INT73591

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Context Info
Confidence 0.07
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.74
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 17 99.98 Very High Very High Very High
tolerance 213 97.28 Very High Very High Very High
nMDA receptor 2 88.92 High High
cerebral cortex 20 86.56 High High
antagonist 7 85.44 High High
opiate 1 77.36 Quite High
addiction 2 76.80 Quite High
ischemia 135 71.12 Quite High
Inflammation 7 66.92 Quite High
Inflammatory mediators 1 65.48 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 163 100.00 Very High Very High Very High
Suicidal Behaviour 54 98.32 Very High Very High Very High
Neuroblastoma 2 77.52 Quite High
Cv Unclassified Under Development 123 71.12 Quite High
Neurodegenerative Disease 17 68.28 Quite High
INFLAMMATION 9 66.92 Quite High
Death 40 57.16 Quite High
Injury 13 50.96 Quite High
Necrosis 2 34.72 Quite Low
Cancer 10 34.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggest that morphine activates the induction phase of the apoptotic pathway through accumulation of p53.
Positive_regulation (activates) of Positive_regulation (accumulation) of p53 associated with apoptosis and morphine
1) Confidence 0.07 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9469450 Disease Relevance 0.73 Pain Relevance 1.38
In cerebral cortical neuroblasts, we have previously shown that estrogen promotes activation of the transcription factor p53, but uncouples p53 from down-stream cell suicide signals to promote neuronal survival [37].
Positive_regulation (promotes) of Positive_regulation (activation) of p53 in neuronal associated with suicidal behaviour
2) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.80 Pain Relevance 0.11
Since Fas expression was positively associated with p53 phosphorylation, it is likely that estrogen protection against apoptosis is contextual, i.e., dependent on the activation of p53.
Positive_regulation (dependent) of Positive_regulation (activation) of p53 associated with apoptosis
3) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.35 Pain Relevance 0.04
Anti-apoptotic mechanisms induced by PC are several: induction of Bcl-2, reductions in caspase-3 synthesis and p-53 activation, and reductions in mitochondrial cytochrome c [9,185].


Positive_regulation (induction) of Positive_regulation (activation) of p-53 associated with apoptosis
4) Confidence 0.01 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.87 Pain Relevance 0.55

General Comments

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