INT73589

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.51
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
Mphi 2
p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 17 99.98 Very High Very High Very High
Hippocampus 1 99.80 Very High Very High Very High
Inflammation 4 82.80 Quite High
ischemia 4 75.00 Quite High
opiate 1 58.96 Quite High
addiction 1 58.40 Quite High
cerebral cortex 9 50.72 Quite High
metalloproteinase 17 43.24 Quite Low
Multiple sclerosis 1 39.00 Quite Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 1 99.98 Very High Very High Very High
Apoptosis 87 99.52 Very High Very High Very High
Cancer 8 98.20 Very High Very High Very High
Hepatocellular Cancer 5 97.58 Very High Very High Very High
Neointima 8 95.76 Very High Very High Very High
Retinoblastoma 1 93.80 High High
Natriuresis 3 88.96 High High
Reprotox - General 1 1 86.00 High High
INFLAMMATION 5 83.52 Quite High
Adhesions 7 81.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mohd Yusof et al. determine the antiproliferative and apoptosis effects of hot water extract of Chlorella vulgaris on the hepatoma cell line, HepG2 and conclude that it may have anticancer effects possibly by inducing apoptosis signaling cascades via increased expression of P53, Bax and caspase?
Positive_regulation (increased) of Gene_expression (expression) of P53 associated with hepatocellular cancer and apoptosis
1) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020329 Disease Relevance 0.82 Pain Relevance 0.07
In the adult rat hippocampus, seizure leads to the co-localized expression of p53 and Fas in CA1 neurons [36].
Positive_regulation (leads) of Gene_expression (expression) of p53 in neurons associated with convulsion and hippocampus
2) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.92 Pain Relevance 0.08
Morphine promoted the synthesis of Bax and p53 proteins by Mphi.
Positive_regulation (promoted) of Gene_expression (synthesis) of p53 in Mphi associated with morphine
3) Confidence 0.07 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9469450 Disease Relevance 0.73 Pain Relevance 1.44
overexpression of wild-type p53 both induced apoptosis and inhibited SMC migration resulting in a reduction in lesion formation [51].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with apoptosis
4) Confidence 0.03 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.04 Pain Relevance 0.08

General Comments

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