INT73538

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf, Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
cytoplasm (Ngfr) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
neuronal 1
neurons 1
Ngf (Mus musculus)
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 100.00 Very High Very High Very High
bradykinin 3 100.00 Very High Very High Very High
Root ganglion neuron 1 100.00 Very High Very High Very High
Central nervous system 4 97.00 Very High Very High Very High
cytokine 8 93.28 High High
Inflammatory mediators 2 92.28 High High
Inflammation 9 86.20 High High
chemokine 1 74.88 Quite High
Lasting pain 1 69.28 Quite High
cINOD 1 22.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 100.00 Very High Very High Very High
Injury 7 97.28 Very High Very High Very High
INFLAMMATION 13 91.88 High High
Apoptosis 133 80.00 Quite High
Disease 127 67.64 Quite High
Cognitive Disorder 16 63.28 Quite High
Retinoblastoma 1 43.84 Quite Low
Aging 5 34.36 Quite Low
Stress 32 32.92 Quite Low
Carcinoma 1 20.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We now show that nerve growth factor but not brain-derived neurotrophic factor or neurotrophin-3 selectively increases the expression of bradykinin binding sites on cultured dorsal root ganglion neurons from adult mouse via p75NTR.
nerve growth factor Positive_regulation (increases) of p75NTR in neurons associated with ganglion cysts, nerve growth factor, root ganglion neuron and bradykinin
1) Confidence 0.41 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466406 Disease Relevance 0.10 Pain Relevance 0.38
NGF-mediated activation of both TrkA and p75, the latter being increased following brain damage, may promote neuronal survival through activation of NF-kB [182], which can also be directly induced by most of the cytokines.
NGF Positive_regulation (activation) of p75 in neuronal associated with cytokine
2) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.95 Pain Relevance 0.47

General Comments

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