INT73558

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Context Info
Confidence 0.23
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 23
Total Number 26
Disease Relevance 12.02
Pain Relevance 8.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
plasma 2
monocytes 1
striatum 1
synovium 1
T cell 1
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2082 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Enkephalin 9 99.84 Very High Very High Very High
action potential duration 46 99.52 Very High Very High Very High
Action potential 84 99.24 Very High Very High Very High
Inflammation 338 99.12 Very High Very High Very High
rheumatoid arthritis 73 98.94 Very High Very High Very High
Serotonin 26 98.40 Very High Very High Very High
chemokine 86 98.20 Very High Very High Very High
Inflammatory response 25 97.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Autolysis 1 99.90 Very High Very High Very High
Toxicity 839 99.26 Very High Very High Very High
Fatigue 12 99.16 Very High Very High Very High
INFLAMMATION 388 99.12 Very High Very High Very High
Disease 138 98.96 Very High Very High Very High
Rheumatoid Arthritis 74 98.94 Very High Very High Very High
Cancer 58 98.16 Very High Very High Very High
Necrosis 19 98.02 Very High Very High Very High
Affective Disorder 8 97.52 Very High Very High Very High
Autoimmune Disease 27 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Observation of bone that has been refrigerated for prolonged periods of time indicates that a slow process of protein autolysis may alter the collagen element.
Spec (may) Regulation (alter) of collagen element associated with autolysis
1) Confidence 0.23 Published 2008 Journal Clin Orthop Relat Res Section Body Doc Link PMC2505281 Disease Relevance 0.10 Pain Relevance 0
These results demonstrate that Ik-1 and Ik-2 proteins through their DNA binding act as positive regulators of ENK gene expression in the developing striatum and participate in regulating enkephalinergic differentiation.
Regulation (regulators) of Ik in striatum associated with enkephalin
2) Confidence 0.13 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17504264 Disease Relevance 0 Pain Relevance 0.66
Therefore changes in IK,CCh and ICa do not entirely explain the observed contractile response.
Regulation (changes) of IK
3) Confidence 0.05 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0 Pain Relevance 0.18
In addition, the constituents simultaneously modulated the ionic channel currents such as ICa, IK, IK1 and INa.
Regulation (modulated) of IK
4) Confidence 0.04 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0 Pain Relevance 0.24
There are some evidences that opioids could be members of the cytokine family and the regulation of immune and inflammatory responses is dependent on the functions of cytokines; therefore much effort should be placed on understanding the effect of morphine on cytokine activity.
Regulation (effect) of cytokine associated with inflammatory response, opioid, morphine and cytokine
5) Confidence 0.02 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 17582693 Disease Relevance 0.67 Pain Relevance 0.69
Due to the synergistic action of IK,CCh and ICa, it is impossible to provide exact quantitative estimates on the relative importance of IK,CCh and ICa in the negative inotropic effect of CCh, even though IK,CCh seems to be more important.
Regulation (importance) of IK
6) Confidence 0.02 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0.09 Pain Relevance 0.22
The QT interval is a reflection of the repolarization of action potential, which is mainly responsible for the modulation of IK.
Regulation (modulation) of IK associated with action potential
7) Confidence 0.02 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0.11 Pain Relevance 0.41
In normal cells the stimulation of system y+L activity upon incubation with rGM-CSF was fully attributable to the induction of SLC7A7 gene (Figure 7, Panel B), thus identifying this gene as a cytokine target.
Regulation (target) of cytokine associated with cytokine
8) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.05
We have found that: 1) system y+L activity is markedly lowered in monocytes and alveolar macrophages from the LPI patient, because of the prevailing expression of SLC7A7/y+LAT1 in these cells; 2) on the contrary, fibroblasts isolated from the same patient do not display the transport defect due to compensation by the SLC7A6/y+LAT2 isoform; 3) in both normal and LPI monocytes, GM-CSF induces the expression of SLC7A7, suggesting that the gene is a target of the cytokine; 4) GM-CSF-induced differentiation of LPI monocytes is comparable to that of normal cells, demonstrating that GM-CSF signalling is unaltered; 5) general and respiratory conditions of the patient, along with PAP-associated parameters, markedly improved after GM-CSF therapy through aerosolization.


Regulation (target) of cytokine in monocytes associated with pulmonary alveolar proteinosis and cytokine
9) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.21 Pain Relevance 0.05
However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis.
Spec (might) Regulation (modify) of cytokine associated with cancer, fatigue and cytokine
10) Confidence 0.01 Published 2008 Journal Nat. Rev. Cancer Section Abstract Doc Link 18846100 Disease Relevance 1.43 Pain Relevance 0.53
In the extracellular environment, proteases can regulate cytokine activity and provide a checkpoint for activation of latent factors, i.e., TGF?.
Regulation (regulate) of cytokine associated with cytokine
11) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.06 Pain Relevance 0.40
A power analysis leveraging what is known on biological variability or cytokine response can also select the appropriate number of animals to demonstrate a drug-related change in cytokine value.
Regulation (value) of cytokine associated with cytokine
12) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.23 Pain Relevance 0.20
The predose sampling is useful over longer studies to capture a shifting baseline or persistence of previous recorded changes in cytokine levels.
Regulation (changes) of cytokine associated with cytokine
13) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.48 Pain Relevance 0.21
Specificity of an inflammatory biomarker becomes difficult to attain when there are multiple mechanisms of toxicity and/or organ involvement that could affect cytokine values.
Regulation (affect) of cytokine associated with toxicity, inflammation and cytokine
14) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 1.42 Pain Relevance 0.51
These low concentrations and predominately local activity may produce little change in cytokine levels in the systemic circulation despite considerable local perturbation.
Neg (little) Regulation (change) of cytokine associated with cytokine
15) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.61 Pain Relevance 0.25
In particular, consideration will be given to (1) the underlying natural biology of cytokines, (2) analytical and methodological factors in biomarker qualification, (3) evaluation in the established preclinical in vivo study designs, and (4) relationship between changes in cytokine levels and association with morphological or functional manifestations of toxicity.
Regulation (changes) of cytokine associated with toxicity and cytokine
16) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.87 Pain Relevance 0.34
A final consideration is the strength of the relationship between changes in cytokine levels and the development of phenotypic or functional manifestations of toxicity.
Regulation (changes) of cytokine associated with toxicity and cytokine
17) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Abstract Doc Link PMC2923281 Disease Relevance 0.50 Pain Relevance 0.45
The TGN1412 anti-CD28 molecule exemplifies the most disastrous consequence of species differences in cytokine response.
Regulation (response) of cytokine associated with cytokine
18) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.30 Pain Relevance 0.38
The presence of soluble receptors is also a point of regulating cytokine activity.
Regulation (regulating) of cytokine associated with cytokine
19) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.42 Pain Relevance 0.60
The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown.
Regulation (regulation) of cytokine associated with cytokine
20) Confidence 0.01 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.53 Pain Relevance 0.26

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