INT73594

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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2011
Negated 6
Speculated 3
Reported most in Body
Documents 61
Total Number 64
Disease Relevance 31.35
Pain Relevance 13.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (ISYNA1) cytoplasm (ISYNA1)
Anatomy Link Frequency
macrophages 18
plasma 6
platelet 6
chondrocytes 4
monocyte 4
ISYNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 128 100.00 Very High Very High Very High
Morphine 24 99.88 Very High Very High Very High
Abeta 4 99.84 Very High Very High Very High
qutenza 16 99.80 Very High Very High Very High
Inflammation 384 99.78 Very High Very High Very High
Inflammatory response 30 99.28 Very High Very High Very High
COX2 5 99.16 Very High Very High Very High
Migraine 37 99.04 Very High Very High Very High
Hippocampus 108 98.98 Very High Very High Very High
interstitial cystitis 10 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Familial Dysautonomia 121 100.00 Very High Very High Very High
Infection 157 99.88 Very High Very High Very High
INFLAMMATION 480 99.78 Very High Very High Very High
Disease 192 99.76 Very High Very High Very High
Stress 517 99.40 Very High Very High Very High
Injury 320 99.32 Very High Very High Very High
Dengue 102 99.20 Very High Very High Very High
Headache 51 99.04 Very High Very High Very High
Apoptosis 51 98.68 Very High Very High Very High
Anaplastic Astrocytoma 1 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium nitroprusside, an NO donor as well, also increases iNOS expression.
Positive_regulation (increases) of Gene_expression (expression) of iNOS
1) Confidence 0.55 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.45 Pain Relevance 0.31
The NO donor glyceryl trinitrate (GTN) provokes delayed migraine attacks when infused into migraineurs and also causes iNOS expression and delayed inflammation within rodent dura mater.
Positive_regulation (causes) of Gene_expression (expression) of iNOS in dura mater associated with inflammation and migraine
2) Confidence 0.48 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.46 Pain Relevance 0.32
Intraepithelial lymphocyte infiltration was increased in both duodenum and colon in AS patients compared to controls. iNOS activity in duodenum and colon and expression of iNOS protein in lamina propria inflammatory cells was increased in AS patients compared to controls.
Positive_regulation (increased) of in lamina Gene_expression (expression) of iNOS in colon
3) Confidence 0.44 Published 2003 Journal J. Rheumatol. Section Body Doc Link 14677189 Disease Relevance 0.18 Pain Relevance 0
Does the unfavorable pharmacokinetic and pharmacodynamic profile of the iNOS inhibitor GW273629 lead to inefficacy in acute migraine?
Positive_regulation (lead) of Gene_expression (profile) of iNOS associated with migraine
4) Confidence 0.42 Published 2009 Journal J Clin Pharmacol Section Title Doc Link 19246728 Disease Relevance 0.40 Pain Relevance 0.51
CBD (10(-6) to 10(-4) M) inhibited both nitrite production and iNOS protein expression induced by Abeta (1-42).
Positive_regulation (induced) of Gene_expression (expression) of iNOS associated with abeta
5) Confidence 0.41 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16490313 Disease Relevance 0.62 Pain Relevance 0.36
Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction.
Positive_regulation (inducible) of Gene_expression (expressions) of iNOS
6) Confidence 0.40 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.08 Pain Relevance 0
RESULTS: LPS markedly increased the expression of IL-1beta, iNOS and COX-2 genes.
Positive_regulation (increased) of Gene_expression (expression) of iNOS
7) Confidence 0.40 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.07 Pain Relevance 0
Volatile anesthetics mostly suppress, but in some instances may upregulate, the lipopolysaccharide-and cytokine-induced expression of iNOS in blood vessels and macrophages.
Positive_regulation (induced) of Gene_expression (expression) of iNOS in macrophages associated with cytokine
8) Confidence 0.38 Published 2008 Journal J Anesth Section Abstract Doc Link 18500613 Disease Relevance 0.48 Pain Relevance 0.27
Volatile anesthetics mostly suppress, but in some instances may upregulate, the lipopolysaccharide-and cytokine-induced expression of iNOS in blood vessels and macrophages.
Spec (may) Positive_regulation (upregulate) of Gene_expression (expression) of iNOS in macrophages associated with cytokine
9) Confidence 0.38 Published 2008 Journal J Anesth Section Abstract Doc Link 18500613 Disease Relevance 0.49 Pain Relevance 0.27
At 6 days of infection, the iNOS detection is increased as compared to that of 3 days and is coincident with the DENV decrease, favouring the hypothesis that iNOS+ cells were promoting an inhibitory effect on viruses either directly by NO production or by other virus-induced mechanisms during this monocyte activation, such as IFN-?
Positive_regulation (increased) of Gene_expression (detection) of iNOS in monocyte associated with infection
10) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.33 Pain Relevance 0.06
Among 22 patients tested for iNOS expression (Figures 1H and 2B), 10 were positive as compared to controls (Figures 1G and 2B).
Positive_regulation (tested) of Gene_expression (expression) of iNOS
11) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.63 Pain Relevance 0
We have exhibited here that DENV can be detected in peripheral monocytes of patients with acute Dengue Fever, and that these cells are activated as demonstrated by the expression of iNOS studied ex vivo.
Positive_regulation (demonstrated) of Gene_expression (expression) of iNOS in monocytes associated with dengue
12) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.84 Pain Relevance 0
Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase.
Positive_regulation (induction) of Gene_expression (Antagonism) of iNOS in vein endothelium associated with morphine
13) Confidence 0.34 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 9641464 Disease Relevance 0.18 Pain Relevance 0.31
Increased activity and expression of iNOS in human duodenal enterocytes from patients with celiac disease.
Positive_regulation (Increased) of Gene_expression (expression) of iNOS in enterocytes associated with celiac disease
14) Confidence 0.31 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 12121878 Disease Relevance 0.57 Pain Relevance 0.09
Furthermore, immunoblotting revealed a trend toward increased iNOS expression in smooth muscle and mucosal strips from FIC cats but not from healthy cats.
Positive_regulation (increased) of Gene_expression (expression) of iNOS in smooth muscle
15) Confidence 0.31 Published 2005 Journal J. Urol. Section Body Doc Link 15643277 Disease Relevance 0.13 Pain Relevance 0
The production of nitric oxide (NO) by iNOS, which is stimulated by proinflammatory mediators, is involved in cartilage catabolism and should therefore be considered a potential target for therapeutic interventions.
Positive_regulation (stimulated) of Gene_expression (production) of iNOS in cartilage
16) Confidence 0.30 Published 2008 Journal Biomed Mater Eng Section Abstract Doc Link 18334727 Disease Relevance 0.35 Pain Relevance 0.20
Similarly, immunolabeling studies of DRGs from FIV-infected animals showed that macrophages were the principal sources of STAT-1 and iNOS protein production.
Positive_regulation (sources) of Gene_expression (production) of iNOS protein in macrophages
17) Confidence 0.28 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.29 Pain Relevance 0.09
Thus, in the current study we investigated whether inducible NO synthase (iNOS) mediated NO production is altered in the bladder of cats with a naturally occurring model of IC termed feline IC (FIC).
Spec (whether) Positive_regulation (mediated) of Neg (NO) Gene_expression (production) of iNOS in bladder associated with interstitial cystitis
18) Confidence 0.24 Published 2005 Journal J. Urol. Section Abstract Doc Link 15643277 Disease Relevance 0.55 Pain Relevance 0.46
In pathological situations circulating pro-inflammatory cytokines induce the expression of iNOS and ET-1 in smooth muscle cells, also downregulating endothelial eNOS expression, resulting in an elevated ET-1 production and a decrease of NO [18,39].
Positive_regulation (induce) of Gene_expression (expression) of iNOS in smooth muscle cells associated with inflammation and cytokine
19) Confidence 0.24 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.93 Pain Relevance 0.38
Induction of iNOS expression was demonstrated in fetal membranes in labour and in in-vitro studies [122].
Positive_regulation (Induction) of Gene_expression (expression) of iNOS
20) Confidence 0.20 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.42 Pain Relevance 0.10

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