INT73624

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.25
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
fat 1
colon 1
PPARG (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 85.96 High High
agonist 17 83.96 Quite High
antagonist 2 80.48 Quite High
COX-2 inhibitor 1 75.20 Quite High
COX2 2 25.00 Low Low
Inflammation 30 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 42 99.92 Very High Very High Very High
Obesity 155 98.68 Very High Very High Very High
Colon Cancer 63 96.28 Very High Very High Very High
Diabetes Mellitus 47 93.76 High High
Diabetic Retinopathy 3 93.28 High High
Disease 70 87.64 High High
INFLAMMATION 38 85.76 High High
Apoptosis 10 82.00 Quite High
Insulin Resistance 21 80.32 Quite High
Metabolic Syndrome 11 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific repressive chromatin marks and DNA methylation are associated with PPARG transcription
Transcription (transcription) of PPARG
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0 Pain Relevance 0.04
Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription.
Transcription (transcription) of Peroxisome proliferator-activated receptor gamma in fat
2) Confidence 0.67 Published 2000 Journal Br. J. Nutr. Section Title Doc Link 11242474 Disease Relevance 0.09 Pain Relevance 0.13
Other three variants in PPARG putative promoter have been identified: A-14G, C-681G, and C-689T [71], even though their impact on PPARG transcription and function has not been completely elucidated.
Transcription (transcription) of PPARG
3) Confidence 0.66 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.52 Pain Relevance 0
It has been hypothesized that this SNP might alter PPARG transcript abundance influencing in turn the expression levels of some PPAR?
Transcription (abundance) of PPARG
4) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.64 Pain Relevance 0
Another PPARG nucleotide variation, affecting PPAR?
Transcription (variation) of PPARG
5) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.53 Pain Relevance 0
PPARgamma messenger RNA (mRNA) and protein levels were assayed in colonic tumors and normal adjacent mucosa, as well as in a variety of human colon cancer cell lines.
Transcription (levels) of PPARgamma in colon associated with cancer and colon cancer
6) Confidence 0.52 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9472692 Disease Relevance 0.97 Pain Relevance 0.22
ET-18-O-CH3 treatment resulted in elevated release of 15d-PGJ2 and DNA binding and transcriptional activity of PPARgamma.
Transcription (activity) of PPARgamma
7) Confidence 0.51 Published 2005 Journal FEBS Lett. Section Abstract Doc Link 16253239 Disease Relevance 0.50 Pain Relevance 0.10

General Comments

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