INT73572

Context Info Confidence 0.67 First Reported 1998 Last Reported 2010 Negated 0 Speculated 3 Reported most in Body Documents 10 Total Number 13 Disease Relevance 6.60 Pain Relevance 1.00

extracellular space (S100A8) extracellular region (S100A8) plasma membrane (S100A8) cytoskeleton (S100A8) cytoplasm (S100A8)

Anatomy Link Frequency plaques 1 S100A8 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 14 100.00 peptic ulcer disease 12 99.52 nud 5 99.02 Inflammation 6 90.08 abdominal pain 8 68.20 Cluster headache 4 50.00 Angina 1 50.00 Bile 3 15.20 imagery 2 5.00 Chronic pancreatitis 1 5.00

Disease Link Frequency Relevance Heat Sprains And Strains 15 100.00 Cystic Fibrosis 14 100.00 Ulcers 28 99.92 Cancer 2 99.70 Dyspepsia 3 99.02 Disease 21 99.00 Infection 4 98.24 Exocrine Pancreatic Insufficiency 9 98.04 Gastroesophageal Reflux Disease 4 96.72 INFLAMMATION 7 96.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Patients with a cagA-positive genotype showed a significant increase in anti-cagA antibodies and also had significantly increased circulating levels of pepsinogen C.

Positive_regulation (increase) of cagA

1) Confidence 0.67 Published 1998 Journal Am. J. Gastroenterol. Section Body Doc Link 9468248 Disease Relevance 0.08 Pain Relevance 0

OBJECTIVE: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA.

Spec (whether) Positive_regulation (increased) of S100A8 in plaques

2) Confidence 0.67 Published 2008 Journal Heart Section Body Doc Link 18308864 Disease Relevance 0.19 Pain Relevance 0

However, pairwise comparisons of signal values showed upregulation of several S100 calcium binding proteins; S100A8 (calgranulin A), S100A12 (calgranulin C), and S100P during active phase of the disease compared to remission.

Positive_regulation (upregulation) of S100A8

3) Confidence 0.58 Published 2006 Journal Headache Section Body Doc Link 17115985 Disease Relevance 0 Pain Relevance 0

CONCLUSIONS: This is the first report exploring the relationship between circulating S100A8/A9 and acute appendicitis and establishes proof of concept for this biomarker as a diagnostic test for acute appendicitis.

Positive_regulation (circulating) of S100A8

4) Confidence 0.49 Published 2010 Journal Acad Emerg Med Section Body Doc Link 20370768 Disease Relevance 0.07 Pain Relevance 0

[Genotypying of clinical isolates of Helicobacter pylori by cagA, vacA and babA2 virulence associated genes.

Positive_regulation (virulence) of cagA associated with ulcers

5) Confidence 0.49 Published 2006 Journal Rev Med Chil Section Title Doc Link 17130985 Disease Relevance 0.65 Pain Relevance 0.09

The potential for CagA to disrupt the apical junctional barrier and for the outer membrane protein oipA to promote IL-8 secretion and gastric inflammation have also been explored.

Positive_regulation (potential) of CagA

6) Confidence 0.49 Published 2004 Journal Curr. Opin. Gastroenterol. Section Body Doc Link 15703688 Disease Relevance 0.15 Pain Relevance 0

CagA positive strains may induce severe gastroduodenal peptic ulcer disease.

Spec (may) Positive_regulation (induce) of CagA associated with peptic ulcer disease, disease and sprains and strains

7) Confidence 0.49 Published 2002 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 12352217 Disease Relevance 0.90 Pain Relevance 0.10

METHODS: DNA was isolated from an antral biopsy sample and vacA, cagA, and iceA genotype were determined by PCR and a reverse hybridization technique in 183 patients with culture-proven H. pylori infection: 51 with peptic ulcer disease (PUD), 62 with gastroesophageal reflux disease (GERD), and 70 with a normal endoscopy (gastritis only; GO).

Spec (determined) Positive_regulation (determined) of cagA

8) Confidence 0.49 Published 2001 Journal Am. J. Gastroenterol. Section Body Doc Link 11569682 Disease Relevance 0 Pain Relevance 0

The importance of vacA, cagA, and iceA genotypes of Helicobacter pylori infection in peptic ulcer disease and gastroesophageal reflux disease.

Positive_regulation (importance) of cagA associated with peptic ulcer disease, ulcers, gastroesophageal reflux disease, disease and infection

9) Confidence 0.49 Published 2001 Journal Am. J. Gastroenterol. Section Title Doc Link 11569682 Disease Relevance 0.49 Pain Relevance 0.10

Therefore, we suggest that nonulcer dyspepsia patients should also be tested for CagA status along with the tests for H. pylori status; and a positive CagA testing should be considered as an indication for eradication treatment.

Positive_regulation (tested) of CagA

10) Confidence 0.49 Published 2001 Journal Helicobacter Section Body Doc Link 11422473 Disease Relevance 0 Pain Relevance 0

CagA is tyrosine-phosphorylated and induces changes in the tyrosine phosphorylation state of distinct cellular proteins.

Positive_regulation (induces) of CagA

11) Confidence 0.49 Published 2000 Journal Science Section Abstract Doc Link 10688800 Disease Relevance 0.87 Pain Relevance 0.13

G542X is a Class I mutation that results in the complete failure to synthesize functional cystic fibrosis transmembrane conductance regulator (CFTR) and is usually associated with pancreatic insufficiency.

Positive_regulation (conductance) of cystic fibrosis associated with fibrosis, exocrine pancreatic insufficiency and cystic fibrosis

12) Confidence 0.49 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936924 Disease Relevance 1.37 Pain Relevance 0.34

Of these, 151/169 (89%) strains from patients with peptic ulcer, 73/83 (88%) strains from patients with non-ulcer dyspepsia and 8/9 (89%) strains from cancer patients were positive for the cagA gene.

Positive_regulation (positive) of cagA associated with cancer, ulcers, nud and sprains and strains

13) Confidence 0.45 Published 2000 Journal Microbios Section Abstract Doc Link 10885501 Disease Relevance 1.82 Pain Relevance 0.24

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