INT73544

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Context Info
Confidence 0.64
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 31.28
Pain Relevance 8.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Grm7) plasma membrane (Grm7) neurological system process (Grm7)
protein complex (Grm7) signal transducer activity (Grm7)
Anatomy Link Frequency
neurons 8
brain 5
cerebral cortex 3
neuronal 2
skin 2
Grm7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 196 100.00 Very High Very High Very High
cerebral cortex 100 99.68 Very High Very High Very High
Glutamate 186 97.74 Very High Very High Very High
agonist 105 97.36 Very High Very High Very High
antagonist 94 96.84 Very High Very High Very High
nMDA receptor 29 96.12 Very High Very High Very High
wide dynamic range 3 93.52 High High
Hyperalgesia 24 92.88 High High
Dorsal horn 7 92.76 High High
Inflammation 26 89.64 High High
Disease Link Frequency Relevance Heat
Brain Injury 1875 99.74 Very High Very High Very High
Injury 675 99.66 Very High Very High Very High
Pressure Volume 2 Under Development 275 98.84 Very High Very High Very High
Stroke 25 98.72 Very High Very High Very High
Hyperalgesia 25 98.00 Very High Very High Very High
Closed Head Injuries 25 97.60 Very High Very High Very High
Manic Depressive Disorder 250 94.44 High High
INFLAMMATION 23 89.64 High High
Nociception 21 84.72 Quite High
Disease 130 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No changes have been detected in the levels of expression of mGluR 1,2,4,5,7 subtype messenger RNA in spinal cords taken from hyperalgesic animals.
Gene_expression (expression) of mGluR 1,2,4,5,7 in spinal cords associated with hyperalgesia
1) Confidence 0.64 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466463 Disease Relevance 0.72 Pain Relevance 0.93
Millan et al. (2002), have demonstrated that subtypes of group III mGluRs are associated with specific patterns of Ca2+-channel expression in glutamate terminals. mGluR4 is associated with terminals bearing both N and P/Q-type channels and can inhibit both, while mGluR7 is expressed at terminals bearing predominantly N-type channels (Millan et al., 2002).
Gene_expression (expressed) of mGluR7 associated with glutamate
2) Confidence 0.37 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.08 Pain Relevance 0.17
Interestingly, the study by Zhou and colleagues also showed that in primary culture of hippocampal neurons treated with lithium or VPA, levels of the protein glutamate receptor metabotropic 7 (GRM7), one of the miR-34a targets, was increased thus showing that miR-34a might contribute to mediating the effect of lithium and VPA on GRM7 [158].


Gene_expression (levels) of GRM7 in neurons associated with glutamate receptor
3) Confidence 0.33 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.41 Pain Relevance 0.09
Interestingly, the study by Zhou and colleagues also showed that in primary culture of hippocampal neurons treated with lithium or VPA, levels of the protein glutamate receptor metabotropic 7 (GRM7), one of the miR-34a targets, was increased thus showing that miR-34a might contribute to mediating the effect of lithium and VPA on GRM7 [158].


Gene_expression (levels) of protein glutamate receptor metabotropic 7 in neurons associated with glutamate receptor
4) Confidence 0.33 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.41 Pain Relevance 0.09
Similar decreases of mGluR7 mRNA expression in the VB and Po were found at all time points, while mGluR3 mRNA expression was bilaterally increased in the reticular thalamic nucleus (Rt).
Gene_expression (expression) of mGluR7 mRNA in reticular thalamic nucleus
5) Confidence 0.24 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.16 Pain Relevance 0.34
Immunohistochemical experiments revealed the co-expression of mGlu5 receptor protein and betaIII tubulin in skin from naive rats, indicating the constitutive expression of mGlu5 receptors on peripheral neurones.
Gene_expression (expression) of mGlu5 receptor in skin
6) Confidence 0.11 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11077066 Disease Relevance 0.82 Pain Relevance 0.98
Previous studies have demonstrated that the metabotropic glutamate receptor subtype 5 (mGlu5 receptor) is expressed in the cell bodies of rat primary afferent neurones.
Gene_expression (expressed) of mGlu5 receptor associated with glutamate receptor
7) Confidence 0.11 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11077066 Disease Relevance 0.61 Pain Relevance 0.51
Immunohistochemical experiments revealed the co-expression of mGlu5 receptor protein and betaIII tubulin in skin from naive rats, indicating the constitutive expression of mGlu5 receptors on peripheral neurones.
Gene_expression (-) of mGlu5 receptor in skin
8) Confidence 0.09 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11077066 Disease Relevance 0.82 Pain Relevance 0.98
So far, mGlu4 and mGlu7 receptors have been identified on primary cultured rat astrocytes (Besong et al., 2002; Yao et al., 2005) and mGlu4 and mGlu8 receptors on rat brain microglia, which were devoid of mGlu7 receptor expression (Taylor et al., 2003).
Gene_expression (expression) of mGlu7 in brain
9) Confidence 0.02 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989582 Disease Relevance 0.14 Pain Relevance 0.10
Glial cells that also express mGluRs could be distinguished from neurons by their morphological difference.
Gene_expression (express) of mGluRs in Glial cells
10) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.18 Pain Relevance 0
To determine whether mGluRs are involved in the cellular processes and whether hypotension, as an additional insult, exacerbates brain injury or neuronal injury by changing the expression of mGluRs in the cerebral cortex, we studied the alteration of neuronal expression of mGluRs after DBI and DBI coupled with SBI in a rodent diffuse brain injury (DBI) model.


Gene_expression (expression) of mGluRs in cerebral cortex associated with pressure volume 2 under development, injury, cerebral cortex and brain injury
11) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 1.25 Pain Relevance 0.16
Expression of mGluRs
Gene_expression (Expression) of mGluRs
12) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 1.05 Pain Relevance 0
However, the expression of group II mGluR decreased when the expression of group I and III mGluRs increased in our study.
Gene_expression (expression) of mGluRs
13) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.68 Pain Relevance 0.12
In the present study, we used a rodent DBI model to determine whether hypotension exacerbates neuronal injury as a secondary brain insult (SBI) after traumatic brain injury (TBI) by changing the expression of metabotropic glutamate receptors (mGluRs) in the cerebral cortex.


Gene_expression (expression) of mGluRs in neuronal associated with pressure volume 2 under development, glutamate receptor, injury, cerebral cortex and brain injury
14) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2242800 Disease Relevance 1.33 Pain Relevance 0.18
The expression of group I mGluRs peaked at 24 hours, while the expression of the group III mGluRs peaked at 6 hours after injuries, which may reflect a self-protection first mechanism of the damaged neurons.
Gene_expression (expression) of mGluRs in neurons associated with injury
15) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2242800 Disease Relevance 1.62 Pain Relevance 0.13
Although there was a significant rise in the expression of group I and group III mGluRs (except mGluR6) and a decrease in the expression of group II mGluRs after DBI (P < 0.05), the changes were more severe when DBI was coupled with SBI (P < 0.05).
Gene_expression (expression) of mGluRs associated with brain injury
16) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2242800 Disease Relevance 1.68 Pain Relevance 0.14
Our previous study investigated the alteration of expression patterns of mGluRs after DBI alone.
Gene_expression (expression) of mGluRs associated with brain injury
17) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.87 Pain Relevance 0.24
In our present study, we systematically observed changes in the expression of the mGluRs after DBI and DBI with SBI in animals.
Gene_expression (expression) of mGluRs associated with brain injury
18) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 1.29 Pain Relevance 0.38
Although we observed a significant elevation in the expression of group I and group III mGluRs (except mGluR6, represented by the number of mGluR4 positive neurons in figure 4) and a decrease in the expression of group II mGluRs in the supraventricular cerebral cortex after DBI, the changes were more severe when DBI was coupled with SBI.
Gene_expression (expression) of mGluRs in cerebral cortex associated with cerebral cortex and brain injury
19) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 1.21 Pain Relevance 0.37
In the present study, the alteration of neuronal expression of mGluRs was studied on the Marmarou's impact acceleration model of closed head injury and the SBI model similar to that described by Ishige [24].
Gene_expression (expression) of mGluRs in head associated with closed head injuries
20) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 1.59 Pain Relevance 0

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