevance 0.29

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