INT73590

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.94
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
pulmonary artery 2
Casp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 17 99.00 Very High Very High Very High
opiate 1 87.36 High High
addiction 1 86.80 High High
antagonist 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Hypoxia 2 99.98 Very High Very High Very High
Apoptosis 9 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 7 99.24 Very High Very High Very High
Pulmonary Hypertension 59 80.96 Quite High
Primary Pulmonary Hypertension 1 78.24 Quite High
Eisenmenger Complex 4 74.88 Quite High
Syndrome 1 72.16 Quite High
Limited Scleroderma 1 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effector phase of morphine-induced apoptosis appears to proceed through the accumulation of Bax and activation of ICE-1.
Positive_regulation (accumulation) of Positive_regulation (activation) of ICE-1 associated with apoptosis and morphine
1) Confidence 0.19 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9469450 Disease Relevance 0.69 Pain Relevance 1.28
All three agents induced vasorelaxation in pulmonary artery rings precontracted with phenylephrine, but only tadalafil significantly attenuated hypoxia-induced vasoconstriction and significantly attenuated hypoxia-induced upregulation of tumor necrosis factor alfa and interleukin-1 beta messenger RNA.
Positive_regulation (induced) of Positive_regulation (upregulation) of interleukin-1 beta messenger RNA in pulmonary artery associated with necrosis, cancer, hypoxia and increased venous pressure under development
2) Confidence 0.08 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012445 Disease Relevance 1.25 Pain Relevance 0

General Comments

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