INT73599

Context Info Confidence 0.55 First Reported 1997 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 47 Total Number 49 Disease Relevance 19.89 Pain Relevance 17.26

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)

Anatomy Link Frequency colon 4 skin 4 liver 2 brain 2 HGF 2 Cpox (Rattus norvegicus)

Pain Link Frequency Relevance Heat cINOD 156 99.96 dexamethasone 4 99.78 COX-2 inhibitor 34 99.64 electroacupuncture 18 99.64 cytokine 153 99.62 Inflammation 255 99.48 aspirin 60 99.32 agonist 22 99.32 Potency 20 99.28 Inflammatory response 25 99.20

Disease Link Frequency Relevance Heat Cancer 58 100.00 Functional Bowel Disorder 4 100.00 Rhinitis 3 99.88 Ulcers 27 99.86 Stress 59 99.76 INFLAMMATION 355 99.68 Injury 34 99.36 Disease 180 98.84 Hemorrhage 5 98.78 Peptic Ulcer 4 97.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Whereas paracetamol inhibited only COX enzyme activity, caffeine also inhibited COX-2 protein synthesis.

Negative_regulation (inhibited) of Gene_expression (synthesis) of COX associated with paracetamol

1) Confidence 0.55 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10963764 Disease Relevance 0 Pain Relevance 1.07

Sodium valproate, a mood stabilizer, when chronically administered to rats (200 mg/kg i.p. daily for 30 days) significantly reduced the brain protein levels of cyclooxygenase (COX)-1 and COX-2, without altering the mRNA levels of these enzymes.

Negative_regulation (reduced) of Gene_expression (levels) of COX in brain

2) Confidence 0.35 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694395 Disease Relevance 0 Pain Relevance 0

NSAIDs, retinoids, antioxidants, and PPAR agonists, reported to be chemopreventive, suppress COX-2 synthesis.

Negative_regulation (suppress) of Gene_expression (synthesis) of COX associated with agonist and cinod

3) Confidence 0.33 Published 2003 Journal FASEB J. Section Abstract Doc Link 12724337 Disease Relevance 0.38 Pain Relevance 0.25

Evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cycloxygenase (COX) and production of the proinflammatory prostaglandin, PGE2, and thus prevent carcinogenesis in the colon.

Negative_regulation (inhibit) of Gene_expression (production) of COX in colon associated with inflammation and cinod

4) Confidence 0.30 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 20225762 Disease Relevance 0.40 Pain Relevance 0.24

Dexamethasone treatment reduced the expression of both COX-2 and PGEs in kainate-treated animals.

Negative_regulation (reduced) of Gene_expression (expression) of COX associated with dexamethasone

5) Confidence 0.27 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.32 Pain Relevance 0.48

Moreover, ethanol fractions potently suppressed the expression of cycloxygenase (COX)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are stimulated by LPS in RAW264.7 cells.

Negative_regulation (suppressed) of Gene_expression (expression) of COX in granulocyte

6) Confidence 0.25 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688813 Disease Relevance 0.52 Pain Relevance 0.39

Although COX-1 mRNA was expressed in the colon without much alteration during the test period, the expression of COX-2 was upregulated with a peak on day 3 and decreased thereafter.

Negative_regulation (decreased) of Gene_expression (expression) of COX in colon

7) Confidence 0.24 Published 2006 Journal Digestion Section Abstract Doc Link 17143008 Disease Relevance 0.50 Pain Relevance 0.18

Yet all these agents inhibited not only the bacterial invasion but also the expression of COX-2 and iNOS activity in the intestinal mucosa following indomethacin treatment, resulting in the prevention of intestinal lesions.

Negative_regulation (inhibited) of Gene_expression (expression) of COX

8) Confidence 0.23 Published 2005 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 15610444 Disease Relevance 0 Pain Relevance 0

The data also showed that NF-kappaB activation and its associated gene expressions, such as COX-2, iNOS, VCAM-1 and ICAM-1, were all suppressed by the low dose aspirin supplementation through the inhibition of phosphorylation and degradation of IkappaBalpha via the NIK/IKK pathway.

Negative_regulation (suppressed) of Gene_expression (expressions) of COX associated with aspirin

9) Confidence 0.22 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16310244 Disease Relevance 0.60 Pain Relevance 0.59

By contrast, we found that LAE (0.02 microg/ml) selectively inhibited prostaglandin E2 production by cyclooxygenase (COX)-2, but not COX-1, which is a plausible mechanism for the analgesic effect.

Negative_regulation (inhibited) of Gene_expression (production) of COX associated with analgesic

10) Confidence 0.20 Published 2005 Journal Phytomedicine Section Abstract Doc Link 15693712 Disease Relevance 0.32 Pain Relevance 1.06

Non-steroidal anti-inflammatory drugs (NSAIDs) are thought to exert their pharmacological actions by a common mechanism: inhibition of cyclooxygenase (COX)-mediated prostanoid synthesis.

Negative_regulation (inhibition) of Gene_expression (synthesis) of COX associated with inflammation and cinod

11) Confidence 0.20 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19463915 Disease Relevance 0.60 Pain Relevance 0.64

High-dose flosulide treatment reduced renal prostaglandin production and caused a marked decline in COX-1 and COX-2 protein expression.

Negative_regulation (decline) of Gene_expression (expression) of COX

12) Confidence 0.19 Published 1999 Journal Kidney Int. Section Body Doc Link 10571785 Disease Relevance 0 Pain Relevance 0

Resveratrol also prevented the bilateralisation of COX-2 expression.

Negative_regulation (prevented) of Gene_expression (expression) of COX

13) Confidence 0.19 Published 2008 Journal Pain Section Abstract Doc Link 18814970 Disease Relevance 0.91 Pain Relevance 0.88

By contrast, we found that LAE (0.02 microg/ml) selectively inhibited prostaglandin E2 production by cyclooxygenase (COX)-2, but not COX-1, which is a plausible mechanism for the analgesic effect.

Negative_regulation (inhibited) of Gene_expression (production) of COX associated with analgesic

14) Confidence 0.18 Published 2005 Journal Phytomedicine Section Abstract Doc Link 15693712 Disease Relevance 0.32 Pain Relevance 1.05

The intestinal hypermotility caused by COX-1 inhibition may be a key to COX-2 expression after administration of NSAIDs and their intestinal ulcerogenic properties.

Negative_regulation (key) of Gene_expression (expression) of COX

15) Confidence 0.17 Published 2005 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 15610444 Disease Relevance 0 Pain Relevance 0

The expression of cyclooxygenase (COX)-1, COX-2, and inducible nitric oxide synthase (iNOS) was inhibited by 2 Hz EA in carrageenan-injected rat paws.

Negative_regulation (inhibited) of Gene_expression (expression) of COX associated with electroacupuncture

16) Confidence 0.16 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 17163587 Disease Relevance 1.09 Pain Relevance 0.94

Evaluation of 5-LOX metabolites-by LC/MS/MS and ELISA confirmed that both compounds selectively inhibited all products downstream of 5-hydroperoxy eicosatetraenoic acid (5-HPETE), including 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxoETE), without inhibition of 12-lipoxygenase (12-LOX), 15-lipoxygenase (15-LOX), or cyclooxygenase (COX) products.

Negative_regulation (inhibition) of Gene_expression (products) of COX

17) Confidence 0.15 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18295198 Disease Relevance 0.05 Pain Relevance 0.07

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and the local production of COX products that affect inflammation [1].

Negative_regulation (inhibit) of Gene_expression (production) of COX associated with inflammation and cinod

18) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1458335 Disease Relevance 0.64 Pain Relevance 0.43

The expression of cyclooxygenase (COX)-1, COX-2, and inducible nitric oxide synthase (iNOS) was inhibited by 2 Hz EA in carrageenan-injected rat paws.

Negative_regulation (inhibited) of Gene_expression (expression) of COX associated with electroacupuncture

19) Confidence 0.15 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 17163587 Disease Relevance 1.09 Pain Relevance 0.94

COX-1 expression in cortical collecting tubules was significantly reduced in G3 and G4 compared with G1 and G2 (P < 0.05 for all).

Negative_regulation (reduced) of Gene_expression (expression) of COX in collecting tubules

20) Confidence 0.14 Published 2009 Journal Int Urol Nephrol Section Body Doc Link 19031110 Disease Relevance 0.05 Pain Relevance 0

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