INT73539

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.99
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf, Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
cytoplasm (Ngfr) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
oligodendrocyte 3
neuronal 1
nerve 1
Ngf (Mus musculus)
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 305 100.00 Very High Very High Very High
Lasting pain 1 98.40 Very High Very High Very High
Spinal cord 28 96.76 Very High Very High Very High
intrathecal 4 89.52 High High
bradykinin 3 89.44 High High
Root ganglion neuron 1 86.96 High High
Hippocampus 17 56.88 Quite High
Intracerebroventricular 6 53.60 Quite High
long-term potentiation 9 23.12 Low Low
Mechanosensation 2 20.96 Low Low
Disease Link Frequency Relevance Heat
Death 80 100.00 Very High Very High Very High
Pain 1 98.40 Very High Very High Very High
Apoptosis 141 95.64 Very High Very High Very High
Frailty 10 88.04 High High
Disease 169 87.24 High High
Ganglion Cysts 3 86.64 High High
Injury 205 84.48 Quite High
Targeted Disruption 23 73.52 Quite High
Necrosis 9 69.00 Quite High
Cancer 8 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the interaction of nerve growth factor with p75NTR is an important factor contributing to chronic pain conditions.
nerve growth factor Binding (interaction) of p75NTR in nerve associated with nerve growth factor and lasting pain
1) Confidence 0.45 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466406 Disease Relevance 0.19 Pain Relevance 0.39
In the absence of trkA, NGF binds to its low affinity receptor p75NTR, which is thought to be responsible for triggering death pathways [47].
NGF Binding (binds) of p75NTR associated with nerve growth factor and death
2) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.53 Pain Relevance 0.70
For example, pro-NGF does not bind TrkA, but causes cell death by binding to p75NTR [7,8].
NGF Binding (binding) of p75NTR associated with nerve growth factor and death
3) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.29 Pain Relevance 0.41
The common p75NTR also enhances binding of NGF to TrkA receptors to create high affinity binding sites (Kd~10-11 M), possibly by binding to different surfaces on the NGF dimer [6]. p75NTR can also bind precursor forms of the neurotrophins.
NGF Binding (binding) of p75NTR associated with nerve growth factor
4) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.29 Pain Relevance 0.34
Pro-NGF, which binds with high affinity to p75NTR, and NGF have been implicated in p75NTR-mediated oligodendrocyte death in the retina and spinal cord [48-51].
NGF Binding (binds) of p75NTR in oligodendrocyte associated with nerve growth factor, death and spinal cord
5) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.56 Pain Relevance 0.71
Pro-NGF, which binds with high affinity to p75NTR, and NGF have been implicated in p75NTR-mediated oligodendrocyte death in the retina and spinal cord [48-51].
Pro-NGF Binding (binds) of p75NTR in oligodendrocyte associated with nerve growth factor, death and spinal cord
6) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.56 Pain Relevance 0.72
Pro-NGF, which binds with high affinity to p75NTR, and NGF have been implicated in p75NTR-mediated oligodendrocyte death in the retina and spinal cord [48-51].
Pro-NGF Binding (affinity) of p75NTR in oligodendrocyte associated with nerve growth factor, death and spinal cord
7) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.56 Pain Relevance 0.72
Given the existence of a cross-talk between the apoptotic cascades activated by different apoptotic triggers and that their molecular components are involved in reciprocal modulation by the NGF signaling, we will first review the main molecular mechanisms underlying the control of neuronal survival and death by NGF/proNGF through their interaction with the TrkA and p75 receptors.
proNGF Binding (interaction) of p75 in neuronal associated with apoptosis and death
8) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.01 Pain Relevance 0

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