INT73502

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 154
Total Number 158
Disease Relevance 124.87
Pain Relevance 43.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
plasma 8
blood 5
monocytes 5
T-cell 4
knee 3
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3305 100.00 Very High Very High Very High
Inflammation 2784 100.00 Very High Very High Very High
Inflammatory mediators 158 100.00 Very High Very High Very High
antagonist 96 100.00 Very High Very High Very High
Arthritis 377 99.92 Very High Very High Very High
Electroencephalography 99 99.92 Very High Very High Very High
rheumatoid arthritis 362 99.74 Very High Very High Very High
Crohn's disease 108 99.64 Very High Very High Very High
Multiple sclerosis 293 99.56 Very High Very High Very High
corticosteroid 139 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3435 100.00 Very High Very High Very High
Encephalopathy 173 100.00 Very High Very High Very High
Blister 6 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 260 99.98 Very High Very High Very High
Stress 197 99.98 Very High Very High Very High
Disease 1233 99.96 Very High Very High Very High
Juvenile Chronic Polyarthritis 149 99.92 Very High Very High Very High
Atherosclerosis 69 99.92 Very High Very High Very High
Metabolic Syndrome 55 99.88 Very High Very High Very High
Keloid Scars 25 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation leads to the notion that elevation of IL-10 is a consequence of the increased inflammatory activity seen in ACS, which also is related to long-term outcome.
Positive_regulation (elevation) of IL-10 associated with acute coronary syndrome and inflammation
1) Confidence 0.69 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.75 Pain Relevance 0.05
One could speculate that during regular exercise, IL10 levels would be constantly elevated, thus reducing inflammation in the joint and hence reducing pain.
Positive_regulation (elevated) of IL10 in joint associated with pain and inflammation
2) Confidence 0.66 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3004403 Disease Relevance 0.85 Pain Relevance 0.56
A recent study discovered an increase in IL10 levels of synovial fluid after acute resistance exercise in patients with OA of the knee [51].
Positive_regulation (increase) of IL10 in knee associated with osteoarthritis
3) Confidence 0.66 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3004403 Disease Relevance 0.65 Pain Relevance 0.38
An increase in circulating levels of IL-10 is believed to contribute to immunosuppression caused by major surgery.
Positive_regulation (increase) of IL-10
4) Confidence 0.65 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.13 Pain Relevance 0.36
Stress induced IL-10 does not seem to be essential for early monocyte deactivation following cardiac surgery.
Positive_regulation (induced) of IL-10 in monocyte associated with stress
5) Confidence 0.65 Published 2003 Journal Cytokine Section Title Doc Link 14609565 Disease Relevance 0.17 Pain Relevance 0.43
Patients with hyperglycemia on admission to the ICU had increased levels of IL-6 and IL-10, although after multivariate analysis only IL-6 was associated with hyperglycemia [22].
Positive_regulation (increased) of IL-10 associated with hyperglycemia
6) Confidence 0.50 Published 2005 Journal Crit Care Section Body Doc Link PMC1414017 Disease Relevance 1.30 Pain Relevance 0.34
Additional adjustment for CRP and IL-6 (model 2) changed the mortality risk associated with high IL-10 to a non-significant level (adjusted odds ratio, 1.7; 95% confidence interval, 0.8 to 3.6) (p?
Positive_regulation (high) of IL-10
7) Confidence 0.50 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.77 Pain Relevance 0
The risk of MI associated with increased IL-10 was not significantly elevated after adjustment for the risk indicators in model 1 (table 2).
Positive_regulation (increased) of IL-10 associated with myocardial infarction
8) Confidence 0.50 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.81 Pain Relevance 0
An inhibitory effect on the ability of DC to mature from peripheral monocytes has been attributed to the presence of HIV-induced CD4+ CD25+ IL-10-secreting T regulatory cells (44).
Positive_regulation (induced) of IL-10 in monocytes associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.49 Published 2006 Journal Parasite Immunology Section Body Doc Link PMC1636681 Disease Relevance 0.93 Pain Relevance 0
A group of specific therapies are directed against the influx of inflammatory cells into the airways and lung parenchyma that occurs in COPD; these include agents directed against adhesion molecules and chemokines, as well as therapies to oppose tumour necrosis factor alpha and increase interleukin 10.
Positive_regulation (increase) of interleukin 10 in lung associated with chemokine, necrosis, pulmonary disease, inflammation, cancer and adhesions
10) Confidence 0.49 Published 2004 Journal Lancet Section Abstract Doc Link 15364192 Disease Relevance 1.14 Pain Relevance 0.34
IL10 induction between CD patients versus controls showed no statistically significant differences between the groups, with P-values of 0.6767; 0.3891; 0.2718 and 0.9829 for P1, P2, P7 and P8, respectively.
Positive_regulation (induction) of IL10 associated with crohn's disease
11) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.44 Pain Relevance 0.27
Plasma concentrations of epinephrine, norepinephrine, cortisol, IL-6 and IL-10 as well as monocyte surface expression of HLA-DR and their ex vivo capacity to release TNF-alpha after LPS stimulation were measured perioperatively.
Positive_regulation (measured) of IL-10 in Plasma
12) Confidence 0.47 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.36 Pain Relevance 0.52
The strong association between elevation of IL-10 and future events was significantly weakened only after adjustment for CRP and IL-6, which suggests that IL-10 holds similarly detailed prognostic information as other biomarkers of inflammation.
Positive_regulation (elevation) of IL-10 associated with inflammation
13) Confidence 0.47 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.47 Pain Relevance 0.08
The 1170 CC genotype weakly predicted increased plasma concentrations of IL-10 in patients (p?
Positive_regulation (increased) of IL-10 in plasma
14) Confidence 0.47 Published 2008 Journal Heart Section Abstract Doc Link PMC2564840 Disease Relevance 0.90 Pain Relevance 0.04
synthesis by activated monocytes/macrophages but also stimulatory effects such as B-cell growth and lipid accumulation in oxLDL (low density lipoprotein)-stimulated macrophages have been observed.7–11 In patients with ACS, low admission levels of IL-10 in serum samples have been associated with an increased risk of cardiovascular events and high IL-10 levels with a decreased risk.12–15 However, conflicting results have also been published.16 Therefore, the prognostic importance of IL-10 in patients with ACS is not well understood and a clinical consensus has not been reached.
Positive_regulation (increased) of IL-10 in B-cell associated with acute coronary syndrome
15) Confidence 0.47 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.88 Pain Relevance 0.23
Plasma levels of tumour necrosis factor (TNF), interferon-gamma(IFN-gamma) and also IFN-gamma/interleukin-10 ratios were increased and exhibited a linear trend with gradual augmentation of disease severity.
Positive_regulation (increased) of interleukin-10 in Plasma associated with necrosis, cancer and disease
16) Confidence 0.45 Published 2010 Journal Malar J Section Abstract Doc Link PMC2837053 Disease Relevance 1.97 Pain Relevance 0.20
The magnitude of IL-10 elevation in patients was correlated with the extent of systemic proinflammatory activity, as evaluated by plasma concentrations of CRP and IL-6, which may be a reflection of coronary plaque rupture, thrombosis and cardiac damage.
Positive_regulation (elevation) of IL-10 in plaque associated with rupture and thrombosis
17) Confidence 0.44 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.72 Pain Relevance 0.04
It has been observed recently that whereas women with uncomplicated obesity have increased serum levels of IL-10, those with the metabolic syndrome do not [36].
Positive_regulation (increased) of IL-10 associated with metabolic syndrome
18) Confidence 0.44 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.81 Pain Relevance 0.29
During and after strenuous physical exercise, indomethacin treatment blunted serum IL-6, and augmented TNF-alpha and IL-10.
Positive_regulation (augmented) of IL-10
19) Confidence 0.42 Published 2002 Journal Cytokine Section Abstract Doc Link 12242082 Disease Relevance 0.28 Pain Relevance 0.38
Three, 6, and 24 h after irradiation, the proopiomelanocortin and interleukin-10 mRNA levels in suction blister induced epidermal sheets were considerably upregulated as detected by semiquantitative reverse transcription-polymerase chain reaction.
Positive_regulation (upregulated) of interleukin-10 associated with blister
20) Confidence 0.41 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15009732 Disease Relevance 0.50 Pain Relevance 0.35

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