INT73503

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 14.60
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13) extracellular space (IL13) extracellular region (IL13)
cell-cell signaling (IL13) cytoplasm (IL13)
Anatomy Link Frequency
naive T cells 4
endothelial cells 2
esophagus 2
spleen 2
Th2 cells 2
IL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 513 100.00 Very High Very High Very High
Inflammation 323 100.00 Very High Very High Very High
chemokine 50 100.00 Very High Very High Very High
antagonist 84 87.88 High High
Inflammatory mediators 4 83.36 Quite High
Fibrositis 97 82.96 Quite High
qutenza 6 78.08 Quite High
Inflammatory marker 4 77.04 Quite High
tolerance 1 75.88 Quite High
headache 6 73.00 Quite High
Disease Link Frequency Relevance Heat
Asthma 358 100.00 Very High Very High Very High
INFLAMMATION 340 100.00 Very High Very High Very High
Disease 123 100.00 Very High Very High Very High
Nicotine Addiction 178 99.80 Very High Very High Very High
Hypersensitivity 43 99.70 Very High Very High Very High
Autoimmune Disease 18 99.50 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 444 99.40 Very High Very High Very High
Eosinophilic Esophagitis 106 99.16 Very High Very High Very High
Cancer 137 98.64 Very High Very High Very High
Necrosis 17 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.
Positive_regulation (levels) of Gene_expression (levels) of IL-13 in naive T cells associated with necrosis and cancer
1) Confidence 0.37 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.79 Pain Relevance 0.55
PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.
Positive_regulation (levels) of Gene_expression (production) of IL-13 in naive T cells associated with necrosis and cancer
2) Confidence 0.37 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.79 Pain Relevance 0.55
Together, these results indicate that ETS exposure augments the expression and secretion of IL-13 in allergic asthma.
Positive_regulation (augments) of Gene_expression (expression) of IL-13 associated with asthma and nicotine addiction
3) Confidence 0.33 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.78 Pain Relevance 0.28
It was shown that IL-13 levels were highly increased in patients with asthma (P < .005).
Positive_regulation (increased) of Gene_expression (levels) of IL-13 associated with asthma
4) Confidence 0.24 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.71 Pain Relevance 0.15
and low IL-13 are expected), and the latter arguing against TH2-like disease, such as asthma (where high IL-4 and IL-13 are expected).
Positive_regulation (arguing) of Gene_expression (expected) of IL-13 associated with asthma and disease
5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.87 Pain Relevance 0.39
It may be that epinephrine-induced enhancement of IL-13 production is more sensitive to the propranolol blocking.
Positive_regulation (enhancement) of Gene_expression (production) of IL-13
6) Confidence 0.16 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.30 Pain Relevance 0.35
Propranolol (Pro) and atenolol (Ate) at a concentration of 1 × 10-4 M did not affect the cell viability in the cultures (88 and 90%, respectively, while that of the medium control was 85%), nor induced production of IL-6, IL-8 or IL-13 (Fig. 3).
Neg (nor) Positive_regulation (induced) of Gene_expression (production) of IL-13
7) Confidence 0.12 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.17
plus epinephrine effect on IL-6, IL-8, and IL-13 expression suggesting that p38 plays an important role in signaling from both IL-1?
Positive_regulation (on) of Gene_expression (expression) of IL-13
8) Confidence 0.12 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.12 Pain Relevance 0.11
Recent studies have also shown that IL-13 is overexpressed in the esophagus of EoE patients [20-22].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IL-13 in esophagus associated with eosinophilic esophagitis
9) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.09 Pain Relevance 0
However, atenolol only significantly reduced the enhancing effect of epinephrine on IL-13 production (p < 0.05, Fig. 3C), but not on IL-6 or IL-8 production (Fig. 3A and 3B).


Neg (not) Positive_regulation (on) of Gene_expression (production) of IL-13
10) Confidence 0.10 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.19
In animals, IL-33 treatment induces the expression of IL-4, IL-5 and IL-13 in the lung [295] and intraperitoneal injection of IL-33 induces spleen eosinophilia [295].
Positive_regulation (induces) of Gene_expression (expression) of IL-13 in spleen associated with eosinophilia
11) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.28 Pain Relevance 0.09
Exposure of MØ to IL-4 or IL-13 elicits an ‘alternate type of activation’, as opposed to the classical activation induced by IFN?
Positive_regulation (by) of Gene_expression (Exposure) of IL-13
12) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.51 Pain Relevance 0.13
Cytokines such as IL-4 and IL-13 as well as IL-1 beta and TNF-?
Positive_regulation (as) of Gene_expression (Cytokines) of IL-13 associated with cytokine
13) Confidence 0.07 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 1.03 Pain Relevance 0.21
In contrast to Th1-mediated autoimmune disorders, allergic disorders are mediated by Th2 cells through the production of IL-4, IL-5, and IL-13.
Positive_regulation (mediated) of Gene_expression (production) of IL-13 in Th2 cells associated with autoimmune disease and hypersensitivity
14) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 1.66 Pain Relevance 0.35
-hydroxylation pathway, is a pro-inflammatory mediator that markedly stimulates the production of inflammatory cytokines/chemokines in endothelial cells, including IL-8, IL-13, IL-4, and prostaglandin E2 [81]. 20-HETE stimulates NF-?
Positive_regulation (stimulates) of Gene_expression (production) of IL-13 in endothelial cells associated with chemokine, inflammation and cytokine
15) Confidence 0.04 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.39 Pain Relevance 0.51
Further failures of antigen clearance may result from an imbalance in immune regulation, initially characterized by increased production of Th2 cytokines (IL-4, IL-13) and a lack of the proinflammatory mediators (VEGF, TNF-?
Positive_regulation (increased) of Gene_expression (production) of IL-13 associated with cytokine
16) Confidence 0.02 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.16 Pain Relevance 0.05
The association of a Th2 bias and risk for IRIS was evident with elevated IL-4 levels at baseline, elevated IL-13 levels on ART before IRIS events, and elevated IL-10 levels at IRIS events as well as an association between increased IL-10 levels at IRIS and subsequent death.
Positive_regulation (elevated) of Gene_expression (levels) of IL-13 associated with immune reconstitution inflammatory syndrome and death
17) Confidence 0.02 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.12 Pain Relevance 0.17

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