INT73508

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Context Info
Confidence 0.51
First Reported 1998
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 32
Total Number 35
Disease Relevance 19.67
Pain Relevance 7.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (ISYNA1) cytoplasm (ISYNA1)
Anatomy Link Frequency
CGCs 4
monocytes 4
astrocytes 4
macrophages 2
smooth muscle 2
ISYNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 122 100.00 Very High Very High Very High
agonist 10 99.88 Very High Very High Very High
COX2 4 99.76 Very High Very High Very High
Abeta 8 99.52 Very High Very High Very High
Inflammation 362 99.42 Very High Very High Very High
local anesthetic 2 99.32 Very High Very High Very High
Inflammatory response 28 98.52 Very High Very High Very High
cINOD 36 98.36 Very High Very High Very High
rheumatoid arthritis 66 96.60 Very High Very High Very High
Pain 32 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dengue 102 100.00 Very High Very High Very High
Gastritis 6 99.52 Very High Very High Very High
INFLAMMATION 510 99.42 Very High Very High Very High
Chronic Fatigue Syndrome 11 99.08 Very High Very High Very High
Death 37 98.84 Very High Very High Very High
Stress 175 98.80 Very High Very High Very High
Injury 71 98.76 Very High Very High Very High
Cv General 2 Under Development 17 98.52 Very High Very High Very High
Drug Induced Neurotoxicity 8 98.18 Very High Very High Very High
Cancer 47 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Improvement of gastritis is expressed not only in quantity but also in quality of gastritis, which is shown as the reduction of iNOS expression in the gastric mucosa.
Negative_regulation (reduction) of Gene_expression (expression) of iNOS associated with gastritis
1) Confidence 0.51 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12925154 Disease Relevance 0.84 Pain Relevance 0.21
Local anesthetics decrease the production of NO by inhibiting iNOS expression in macrophages and increase NO production in glial cells.
Negative_regulation (inhibiting) of Gene_expression (expression) of iNOS in glial cells associated with local anesthetic
2) Confidence 0.48 Published 2008 Journal J Anesth Section Abstract Doc Link 18500613 Disease Relevance 0.60 Pain Relevance 0.27
CBD (10(-6) to 10(-4) M) inhibited both nitrite production and iNOS protein expression induced by Abeta (1-42).
Negative_regulation (inhibited) of Gene_expression (expression) of iNOS associated with abeta
3) Confidence 0.48 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16490313 Disease Relevance 0.63 Pain Relevance 0.37
IkappaBalpha degradation, NF-kappaB activation, and iNOS expression were attenuated by parthenolide (3mg/kg), the active constituent of feverfew, an anti-inflammatory drug used for migraine treatment.
Negative_regulation (attenuated) of Gene_expression (expression) of iNOS associated with inflammation and migraine
4) Confidence 0.41 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.70 Pain Relevance 0.57
Intravenous anesthetics inhibit iNOS expression in macrophages and the liver.
Negative_regulation (inhibit) of Gene_expression (expression) of iNOS in liver
5) Confidence 0.35 Published 2008 Journal J Anesth Section Abstract Doc Link 18500613 Disease Relevance 0.59 Pain Relevance 0.27
INOS expression in activated monocytes was observed in 10 out of 21 patients with Dengue Fever and was absent in cells from ten healthy individuals.
Negative_regulation (absent) of Gene_expression (expression) of INOS in monocytes associated with dengue
6) Confidence 0.32 Published 2005 Journal BMC Infect Dis Section Abstract Doc Link PMC1208887 Disease Relevance 0.84 Pain Relevance 0
During acute Dengue Fever, iNOS expression in monocytes differed among patients probably due to individual variations.
Negative_regulation (differed) of Gene_expression (expression) of iNOS in monocytes associated with dengue
7) Confidence 0.32 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.80 Pain Relevance 0
DENV-Ag detection in infected cells after treatment with an iNOS inhibitor – NGMLA or with a NO donor – SNP
Negative_regulation (inhibitor) of Gene_expression (detection) of iNOS
8) Confidence 0.32 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.23 Pain Relevance 0
In parallel, cannabidiol has been described to have anti-inflammatory properties in acute models of inflammation but the possible inhibitory effect of cannabidiol on iNOS protein expression and nitrite production in the nitrosative stress induced by Abeta in neuronal cell-line is un-investigated.
Spec (possible) Negative_regulation (effect) of Gene_expression (expression) of iNOS in neuronal associated with stress, inflammation and abeta
9) Confidence 0.31 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16490313 Disease Relevance 0.80 Pain Relevance 0.43
Agents that inhibit iNOS or superoxide production can attenuate such intestinal injury.
Negative_regulation (inhibit) of Gene_expression (production) of iNOS associated with injury
10) Confidence 0.30 Published 2003 Journal Inflammopharmacology Section Abstract Doc Link 15035794 Disease Relevance 0.73 Pain Relevance 0.51
L-N(6)-(1-iminoethyl)lysine, a selective iNOS inhibitor, attenuates the NO signal, emphasizing the importance of enzymatic activity to delayed NO production. iNOS expression is preceded by significant nuclear factor kappa B (NF-kappaB) activity, as reflected by a reduction in the inhibitory protein-kappa-Balpha (IkappaBalpha) and activation of NF-kappaB after GTN infusion.
Negative_regulation (preceded) of Gene_expression (expression) of iNOS
11) Confidence 0.30 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.65 Pain Relevance 0.47
These results suggest that inhibition of COX-2 and iNOS expression by the CH2Cl2 fraction of AFW occurred via suppression of I?
Negative_regulation (inhibition) of Gene_expression (expression) of iNOS
12) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846352 Disease Relevance 0.26 Pain Relevance 0.10
This reduced tumoricidal capacity has been linked to reduced iNOS expression [48] and would be in keeping with the current data.
Negative_regulation (reduced) of Gene_expression (expression) of iNOS
13) Confidence 0.20 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.44 Pain Relevance 0.27
Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.
Negative_regulation (suppresses) of Gene_expression (expression) of iNOS associated with cox2
14) Confidence 0.17 Published 2006 Journal J Ethnopharmacol Section Title Doc Link 16203115 Disease Relevance 0.28 Pain Relevance 0.32
This suppression correlated with downregulated gene expression of iNOS and COX-2.
Negative_regulation (downregulated) of Gene_expression (expression) of iNOS
15) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846352 Disease Relevance 0.31 Pain Relevance 0.13
These results suggest that inhibition of COX-2 and iNOS expression by AFW partially occurred via suppression of I?
Spec (partially) Negative_regulation (inhibition) of Gene_expression (expression) of iNOS
16) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846352 Disease Relevance 0.36 Pain Relevance 0.15
Among the five AFW fractions, the CH2Cl2 fraction markedly reduced the gene expression of iNOS and COX-2.
Negative_regulation (reduced) of Gene_expression (expression) of iNOS
17) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846352 Disease Relevance 0.24 Pain Relevance 0.12
The results suggest that a) an intracellular inflammatory response in the white blood cells plays an important role in the pathophysiology of CFS; b) the inflammatory response in CFS is driven by the transcription factor NFkappabeta; c) symptoms, such as fatigue, pain, cognitive defects and the subjective feeling of infection, indicates the presence of a genuine inflammatory response in CFS patients; and d) CFS patients may be treated with substances that inhibit the production of COX-2 and iNOS.
Negative_regulation (inhibit) of Gene_expression (production) of iNOS in white blood cells associated with pain, cognitive disorder, chronic fatigue syndrome, inflammatory response, fatigue and infection
18) Confidence 0.15 Published 2007 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 17693978 Disease Relevance 1.61 Pain Relevance 0.34
Incubation of CGCs with the non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen or indomethacin, or with 15-deoxy-delta12,14 prostaglandin J2 (PGJ2) downregulates iNOS expression and reduces subsequent cell death.
Negative_regulation (downregulates) of Gene_expression (expression) of iNOS in CGCs associated with inflammation, cinod and death
19) Confidence 0.11 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10695726 Disease Relevance 0.92 Pain Relevance 0.58
Since in other cell types, both NSAIDs and PGJ2 can activate the peroxisome proliferator-activated receptor-gamma (PPARgamma) and downregulate cytokine levels and iNOS expression, and since CGCs express PPARgamma in vivo and in vitro, our data suggest that activation of CGC PPARgamma mediates iNOS suppression and reduced cell death.
Negative_regulation (downregulate) of Gene_expression (expression) of iNOS in CGCs associated with cinod, death and cytokine
20) Confidence 0.11 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10695726 Disease Relevance 0.89 Pain Relevance 0.57

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