INT73575

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1998
Last Reported 2005
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 2.97
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ntsr1) plasma membrane (Ntsr1) signal transducer activity (Ntsr1)
Anatomy Link Frequency
body 2
Ntsr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 4 99.82 Very High Very High Very High
Pain 4 99.82 Very High Very High Very High
Opioid 1 99.50 Very High Very High Very High
Intracerebroventricular 2 98.70 Very High Very High Very High
Central grey 1 97.64 Very High Very High Very High
analgesia 7 96.88 Very High Very High Very High
Chronic pancreatitis 27 96.20 Very High Very High Very High
Neurotransmitter 1 90.92 High High
antinociception 2 90.64 High High
Morphine 1 87.68 High High
Disease Link Frequency Relevance Heat
Hypothermia 3 99.98 Very High Very High Very High
Pancreatic Cancer 27 97.72 Very High Very High Very High
Urological Neuroanatomy 1 97.64 Very High Very High Very High
Pancreatitis 30 96.20 Very High Very High Very High
Body Weight 2 94.64 High High
Congenital Anomalies 2 83.00 Quite High
Pain 1 64.96 Quite High
Cancer 18 48.80 Quite Low
Carcinoma 3 25.00 Low Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NT-1R(-/-) mice were hyperthermic; their body temperature was not affected by intracerebroventricular (i.c.v.) administration of NT, contrasting with the hypothermia induced in NT-1R(+/+) mice.
Positive_regulation (induced) of NT-1R in body associated with hypothermia and intracerebroventricular
1) Confidence 0.60 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384239 Disease Relevance 0.28 Pain Relevance 0.33
Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia.
Positive_regulation (inactivation) of neurotensin type 1 receptor in body associated with analgesic and analgesia
2) Confidence 0.50 Published 2002 Journal Brain Res. Section Title Doc Link 12384239 Disease Relevance 0.21 Pain Relevance 0.49
In the present study, we investigated whether this is due to NT receptor-1 (NTR-1) mRNA up-regulation and whether NTR-1 mRNA could also be used as a specific diagnostic marker and treatment target in pancreatic cancer.
Spec (whether) Positive_regulation (up-regulation) of NT receptor-1 associated with pancreatic cancer
3) Confidence 0.45 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 0.74 Pain Relevance 0.33
In the present study, we investigated whether this is due to NT receptor-1 (NTR-1) mRNA up-regulation and whether NTR-1 mRNA could also be used as a specific diagnostic marker and treatment target in pancreatic cancer.
Positive_regulation (used) of NTR-1 mRNA associated with pancreatic cancer
4) Confidence 0.45 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 0.75 Pain Relevance 0.34
In the present study, we investigated whether this is due to NT receptor-1 (NTR-1) mRNA up-regulation and whether NTR-1 mRNA could also be used as a specific diagnostic marker and treatment target in pancreatic cancer.
Spec (whether) Positive_regulation (up-regulation) of NTR-1 associated with pancreatic cancer
5) Confidence 0.45 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 0.74 Pain Relevance 0.33
Two CNS receptors, an opioid (mu) and a neurotensin (NTR-1), were targeted independently by repeated microinjection of PNAs into the periaqueductal gray.
Neg (independently) Positive_regulation (targeted) of NTR-1 associated with central grey and opioid
6) Confidence 0.06 Published 1998 Journal FEBS Lett. Section Abstract Doc Link 9468323 Disease Relevance 0.19 Pain Relevance 0.41
The first area concerns the functional activation of the high-affinity NT receptor, NTR-1, including the delineation of the NT binding pocket and receptor domains involved in functional coupling to intracellular signaling pathways.
Positive_regulation (activation) of NTR-1
7) Confidence 0.04 Published 2005 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 16003489 Disease Relevance 0.06 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox