INT73602

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 30.66
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ager) plasma membrane (Ager) cytoplasm (Ager)
Anatomy Link Frequency
hearts 8
neurons 1
middle cerebral artery 1
cleavage 1
epithelial cells 1
Ager (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 240 99.98 Very High Very High Very High
Inflammation 1190 99.32 Very High Very High Very High
cytokine 281 96.60 Very High Very High Very High
Angina 6 89.08 High High
metalloproteinase 49 86.80 High High
Inflammatory response 54 86.52 High High
cINOD 20 85.68 High High
ischemia 130 79.32 Quite High
Inflammatory stimuli 20 55.44 Quite High
Inflammatory marker 21 50.44 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1524 100.00 Very High Very High Very High
Targeted Disruption 544 100.00 Very High Very High Very High
Myeloid Leukemia 287 100.00 Very High Very High Very High
Adhesions 178 99.90 Very High Very High Very High
Middle Cerebral Artery Infarction 20 99.76 Very High Very High Very High
INFLAMMATION 1265 99.32 Very High Very High Very High
Cancer 627 99.32 Very High Very High Very High
Sepsis 62 99.08 Very High Very High Very High
Stress 362 99.00 Very High Very High Very High
Age-related Macular Degeneration 8 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the RAGE receptor triggers signaling cascades leading to sustained cellular activation, increase of RAGE itself, and propagation of the response.
Positive_regulation (Activation) of RAGE receptor
1) Confidence 0.69 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.85 Pain Relevance 0.11
Consistent with increased AGE ligand levels in the diabetic heart, a significant increase in RAGE antigen by Western blotting was observed in diabetic compared with nondiabetic hearts (P < 0.05; Fig. 4A).
Positive_regulation (increase) of RAGE in hearts associated with diabetes mellitus
2) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.28 Pain Relevance 0
Diabetic BB/W hearts displayed increased RAGE antigen compared with nondiabetic hearts by immunohistochemistry (Fig. 1F and E, respectively) and Western blotting (P < 0.05; Fig. 1M).
Positive_regulation (increased) of RAGE in hearts associated with diabetes mellitus
3) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.01 Pain Relevance 0
Consistent with increased AGE ligand levels in the diabetic heart, a significant increase in RAGE antigen by Western blotting was observed in diabetic compared with nondiabetic hearts (P < 0.05; Fig. 4A).
Positive_regulation (increase) of RAGE in hearts associated with diabetes mellitus
4) Confidence 0.45 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.28 Pain Relevance 0
I/R increased CML by 20% in wild-type diabetic hearts but not in RAGE-KO D and Tg DN MSR D.
Neg (not) Positive_regulation (increased) of RAGE-KO D in hearts associated with targeted disruption, myeloid leukemia and diabetes mellitus
5) Confidence 0.45 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 3.12 Pain Relevance 0
Caspase-3 activation (Fig. 8A) was significantly reduced in diabetic RAGE RAGE-KO, Tg DN PPET RAGE, and Tg DN MSR RAGE hearts versus diabetic wild-type hearts after I/R (P < 0.05).
Positive_regulation (activation) of RAGE-KO in hearts associated with targeted disruption and diabetes mellitus
6) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 2.46 Pain Relevance 0
Activation of the RAGE receptor triggers signaling cascades leading to sustained cellular activation, increase of RAGE itself, and propagation of the response.
Positive_regulation (increase) of RAGE
7) Confidence 0.40 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.83 Pain Relevance 0.10
LDH release was significantly less in the diabetic Tg DN PPET RAGE hearts versus wild-type hearts after I/R (P < 0.05; Fig. 6F).
Positive_regulation (less) of RAGE in hearts associated with targeted disruption and diabetes mellitus
8) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 2.05 Pain Relevance 0.04
Caspase-3 activation (Fig. 8A) was significantly reduced in diabetic RAGE RAGE-KO, Tg DN PPET RAGE, and Tg DN MSR RAGE hearts versus diabetic wild-type hearts after I/R (P < 0.05).
Positive_regulation (activation) of RAGE in hearts associated with targeted disruption and diabetes mellitus
9) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 2.47 Pain Relevance 0
These studies support that the ligands of RAGE, upregulated in the diabetic heart, play important roles in transducing the long-term impact of hyperglycemia.
Positive_regulation (upregulated) of RAGE in heart associated with hyperglycemia and diabetes mellitus
10) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.77 Pain Relevance 0.04
However, AGEs that are present extracellularly disrupt cellular adhesion and activate the AGE receptor (RAGE).
Positive_regulation (activate) of RAGE associated with adhesions
11) Confidence 0.15 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.84 Pain Relevance 0.05
Furthermore, this study demonstrates an increase in the expression of soluble receptor for advanced glycation endproduct (sRAGE) due to pretreatment with doxycycline.
Positive_regulation (increase) of sRAGE
12) Confidence 0.09 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0.48 Pain Relevance 0.16
Furthermore, AGE stimulated RAGE-mediated activation of cultured RPE cells in a dose-dependent manner.
Positive_regulation (stimulated) of RAGE-mediated
13) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.80 Pain Relevance 0
for AGE (RAGE) and the scavenger receptor A (SR-A), which is responsible for
Positive_regulation (for) of RAGE
14) Confidence 0.05 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.67 Pain Relevance 0.05
On neurons, Abeta activation of RAGE will generate oxidative stress and activate NF-KB.
Positive_regulation (activation) of RAGE in neurons associated with stress and abeta
15) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.75 Pain Relevance 0.54
B, MAP kinases, and adhesion molecules are noted following activation of RAGE.
Positive_regulation (activation) of RAGE associated with adhesions
16) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.97 Pain Relevance 0.13
AGE activation of RAGE is found in diabetes, neuodegeneration, and aging [168].
Positive_regulation (activation) of RAGE associated with aging and diabetes mellitus
17) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.67 Pain Relevance 0
None of the other nuclear HMG proteins have been shown to activate RAGE.
Positive_regulation (activate) of RAGE
18) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.13 Pain Relevance 0.03
S100B activation of RAGE upregulates IL-1?
Positive_regulation (activation) of RAGE
19) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.75 Pain Relevance 0
Subtle structural differences that lead to different biochemical properties (Ca++ and Zn++ binding and preferred oligomerization state) thus seem to lead to different abilities to activate RAGE.
Positive_regulation (activate) of RAGE
20) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.69 Pain Relevance 0.29

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