INT73596

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 43
Total Number 45
Disease Relevance 40.97
Pain Relevance 9.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
MCF-7 6
MDA-MB-231 4
synovial cells 2
Mphi 2
adipose tissue 2
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 42 99.98 Very High Very High Very High
antagonist 25 99.96 Very High Very High Very High
palliative 5 98.28 Very High Very High Very High
opioid receptor 2 96.36 Very High Very High Very High
cINOD 46 95.68 Very High Very High Very High
narcan 2 95.52 Very High Very High Very High
dexamethasone 140 94.96 High High
aspirin 24 93.24 High High
COX-2 inhibitor 3 92.64 High High
withdrawal 8 92.44 High High
Disease Link Frequency Relevance Heat
Apoptosis 1261 100.00 Very High Very High Very High
Death 276 99.64 Very High Very High Very High
Obesity 123 99.28 Very High Very High Very High
Cancer 565 98.92 Very High Very High Very High
Breast Cancer 255 98.80 Very High Very High Very High
Disease 136 97.80 Very High Very High Very High
Alagille Syndrome 2 96.72 Very High Very High Very High
Malignant Neoplastic Disease 38 96.00 Very High Very High Very High
Helminth Infection 3 94.92 High High
Paralysis 1 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine-treated Jurkat cells also showed a decreased expression of bcl-2 and an enhanced expression of bax.
Positive_regulation (enhanced) of Gene_expression (expression) of bax associated with morphine
1) Confidence 0.67 Published 1999 Journal J. Leukoc. Biol. Section Abstract Doc Link 10534122 Disease Relevance 0.95 Pain Relevance 0.87
RESULTS: Our results showed that aspisol reduced viability of MDA-MB-231 cells in time- and dose- dependent fashions and induced apoptosis by increase of caspase-3 and bax expressions while decrease of COX-2 and bcl-2 expression in vitro.
Positive_regulation (increase) of Gene_expression (expressions) of bax in MDA-MB-231
2) Confidence 0.67 Published 2008 Journal Exp. Oncol. Section Body Doc Link 19112426 Disease Relevance 0.07 Pain Relevance 0
Therefore, finding new cytotoxic agents that are able to increase Bax expression or restore the ability of tumour cells to undergo apoptosis are vital.
Positive_regulation (increase) of Gene_expression (expression) of Bax associated with cancer and apoptosis
3) Confidence 0.64 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 1.09 Pain Relevance 0.14
Treatment with amygdalin increased expression of Bax, a pro-apoptotic protein, decreased expression of Bcl-2, an anti-apoptotic protein, and increased caspase-3 enzyme activity in DU145 and LNCaP prostate cancer cells.
Positive_regulation (increased) of Gene_expression (expression) of Bax associated with prostate cancer and apoptosis
4) Confidence 0.56 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.68 Pain Relevance 0.08
Expression levels of Bak and Bax, and the activation of caspases 3 and 7 in HUVECs significantly increased when treated with morphine.
Positive_regulation (increased) of Gene_expression (Expression) of Bax associated with morphine
5) Confidence 0.55 Published 2009 Journal Toxicology Section Abstract Doc Link 19070643 Disease Relevance 0.59 Pain Relevance 0.98
The expression of p53, p21, bax and caspase-3 increased in Tan-I-treated cells.
Positive_regulation (increased) of Gene_expression (expression) of bax
6) Confidence 0.49 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18949381 Disease Relevance 1.01 Pain Relevance 0.08
This study focused on the biological mechanisms of sensitivity and resistance to NCX 4040, highlighting that the cytotoxic action of this drug may be due to the hyperexpression of Bax, its translocation to the mitochondria, the release of Cytochrome C, and the activation of caspases-9 and -3, overall in a p53-independent manner.
Positive_regulation (activation) of Gene_expression (hyperexpression) of Bax
7) Confidence 0.49 Published 2006 Journal Apoptosis Section Abstract Doc Link 16699954 Disease Relevance 0.31 Pain Relevance 0.48
This study focused on the biological mechanisms of sensitivity and resistance to NCX 4040, highlighting that the cytotoxic action of this drug may be due to the hyperexpression of Bax, its translocation to the mitochondria, the release of Cytochrome C, and the activation of caspases-9 and -3, overall in a p53-independent manner.
Spec (may) Positive_regulation (due) of Gene_expression (hyperexpression) of Bax
8) Confidence 0.49 Published 2006 Journal Apoptosis Section Abstract Doc Link 16699954 Disease Relevance 0.31 Pain Relevance 0.48
We observed that IR-induced bax and p21(WAF1/Cip1) protein expression were attenuated selectively in normal stromal and epithelial cell cultures, yet maintained their p53-dependency in malignant cell lines.
Positive_regulation (attenuated) of Gene_expression (expression) of bax in epithelial cell associated with malignant neoplastic disease
9) Confidence 0.49 Published 2003 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 12664070 Disease Relevance 0.91 Pain Relevance 0.10
A commitment to apoptosis was measured by examining any increase in the ratio of Bax (pro-apoptotic protein) expression to Bcl-2 (anti-apoptotic protein) expression.
Spec (examining) Positive_regulation (increase) of Gene_expression (expression) of Bax associated with apoptosis
10) Confidence 0.48 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.53 Pain Relevance 0.20
This finding is in accord with a recent report showing that stable overexpression of Bax-antagonist Bcl-2 in U937 cells reduces, but does not prevent, resveratrol-provoked death [36].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bax associated with antagonist and death
11) Confidence 0.48 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.88 Pain Relevance 0.37
However, although Bax overproduction in response to 100 ?
Positive_regulation (response) of Gene_expression (overproduction) of Bax
12) Confidence 0.48 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.94 Pain Relevance 0
In other model systems, Bax was overproduced in response to drugs, including resveratrol [10,14].
Positive_regulation (overproduced) of Gene_expression (overproduced) of Bax
13) Confidence 0.48 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 1.24 Pain Relevance 0.37
Although the mechanism for activating the expression and function of Bcl-2, Bcl-XL and Bax is not fully understood, it is possible that the p53 molecule plays a role in this process [30].
Positive_regulation (activating) of Gene_expression (expression) of Bax
14) Confidence 0.46 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 1.05 Pain Relevance 0.11
Since Bax expression was stimulated only at high resveratrol concentrations while Bax translocation and mitochondria-mediated cell death were observed also at low concentrations, we asked what relevance Bax might have for the chemopreventive activity of the compound.
Positive_regulation (stimulated) of Gene_expression (expression) of Bax associated with death
15) Confidence 0.44 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 1.14 Pain Relevance 0.35
The pro-apoptotic Bax protein is one of the major players in the mitochondrion form of apoptosis [26], and mitochondria-mediated cell death induced by resveratrol may involve stimulation of the expression of the bax gene by p53 or other transcription factors [10,14,27,28].
Positive_regulation (stimulation) of Gene_expression (expression) of bax associated with apoptosis and death
16) Confidence 0.44 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 1.26 Pain Relevance 0.08
The up-regulation of Bax protein expression suggests that 3HFD might be a potential anti-cancer agent in breast carcinoma.
Positive_regulation (regulation) of Gene_expression (expression) of Bax associated with cancer and breast cancer
17) Confidence 0.43 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 1.32 Pain Relevance 0.04
Our data demonstrate that 3HFD treatment down-regulated Bcl-2 and significantly up-regulated the expression of Bax in MCF-7 cells.
Positive_regulation (regulated) of Gene_expression (expression) of Bax in MCF-7
18) Confidence 0.43 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 0.99 Pain Relevance 0.13
Our results provide evidence that plant-derived 3HFD was able to induce the apoptotic cell death of MCF-7 cells by increasing Bax expression level and makes 3HFD a promising agent for chemotherapy, which merits further study.



Positive_regulation (increasing) of Gene_expression (expression) of Bax in MCF-7 associated with apoptosis and death
19) Confidence 0.43 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2873331 Disease Relevance 0.82 Pain Relevance 0
In addition, BV induces apoptosis in rheumatoid synovial cells through a decrease in BCL2 expression and an increase in BAX and caspase-3 (CASP3) expression.
Positive_regulation (increase) of Gene_expression (expression) of BAX in synovial cells associated with apoptosis
20) Confidence 0.41 Published 2005 Journal Toxicon Section Abstract Doc Link 15922390 Disease Relevance 1.03 Pain Relevance 0.27

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