INT73501

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Context Info
Confidence 0.01
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.96
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RETNLB) extracellular region (RETNLB) molecular_function (RETNLB)
cellular_component (RETNLB)
Anatomy Link Frequency
T cells 3
macrophages 1
RETNLB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 41 100.00 Very High Very High Very High
Inflammatory mediators 2 100.00 Very High Very High Very High
cytokine 24 99.96 Very High Very High Very High
Pain 2 98.22 Very High Very High Very High
rheumatoid arthritis 1 86.60 High High
agonist 1 79.60 Quite High
corticosteroid 1 78.56 Quite High
adenocard 1 78.24 Quite High
headache 2 68.64 Quite High
Inflammatory response 6 26.56 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 50 100.00 Very High Very High Very High
Hypersensitivity 2 98.92 Very High Very High Very High
Fever 2 98.74 Very High Very High Very High
Increased Venous Pressure Under Development 2 98.54 Very High Very High Very High
Pain 2 98.22 Very High Very High Very High
Cancer 7 97.04 Very High Very High Very High
Necrosis 3 96.80 Very High Very High Very High
Appetite Loss 23 95.56 Very High Very High Very High
Disease 4 91.60 High High
Cardiovascular Disease 1 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This prevents the release of pro-inflammatory mediators that produce an allergic response.
Negative_regulation (prevents) of Localization (release) of pro-inflammatory associated with inflammatory mediators and hypersensitivity
1) Confidence 0.01 Published 2006 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 17319219 Disease Relevance 0.43 Pain Relevance 0.12
In addition to their capacity to induce pain, vasodilatation and fever, prostaglandins E (PGE) exert anti-inflammatory activities by inhibiting the release of pro-inflammatory cytokines by macrophages and T cells, and by increasing interleukin (IL)-10 production by macrophages.
Negative_regulation (inhibiting) of Localization (release) of pro-inflammatory in T cells associated with pain, inflammation, fever, increased venous pressure under development and cytokine
2) Confidence 0.01 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.72 Pain Relevance 0.53
One proposed mechanism of the anti-inflammatory action of fish oils is impairment of the release of acute phase proteins and pro-inflammatory cytokines, in particular C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-?
Negative_regulation (impairment) of Localization (release) of pro-inflammatory associated with necrosis, inflammation, cancer and cytokine
3) Confidence 0.01 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2984449 Disease Relevance 1.66 Pain Relevance 0.43
In addition to their capacity to induce pain, vasodilatation and fever, prostaglandins E (PGE) exert anti-inflammatory activities by inhibiting the release of pro-inflammatory cytokines by macrophages and T cells, and by increasing interleukin (IL)-10 production by macrophages.
Negative_regulation (inhibiting) of in macrophages Localization (release) of pro-inflammatory in T cells associated with pain, inflammation, fever, increased venous pressure under development and cytokine
4) Confidence 0.00 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.72 Pain Relevance 0.53
The PDE 4 family is particularly abundant in immunocompetent cells, where an increase of cAMP leads to the inhibition of the synthesis and release of pro-inflammatory mediators, cytokines and active oxygen species.
Negative_regulation (inhibition) of Localization (release) of pro-inflammatory associated with inflammatory mediators and cytokine
5) Confidence 0.00 Published 2000 Journal Eur J Med Chem Section Abstract Doc Link 10889326 Disease Relevance 0.42 Pain Relevance 0.22

General Comments

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