INT7361

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Context Info
Confidence 0.45
First Reported 1984
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.37
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
gonadotrophs 1
nucleus 1
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 43 100.00 Very High Very High Very High
Somatostatin 24 99.80 Very High Very High Very High
Endogenous opioid 2 99.56 Very High Very High Very High
opioid receptor 4 99.48 Very High Very High Very High
Opioid 3 94.88 High High
opiate 12 88.32 High High
Enkephalin 11 87.04 High High
Potency 2 85.52 High High
agonist 4 80.08 Quite High
Neuropeptide 1 77.84 Quite High
Disease Link Frequency Relevance Heat
Immunization 4 100.00 Very High Very High Very High
Ulcers 4 99.40 Very High Very High Very High
Stress 6 99.26 Very High Very High Very High
Hypoglycemia 1 88.48 High High
Peptic Ulcer 2 80.88 Quite High
Body Weight 1 78.08 Quite High
Aging 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the mechanism by which clonidine stimulates GH-secretion in vivo and in vitro, we studied its interaction with GHRH.
GHRH Binding (interaction) of associated with clonidine
1) Confidence 0.45 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2514051 Disease Relevance 0 Pain Relevance 0.62
An antiserum raised against human pancreatic growth hormone-releasing factor-(1-40) (hpGRF-40) was found to recognize the rat hypothalamic growth hormone-releasing factor (rhGRF): This antiserum, when given iv to adult male rats, completely abolished GH release induced by a synthetic rhGRF (0.2, 1 microgram/kg BW), and inhibited the physiological GH secretion over 2 days.
growth hormone-releasing factor Binding (recognize) of
2) Confidence 0.38 Published 1984 Journal Endocrinology Section Abstract Doc Link 6325138 Disease Relevance 0.08 Pain Relevance 0.15
Effects of passive immunization of growth hormone-releasing hormone and somatostatin on growth hormone secretion under conditions of high somatostatin tone.
growth hormone-releasing hormone Binding (immunization) of associated with immunization and somatostatin
3) Confidence 0.37 Published 1992 Journal Life Sci. Section Title Doc Link 1347904 Disease Relevance 0.18 Pain Relevance 0.33
The complementary, rather dramatic synergistic interaction of GHRP, GHRH, and dermorphin or GHRP, GHRH, and 2549 in releasing GH again strongly supports the independent actions of these compounds.
GHRH Binding (interaction) of
4) Confidence 0.36 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.54
The complementary, rather dramatic synergistic interaction of GHRP, GHRH, and dermorphin or GHRP, GHRH, and 2549 in releasing GH again strongly supports the independent actions of these compounds.
GHRH Binding (interaction) of
5) Confidence 0.36 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.54
High concentrations of GHRH may interact directly with LHRH receptors on gonadotrophs and thereby enhance the release of LH, FSH, and Dyn A1-13-IR.
GHRH Binding (interact) of in gonadotrophs
6) Confidence 0.35 Published 1987 Journal Endocrinology Section Abstract Doc Link 2879724 Disease Relevance 0 Pain Relevance 0.14
Interaction of clonidine and GHRH on GH secretion in vivo and in vitro.
GHRH Binding (Interaction) of associated with clonidine
7) Confidence 0.35 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 2514051 Disease Relevance 0 Pain Relevance 0.97
Administration of clonidine (once daily) associated with growth hormone-releasing hormone (twice daily) further increased the GH secretory indices.
growth hormone-releasing hormone Binding (associated) of associated with clonidine
8) Confidence 0.35 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7950970 Disease Relevance 0.13 Pain Relevance 0.41
An antiserum raised against human pancreatic growth hormone-releasing factor-(1-40) (hpGRF-40) was found to recognize the rat hypothalamic growth hormone-releasing factor (rhGRF): This antiserum, when given iv to adult male rats, completely abolished GH release induced by a synthetic rhGRF (0.2, 1 microgram/kg BW), and inhibited the physiological GH secretion over 2 days.
rhGRF Binding (recognize) of
9) Confidence 0.33 Published 1984 Journal Endocrinology Section Abstract Doc Link 6325138 Disease Relevance 0.08 Pain Relevance 0.15
Some GH responses, including those induced by insulin, do not appear to be mediated by GHRH.
GHRH Binding (mediated) of
10) Confidence 0.23 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3138280 Disease Relevance 0.09 Pain Relevance 0.29
CLON-induced GH release in this system was associated with increased GRF and decreased SRIF release, and the pattern was reversed by hGH.
GRF Binding (associated) of associated with somatostatin
11) Confidence 0.20 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0.08 Pain Relevance 0.29
The formation of gastric stress ulcers was studied as a function of interactions between thyrotropin releasing hormone (TRH) and endogenous opioids in the central amygdalar nucleus (CEA) in rats.
releasing hormone Binding (interactions) of in nucleus associated with stress, ulcers and endogenous opioid
12) Confidence 0.07 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1924893 Disease Relevance 0.73 Pain Relevance 0.38
A series of (GH)-releasing pentapeptides and hexapeptides (GHRP's), as well as rat (rGHRH) and human (hGHRH) growth hormone-releasing hormones were tested for preferential binding to specific opioid receptors.
rGHRH Binding (binding) of associated with opioid receptor
13) Confidence 0.01 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 2853311 Disease Relevance 0 Pain Relevance 0.65

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