INT73611

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 22
Disease Relevance 26.67
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (SCD) endoplasmic reticulum (SCD)
Anatomy Link Frequency
heart 4
uterus 1
internal 1
SCD (Homo sapiens)
Pain Link Frequency Relevance Heat
antinociception 3 99.96 Very High Very High Very High
narcan 3 99.96 Very High Very High Very High
beta blocker 147 99.84 Very High Very High Very High
antagonist 8 99.78 Very High Very High Very High
opioid receptor 2 99.56 Very High Very High Very High
Cannabinoid receptor 1 98.40 Very High Very High Very High
tolerance 8 96.32 Very High Very High Very High
palliative 5 96.12 Very High Very High Very High
Pain 63 95.36 Very High Very High Very High
Antinociceptive 2 94.56 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 562 100.00 Very High Very High Very High
Sickle Cell Anemia 137 100.00 Very High Very High Very High
Heart Rate Under Development 949 99.36 Very High Very High Very High
Arrhythmias 2 Under Development 55 99.28 Very High Very High Very High
Bradycardia 5 98.56 Very High Very High Very High
Disease 54 98.08 Very High Very High Very High
Heart Disease 97 97.76 Very High Very High Very High
Accessory Atrioventricular Bundle 5 97.72 Very High Very High Very High
Infarction 3 96.48 Very High Very High Very High
Cardiomyopathy 242 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ID therapy is recommended for primary prevention developments SCD in patients with ventricular fibrillation against a background of the acute miocardial infarction.
Negative_regulation (prevention) of SCD associated with arrhythmias 2 under development, infarction and myocardial infarction
1) Confidence 0.37 Published 2009 Journal Georgian Med News Section Abstract Doc Link 19359720 Disease Relevance 1.13 Pain Relevance 0.14
Regional Medical Center at Memphis (Tennessee) established an SCD unit and developed an inpatient care delivery model that decreases the burden of caring for SCD patients on its busy emergency department, improves SCD patients' satisfaction and access to timely quality care, and reduces the needless pain and suffering of SCD patients.
Negative_regulation (established) of SCD associated with sickle cell anemia, pain and emergencies
2) Confidence 0.30 Published 2008 Journal J Healthc Manag Section Abstract Doc Link 18856136 Disease Relevance 1.91 Pain Relevance 0.42
Both instruments showed acceptable internal consistency reliabilities in SCD (BDI: ?
Negative_regulation (reliabilities) of SCD in internal associated with sickle cell anemia
3) Confidence 0.26 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2894759 Disease Relevance 0.24 Pain Relevance 0.04
Despite the considerable evidence in children for reduced HRQOL in SCD, few studies have evaluated the impact of this disease on health related quality of life in adults [8-11].
Negative_regulation (reduced) of SCD associated with sickle cell anemia and disease
4) Confidence 0.21 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1253526 Disease Relevance 2.03 Pain Relevance 0.53
Given the pro-arrhythmic effects and adverse side effect profiles of most antiarrhythmic drugs, it is often impractical to use them for primary prevention of SCD.
Negative_regulation (prevention) of SCD associated with myocardial infarction
5) Confidence 0.21 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 1.58 Pain Relevance 0.03
Furthermore, the absolute risk reduction of SCD in the majority of patients with PVCs or NSVT may not warrant the cost of a $17,500 device [21].
Negative_regulation (reduction) of SCD associated with heart rate under development and myocardial infarction
6) Confidence 0.21 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 1.57 Pain Relevance 0
The Amiodarone Trials Meta-Analysis Investigators showed a 13% reduction in mortality and 29% reduction in SCD in patients with recent myocardial infarction or congestive heart failure treated with amiodarone versus placebo [26].
Negative_regulation (reduction) of SCD in heart associated with heart rate under development and myocardial infarction
7) Confidence 0.21 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 1.35 Pain Relevance 0.07
The AVID study in patients with history of sudden cardiac arrest (secondary prevention) showed a reduction of overall mortality and SCD incidence with ICDs as compared with amiodarone [15].
Negative_regulation (reduction) of SCD associated with heart rate under development and myocardial infarction
8) Confidence 0.21 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 1.24 Pain Relevance 0
Although the implantable cardioverter defibrillator (ICD) is now the primary therapy for preventing SCD, it is difficult to identify those patients who are susceptible to lethal ventricular tachyarrhythmias for primary prevention.
Negative_regulation (preventing) of SCD associated with heart rate under development and myocardial infarction
9) Confidence 0.17 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Abstract Doc Link PMC1513519 Disease Relevance 1.12 Pain Relevance 0
Despite a reduction in the incidence of SCD, primary prevention remains challenging, as SCD is the initial presentation of cardiac disease in many patients.
Negative_regulation (reduction) of SCD associated with heart disease and myocardial infarction
10) Confidence 0.15 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 1.90 Pain Relevance 0
They decrease mortality in patients post-myocardial infarction [18] and in heart failure [19], at least partially due to a reduction in the incidence of SCD.
Negative_regulation (reduction) of SCD in heart associated with heart rate under development and myocardial infarction
11) Confidence 0.15 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 1.75 Pain Relevance 0.17
The Amiodarone Trials Meta-Analysis Investigators showed a 13% reduction in mortality and 29% reduction in SCD in patients with recent myocardial infarction or congestive heart failure treated with amiodarone versus placebo [26].
Negative_regulation (reduction) of SCD in heart associated with heart rate under development and myocardial infarction
12) Confidence 0.15 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 1.33 Pain Relevance 0.04
Antibradycardia pacing decreases SCD not only by the removal of serious bradyarrhythmias but also by prevention of the occurrence of malignant ventricular tachyarrhythmias induced by bradyarrhythmia.
Negative_regulation (decreases) of SCD associated with heart rate under development, malignant neoplastic disease, bradycardia and myocardial infarction
13) Confidence 0.14 Published 1997 Journal Bratisl Lek Listy Section Abstract Doc Link 9471337 Disease Relevance 1.74 Pain Relevance 0.10
RFCA is effective and useful in the treatment and prevention of SCD, especially in supraventricular tachyarrhythmias related to dual or accessory atrioventricular pathways.
Negative_regulation (prevention) of SCD associated with accessory atrioventricular bundle, heart rate under development and myocardial infarction
14) Confidence 0.10 Published 1997 Journal Bratisl Lek Listy Section Abstract Doc Link 9471337 Disease Relevance 1.06 Pain Relevance 0.07
Antitachycardia pacing is used in the prevention of SCD only as a part of ICD device.
Negative_regulation (prevention) of SCD associated with myocardial infarction
15) Confidence 0.10 Published 1997 Journal Bratisl Lek Listy Section Abstract Doc Link 9471337 Disease Relevance 1.85 Pain Relevance 0.09
Heart transplantation is the last alternative of non-pharmacologic prevention of SCD.
Negative_regulation (prevention) of SCD in Heart associated with myocardial infarction
16) Confidence 0.10 Published 1997 Journal Bratisl Lek Listy Section Abstract Doc Link 9471337 Disease Relevance 0.98 Pain Relevance 0
There are some limitations in using this method in the prevention of SCD in ventricular tachyarrhythmias.
Negative_regulation (prevention) of SCD associated with heart rate under development and myocardial infarction
17) Confidence 0.10 Published 1997 Journal Bratisl Lek Listy Section Abstract Doc Link 9471337 Disease Relevance 1.37 Pain Relevance 0.08
Deferasirox has also demonstrated dose-dependent efficacy in the SCD population.23 In one Phase II study in adult and pediatric patients, LIC was significantly reduced from baseline after 1 year of deferasirox treatment (P < 0.05).23 Serum ferritin levels were also decreased, although there was substantial intrapatient variability.
Negative_regulation (reduced) of SCD associated with sickle cell anemia
18) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2773754 Disease Relevance 0.87 Pain Relevance 0
The selective central cannabinoid receptor antagonist SR141716A, but not the generic opioid receptor antagonist naloxone, blocked the delta9-THC antinociception.
Negative_regulation (blocked) of delta9-THC associated with antinociception, cannabinoid receptor, antagonist, narcan and opioid receptor
19) Confidence 0.06 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10696800 Disease Relevance 0.42 Pain Relevance 1.65
Because the placenta lacks desaturase activity and fetal enzyme activity in uterus is very limited, the fetus depends on placental LC-PUFA transfer [6].
Negative_regulation (lacks) of desaturase in uterus
20) Confidence 0.04 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2707376 Disease Relevance 0.06 Pain Relevance 0.03

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