INT73608

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 9.58
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 2
colon 1
nociceptors 1
central nervous system 1
microglia 1
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 200 100.00 Very High Very High Very High
cytokine 126 100.00 Very High Very High Very High
neuralgia 9 100.00 Very High Very High Very High
Central nervous system 15 99.08 Very High Very High Very High
Peripheral nervous system 7 98.40 Very High Very High Very High
nociceptor 1 97.96 Very High Very High Very High
cva 10 97.60 Very High Very High Very High
intrathecal 1 97.02 Very High Very High Very High
Thermal hyperalgesia 2 96.96 Very High Very High Very High
Migraine 1 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 242 100.00 Very High Very High Very High
Cancer 16 99.80 Very High Very High Very High
Drug Induced Neurotoxicity 8 99.72 Very High Very High Very High
Colon Cancer 8 99.68 Very High Very High Very High
Necrosis 16 99.56 Very High Very High Very High
Stress 35 98.80 Very High Very High Very High
Toxicity 14 98.56 Very High Very High Very High
Autoimmune Disease 3 97.84 Very High Very High Very High
Cv General 4 Under Development 12 97.60 Very High Very High Very High
Synovitis 4 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rats were injected with LPS at doses of 0, 1, 10, 100, and 1000 microg/kg, and measures of both iNOS mRNA and protein showed a dose-dependent increase in expression.
Localization (measures) of iNOS mRNA
1) Confidence 0.75 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918551 Disease Relevance 0 Pain Relevance 0.36
High molecular weight exogenous hyaluronan was injected into rat TMJs, in which synovitis had already been induced artificially by carrageenan injection, and the morphological changes in the synovial membrane and the localization of iNOS and NF-?
Localization (localization) of iNOS associated with synovitis
2) Confidence 0.74 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998788 Disease Relevance 0.63 Pain Relevance 0.46
OBJECTIVE: This study characterizes the distribution of iNOS and TNF-alpha in the spinal nerve roots, dorsal root ganglia and sciatic nerve of Lewis rats during experimental autoimmune neuritis (EAN).
Localization (distribution) of iNOS in sciatic nerve
3) Confidence 0.70 Published 2010 Journal Neuroimmunomodulation Section Body Doc Link 19816058 Disease Relevance 0.29 Pain Relevance 0
Here, we investigated the effect of parthenolide on inducible NO synthase (iNOS) synthesis and NO release using primary rat microglia.
Neg (NO) Localization (release) of iNOS in microglia
4) Confidence 0.66 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12417429 Disease Relevance 0.37 Pain Relevance 0.31
Intrathecal (i.t.) administration of IL-1beta activates p38 mitogen-activated protein kinase (MAPK), and leads to induction of inducible nitric oxide synthase (iNOS) and release of nitric oxide (NO), which sensitizes the spinal nociceptors and produces thermal hyperalgesia and allodynia.
Localization (release) of iNOS in nociceptors associated with allodynia, thermal hyperalgesia, nociceptor and intrathecal
5) Confidence 0.66 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.68 Pain Relevance 0.85
The localization of iNOS protein was detected by immunohistochemistry.
Localization (localization) of iNOS protein
6) Confidence 0.65 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952320 Disease Relevance 0.26 Pain Relevance 0
Immunocytochemistry performed on teased nerve fibers and ultrastructural analysis showed that iNOS was localized in both inflammatory and Schwann cells, and the study of cell membrane permeability detected with fluorescent dyes showed a diffuse necrotic phenotype in the whole peripheral nervous system (PNS).
Localization (localized) of iNOS in nerve associated with peripheral nervous system and inflammation
7) Confidence 0.65 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15144861 Disease Relevance 1.04 Pain Relevance 0.69
This result is in agreement with immunolocalization of iNOS in rat colon tumors induced by azoxymethane (11).
Localization (immunolocalization) of iNOS in colon associated with colon cancer
8) Confidence 0.65 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.57 Pain Relevance 0.04
Distribution of inducible nitric oxide synthase and tumor necrosis factor-alpha in the peripheral nervous system of Lewis rats during ascending paresis and spontaneous recovery from experimental autoimmune neuritis.
Localization (Distribution) of inducible nitric oxide synthase in peripheral nervous system associated with necrosis, neuralgia, paresis, peripheral nervous system, experimental autoimmune neuritis, cancer and neuritis
9) Confidence 0.65 Published 2010 Journal Neuroimmunomodulation Section Title Doc Link 19816058 Disease Relevance 0.39 Pain Relevance 0.44
We have performed immunohistochemical staining in order to examine the expression and immunolocalization of iNOS.
Spec (examine) Localization (immunolocalization) of iNOS
10) Confidence 0.61 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.24 Pain Relevance 0
B immunoreactivity in each group shared the iNOS localization patterns of its group (Fig. 2A and B).
Localization (localization) of iNOS
11) Confidence 0.60 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998788 Disease Relevance 0.12 Pain Relevance 0.12
An immunohistochemical study was performed to examine the localization of iNOS-positive cells in the central nervous system.
Spec (examine) Localization (localization) of iNOS in central nervous system associated with central nervous system
12) Confidence 0.60 Published 1998 Journal Neurol. Res. Section Abstract Doc Link 9471107 Disease Relevance 0.76 Pain Relevance 0.51
Renal sections were used for histologic grading of renal injury and for immunohistochemical localization of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Localization (localization) of iNOS
13) Confidence 0.60 Published 2001 Journal Kidney Int. Section Body Doc Link 11380809 Disease Relevance 0.07 Pain Relevance 0
Peritoneal macrophages, collected from healthy rats treated or not by lipopolysaccharides (LPS), together with commercially available iNOS from mouse macrophages (50 U, CALBIOCHEM, France Biochem, Meudon, France), were used as iNOS activity control.


Neg (not) Localization (treated) of iNOS in macrophages
14) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0 Pain Relevance 0.09
Immunohistochemistry of iNOS and nNOS
Localization (Immunohistochemistry) of iNOS
15) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.07 Pain Relevance 0.07
Immunohistochemical localization of nitrotyrosine, iNOS, P-selectin, ICAM and IL-1
Localization (localization) of iNOS
16) Confidence 0.51 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.15 Pain Relevance 0
Thus, our study suggests that the inhibitions of iNOS, COX-2 expression, and TNF-alpha release by the methanol extract of the semen of Xanthium strumarium L. are achieved by blocking NF-kappaB activation, and that this is also responsible for its anti-inflammatory effects.
Localization (release) of iNOS in semen associated with inflammation
17) Confidence 0.42 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.69 Pain Relevance 0.25
Release of inflammatory cytokines, iNOS, ROS and NO may cause direct stress to neurons.
Localization (Release) of iNOS in neurons associated with stress, inflammation and cytokine
18) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 1.37 Pain Relevance 0.30
RESULTS: Cells with treatment 1 and 3 did not exhibit presence of iNOS.
Localization (presence) of iNOS
19) Confidence 0.27 Published 2000 Journal Mund Kiefer Gesichtschir Section Body Doc Link 11094520 Disease Relevance 0 Pain Relevance 0
The effect of dihydrocucurbitacin B on the synthesis, release, and activity of pro-inflammatory enzymes (elastase, cyclooxygenase-2, and nitric oxide synthase-2) as well as its effect on different mediators (tumor necrosis factor-alpha and interleukin-1beta) were determined.
Localization (release) of nitric oxide synthase-2 associated with necrosis, inflammation and cancer
20) Confidence 0.25 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443215 Disease Relevance 0.97 Pain Relevance 0.22

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