INT73555

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.57
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
Anatomy Link Frequency
plasma 1
bone marrow 1
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 4 96.04 Very High Very High Very High
aspirin 3 83.32 Quite High
cytokine 8 82.72 Quite High
dexamethasone 1 70.52 Quite High
Inflammation 21 63.92 Quite High
cINOD 1 61.16 Quite High
qutenza 1 25.00 Low Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 96.04 Very High Very High Very High
Death 8 83.44 Quite High
Malignant Neoplastic Disease 3 83.00 Quite High
Adhesions 11 77.40 Quite High
Injury 4 48.72 Quite Low
Necrosis 4 45.80 Quite Low
Cancer 19 45.44 Quite Low
Lymphatic System Cancer 12 5.00 Very Low Very Low Very Low
Atherosclerosis 7 5.00 Very Low Very Low Very Low
Mantle-cell Lymphoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators.
Negative_regulation (inhibited) of p65 subunit associated with inflammatory mediators
1) Confidence 0.41 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.28 Pain Relevance 0.21
In the study presented we added antisense RelA p65 and NF-?
Negative_regulation (presented) of RelA
2) Confidence 0.39 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0.11
A statistically significant reduction of nuclear p65 concentration was observed when human monocytes were exposed to plasma (dilution 1:1 with cell culture medium) obtained after intake of Pycnogenol compared to basal values (Figure 3).
Negative_regulation (reduction) of p65 in plasma
3) Confidence 0.16 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0 Pain Relevance 0
B subunits [28], exposure of Granta cells to 30 ┬ÁM parthenolide for 3 hours resulted in an approximately 5-fold decrease in p65 DNA binding activity (Fig. 6A).
Negative_regulation (decrease) of p65
4) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780735 Disease Relevance 0.22 Pain Relevance 0
Culture of bone marrow stromal cells in VP-16 resulted in reduced nuclear RelA (p65), a modest increase in nuclear NF-kappaB1 (p50), and reduced NF-kappaB binding to its DNA consensus sequence.
Negative_regulation (reduced) of nuclear RelA in bone marrow
5) Confidence 0.00 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.08 Pain Relevance 0

General Comments

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