INT73592

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Context Info
Confidence 0.10
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 7.85
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
gonadal 1
cerebral cortex 1
p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 17 98.72 Very High Very High Very High
cerebral cortex 155 98.38 Very High Very High Very High
tolerance 213 94.96 High High
antagonist 52 89.88 High High
Hippocampus 20 89.32 High High
nMDA receptor 2 86.60 High High
opiate 1 77.36 Quite High
addiction 2 76.80 Quite High
ischemia 165 68.80 Quite High
Inflammation 7 64.60 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1273 99.78 Very High Very High Very High
Adhesions 68 99.44 Very High Very High Very High
Neurodegenerative Disease 137 99.28 Very High Very High Very High
Cancer 70 98.56 Very High Very High Very High
Suicidal Behaviour 459 98.32 Very High Very High Very High
Death 295 96.60 Very High Very High Very High
Convulsion 17 89.68 High High
Neuroblastoma 17 77.16 Quite High
Reprotox - General 1 17 75.72 Quite High
Cv Unclassified Under Development 138 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cerebral cortical neuroblasts, we have previously shown that estrogen promotes activation of the transcription factor p53, but uncouples p53 from down-stream cell suicide signals to promote neuronal survival [37].
Positive_regulation (activation) of p53 in neuronal associated with suicidal behaviour
1) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.80 Pain Relevance 0.11
We hypothesized that, in embryonic cerebral cortex, cell-surface Fas expression would be associated with exit from cell cycle, and activation of p53.
Positive_regulation (activation) of p53 in cerebral cortex associated with cerebral cortex
2) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.52 Pain Relevance 0.11
Since Fas expression was also associated with p53 activation, we hypothesized that estrogen would suppress Fas expression in the context of p53 activation as well.
Positive_regulation (activation) of p53
3) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.18 Pain Relevance 0.04
Thus, following p53 activation in our CHB50 cortical progenitors, we found that estrogen also led to a significant decrease in Fas expression.
Positive_regulation (activation) of p53
4) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.34 Pain Relevance 0.04
We had previously observed that estrogen prevented apoptosis in T-antigen-synchronized cultures, following p53 activation (as indicated by p53 phosphorylation at serine 392, and activation of prototypic p53-responsive genes like MDM2, p21/Waf-1 and Bax) [37].
Positive_regulation (activation) of p53 associated with apoptosis
5) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.41 Pain Relevance 0.03
These studies suggest that morphine activates the induction phase of the apoptotic pathway through accumulation of p53.
Positive_regulation (accumulation) of p53 associated with apoptosis and morphine
6) Confidence 0.10 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9469450 Disease Relevance 0.71 Pain Relevance 1.35
For example, we found that estrogen promotes p53 phosphorylation [37], but uncouples p53 from its regulation of Bax, a mitochondrial-associated pro-apoptotic factor.
Positive_regulation (promotes) of p53 associated with apoptosis
7) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.74 Pain Relevance 0.08
Activation of the transcription factor p53 was associated with induction of Fas expression, while the gonadal hormone estrogen antagonistically suppressed cell-surface Fas expression.
Positive_regulation (Activation) of p53 in gonadal
8) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.66 Pain Relevance 0.03
However, cessation of large T antigen expression (-tsTA, 39°C) is accompanied by induction of the p53 phosphorylation and the induction of p53-dependent proteins, p21/Waf1, Bax and MDM2 that lead to cell cycle-arrest, suicide, and p53 inhibition/cell cycle re-entry respectively.
Positive_regulation (induction) of p53 associated with suicidal behaviour
9) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.25 Pain Relevance 0
In the context of p53 activation, estrogen led to a significant decrease in the expression of Fas at 72 hours but not at 24 hours (Figure 8).
Positive_regulation (activation) of p53
10) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.20 Pain Relevance 0.09
We used phosphorylation of p53 at serine 392 as a marker for p53 activation [37].
Positive_regulation (activation) of p53
11) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.32 Pain Relevance 0
Fas expression in embryonic cortical-derived precursors is associated with p53 activation
Positive_regulation (activation) of p53
12) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.32 Pain Relevance 0
Estrogen prevents apoptosis following p53 activation and induces both neurogenesis and neuronal differentiation in this cell line.
Positive_regulation (activation) of p53 in neuronal associated with neurodegenerative disease and apoptosis
13) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.29 Pain Relevance 0
We had previously shown that p53 activation in cortical progenitor cells was associated with the induction of the mitochondrial death-associated protein Bax [37].
Positive_regulation (activation) of p53 associated with death
14) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.37 Pain Relevance 0
Since Fas expression was also associated with p53 activation, we hypothesized that estrogen would suppress Fas expression in the context of p53 activation as well.
Positive_regulation (activation) of p53
15) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.24 Pain Relevance 0.04
Phosphorylation of the casein kinase II-sensitive site at serine 392 was used as a marker for activated p53.
Positive_regulation (activated) of p53
16) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0 Pain Relevance 0
Fas expression is coincidentally increased following p53 activation.
Positive_regulation (activation) of p53
17) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.31 Pain Relevance 0.06
Since Fas expression was positively associated with p53 phosphorylation, it is likely that estrogen protection against apoptosis is contextual, i.e., dependent on the activation of p53.
Positive_regulation (activation) of p53 associated with apoptosis
18) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.34 Pain Relevance 0.04
Anti-apoptotic mechanisms induced by PC are several: induction of Bcl-2, reductions in caspase-3 synthesis and p-53 activation, and reductions in mitochondrial cytochrome c [9,185].


Positive_regulation (activation) of p-53 associated with apoptosis
19) Confidence 0.01 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.85 Pain Relevance 0.53

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