INT7362

Context Info Confidence 0.78 First Reported 1980 Last Reported 2011 Negated 10 Speculated 4 Reported most in Abstract Documents 185 Total Number 189 Disease Relevance 41.73 Pain Relevance 111.37

extracellular space (Sst) extracellular region (Sst)

Anatomy Link Frequency neurons 24 dorsal root ganglia 15 spinal cord 8 brain 8 RVLM 6 Sst (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 1224 100.00 Neuropeptide 302 100.00 substance P 257 100.00 Enkephalin 215 100.00 Calcitonin gene-related peptide 174 100.00 Pain 133 100.00 Cholecystokinin 111 100.00 Neurotransmitter 89 100.00 Dopamine 67 100.00 Root ganglion neuron 44 100.00

Disease Link Frequency Relevance Heat Ganglion Cysts 96 100.00 Increased Venous Pressure Under Development 16 100.00 Natriuresis 7 100.00 Fever 3 99.96 Cancer 23 99.88 Generalized Anxiety Disorder 9 99.88 Pain 141 99.84 Urological Neuroanatomy 51 99.84 Nociception 42 99.72 Rheumatoid Arthritis 17 99.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PCR data show that sst(1), sst(2(a)), sst(2(b)), sst(3), and sst(4) receptors are expressed in lumbar dorsal root ganglia of the rat.

Gene_expression (expressed) of sst in dorsal root ganglia

1) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219682 Disease Relevance 0.55 Pain Relevance 0.43

PCR data show that sst(1), sst(2(a)), sst(2(b)), sst(3), and sst(4) receptors are expressed in lumbar dorsal root ganglia of the rat.

Gene_expression (expressed) of sst in dorsal root ganglia

2) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219682 Disease Relevance 0.56 Pain Relevance 0.44

The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats.

Gene_expression (expression) of somatostatin in dorsal root ganglion associated with ganglion cysts, nociceptor, root ganglion neuron and somatostatin

3) Confidence 0.78 Published 2004 Journal Neuroscience Section Title Doc Link 15219682 Disease Relevance 0.46 Pain Relevance 0.62

Immunohistochemistry showed that a similar high proportion of neuronal profiles expressed sst(2(b)) receptor-like IR in control and AIA rats, but the proportion of neuronal profiles with sst(2(a)) receptor-like IR was significantly lower in acute and chronic AIA rats than in control rats.

Spec (like) Gene_expression (expressed) of sst in neuronal associated with arthritis

4) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219682 Disease Relevance 0.73 Pain Relevance 0.55

The sst(5) receptor was expressed in a few samples.

Gene_expression (expressed) of sst

5) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219682 Disease Relevance 0.61 Pain Relevance 0.46

In the present study we assessed the expression and localization of the sst receptor subtypes in lumbar dorsal root ganglia of normal rats and of rats with unilateral antigen-induced arthritis (AIA) in the knee joint.

Gene_expression (expression) of sst receptor in dorsal root ganglia associated with arthritis

6) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219682 Disease Relevance 0.35 Pain Relevance 0.35

To determine whether biosynthesis of somatostatin is enhanced in the primary sensory neurons by inflammatory pain, we examined the effects of adjuvant inoculation on the content of immunoreactive somatostatin, mainly composed of somatostatin-14 and somatostatin-28, in the dorsal root ganglia and the spinal cord of the rat.

Gene_expression (biosynthesis) of somatostatin in dorsal root ganglia associated with ipn, somatostatin and spinal cord

7) Confidence 0.78 Published 1990 Journal Neurosci. Res. Section Abstract Doc Link 1977111 Disease Relevance 0.24 Pain Relevance 0.57

Here we show that RVLM presympathetic neurons that express somatostatin 2A receptors are essential for maintaining and potentially generating sympathetic vasomotor tone.

Gene_expression (express) of somatostatin in RVLM associated with rostral ventrolateral medulla and somatostatin

8) Confidence 0.78 Published 2008 Journal Hypertension Section Abstract Doc Link 19001189 Disease Relevance 0 Pain Relevance 0.51

Somatostatin 2A receptor-expressing presympathetic neurons in the rostral ventrolateral medulla maintain blood pressure.

Gene_expression (expressing) of Somatostatin in medulla associated with rostral ventrolateral medulla and somatostatin

9) Confidence 0.78 Published 2008 Journal Hypertension Section Title Doc Link 19001189 Disease Relevance 0.11 Pain Relevance 0.54

Combined immunocytochemistry and in situ hybridization were used to map the expression of somatostatin receptors 1, 2A, 2B, 3, and 4 (sst1 through 4, respectively) in the rat RVLM. sst1 and sst2B were absent; sst3 and sst4 were sparse.

Gene_expression (expression) of sst1 in RVLM associated with rostral ventrolateral medulla and somatostatin

10) Confidence 0.78 Published 2008 Journal Hypertension Section Abstract Doc Link 19001189 Disease Relevance 0.13 Pain Relevance 0.63

Combined immunocytochemistry and in situ hybridization were used to map the expression of somatostatin receptors 1, 2A, 2B, 3, and 4 (sst1 through 4, respectively) in the rat RVLM. sst1 and sst2B were absent; sst3 and sst4 were sparse.

Gene_expression (expression) of somatostatin in RVLM associated with rostral ventrolateral medulla and somatostatin

11) Confidence 0.78 Published 2008 Journal Hypertension Section Abstract Doc Link 19001189 Disease Relevance 0.12 Pain Relevance 0.59

These results suggest that adrenal steroid hormones may reduce the synthesis of both substance P and somatostatin in the dorsal root ganglion cells.

Gene_expression (synthesis) of somatostatin in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, somatostatin and substance p

12) Confidence 0.77 Published 1994 Journal Brain Res. Section Abstract Doc Link 7516260 Disease Relevance 0.43 Pain Relevance 0.72

Most of the dorsal root ganglion (DRG) neurons containing either calcitonin gene-related peptide (CGRP), substance P (SP) or somatostatin (SST) coexpressed latexin.

Gene_expression (coexpressed) of somatostatin in neurons associated with ganglion cysts, dorsal root ganglion, somatostatin, substance p and calcitonin gene-related peptide

13) Confidence 0.76 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729242 Disease Relevance 0.36 Pain Relevance 0.55

Most of the dorsal root ganglion (DRG) neurons containing either calcitonin gene-related peptide (CGRP), substance P (SP) or somatostatin (SST) coexpressed latexin.

Gene_expression (coexpressed) of SST in neurons associated with ganglion cysts, dorsal root ganglion, somatostatin, substance p and calcitonin gene-related peptide

14) Confidence 0.76 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729242 Disease Relevance 0.36 Pain Relevance 0.55

These results indicate that one mechanism by which urethane induced low basal gastric acid secretion involved increased synthesis and release of endogenous somatostatin and associated inhibition of gastrin secretion.

Gene_expression (synthesis) of somatostatin associated with somatostatin

15) Confidence 0.76 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0 Pain Relevance 0.36

Somatostatin is synthesized and released by aspiny interneurons of the neostriatum.

Gene_expression (synthesized) of Somatostatin in interneurons associated with somatostatin

16) Confidence 0.75 Published 2002 Journal Neuroscience Section Abstract Doc Link 11823066 Disease Relevance 0 Pain Relevance 0.43

The lamina II neurons express somatostatin [The neuropeptide Y Y1 receptor is a somatic receptor on dorsal root ganglion neurons and a postsynaptic receptor on somatostatin dorsal horn neurons.

Gene_expression (express) of somatostatin in dorsal root ganglion associated with ganglion cysts, root ganglion neuron, neuropeptide, somatostatin and dorsal horn neuron

17) Confidence 0.75 Published 2006 Journal Neuroscience Section Abstract Doc Link 16448775 Disease Relevance 0.18 Pain Relevance 0.65

Astrocytes were prepared from rats of 4 ages, embryonic day 20, postnatal days 3 and 8, and adult, in order to study the developmental time course of expression of enkephalin and somatostatin (SS).

Gene_expression (expression) of somatostatin in Astrocytes associated with somatostatin and enkephalin

18) Confidence 0.75 Published 1992 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1355015 Disease Relevance 0 Pain Relevance 0.34

Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors.

Gene_expression (synthesis) of somatostatin associated with antagonist, mu opioid receptor and somatostatin

19) Confidence 0.75 Published 1988 Journal J. Med. Chem. Section Title Doc Link 2903246 Disease Relevance 0.22 Pain Relevance 0.40

Developmental expression of the proenkephalin and prosomatostatin genes in cultured cortical and cerebellar astrocytes.

Gene_expression (expression) of somatostatin in astrocytes associated with enkephalin

20) Confidence 0.75 Published 1992 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 1355015 Disease Relevance 0 Pain Relevance 0.60

General Comments

This test has worked.