INT73625

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 108
Total Number 151
Disease Relevance 104.85
Pain Relevance 21.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
colon 7
stroma 4
brains 3
skin 3
liver 2
PPARG (Homo sapiens)
PPARG - A12P (1) PPARG - F388L (1)
Pain Link Frequency Relevance Heat
COX2 2662 100.00 Very High Very High Very High
agonist 608 100.00 Very High Very High Very High
Dopamine 4 99.20 Very High Very High Very High
Inflammation 462 99.14 Very High Very High Very High
cytokine 72 99.12 Very High Very High Very High
cINOD 257 99.02 Very High Very High Very High
qutenza 33 97.92 Very High Very High Very High
Inflammatory response 59 96.84 Very High Very High Very High
Inflammatory mediators 5 96.08 Very High Very High Very High
antagonist 103 91.36 High High
Disease Link Frequency Relevance Heat
Cancer 3102 100.00 Very High Very High Very High
Repression 276 100.00 Very High Very High Very High
Natriuresis 2 100.00 Very High Very High Very High
Skin Cancer 2014 99.96 Very High Very High Very High
Nevus 512 99.96 Very High Very High Very High
Eczema 3 99.88 Very High Very High Very High
Colon Cancer 2726 99.86 Very High Very High Very High
Obesity 1122 99.84 Very High Very High Very High
Coronary Artery Disease 185 99.80 Very High Very High Very High
Colorectal Cancer 41 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human colorectal cancer cell lines SW480 and HCT116 both expressed functional PPARgamma.
Gene_expression (expressed) of PPARgamma in SW480 associated with colon cancer
1) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12606626 Disease Relevance 0.75 Pain Relevance 0.15
In conclusion, we demonstrate that epigenetic events play a role in PPARG expression.
Gene_expression (expression) of PPARG
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.35 Pain Relevance 0.13
All together these data demonstrate that extensive promoter methylation is associated with reduced PPARG expression in CRC cell lines.


Gene_expression (expression) of PPARG associated with colon cancer
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.25 Pain Relevance 0
The molecular mechanisms underlying PPARG expression regulation in CRC progression are still unknown [9].
Gene_expression (expression) of PPARG associated with colon cancer
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.49 Pain Relevance 0.04
Dissecting the PPARG proximal promoter, we demonstrate that a specific DNA segment (M3) is differentially methylated and PPARG expression is directly correlated with its methylation status (Figs. 1 and 2).
Gene_expression (expression) of PPARG in proximal
5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 1.08 Pain Relevance 0
Thus, to determine whether PPARG reduced expression is correlated with DNA methylation, we examined the entire promoter region.
Spec (whether) Gene_expression (expression) of PPARG
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.64 Pain Relevance 0
These findings suggest that promoter methylation could play a role in silencing PPARG expression in the CRC cell lines analyzed.


Gene_expression (expression) of PPARG associated with colon cancer
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.31 Pain Relevance 0
siRNA mediated knock-down of MeCP2 and EZH2 rescues PPARG expression in HCT116 colon cancer cells
Gene_expression (expression) of PPARG in colon associated with targeted disruption and colon cancer
8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.35 Pain Relevance 0
In this report, we analyzed one-hundred and fifty-two primary CRCs and paired normal mucosa in order to correlate PPARG expression variations mediated by epigenetic events with tumor progression and patients' survival.
Gene_expression (expression) of PPARG associated with cancer and colon cancer
9) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.64 Pain Relevance 0
To provide insights into the mechanism(s) by which DNA methylation and histone modifications affect PPARG expression, quantitative ChIP assays were performed investigating the promoter segment extending from ?
Gene_expression (expression) of PPARG
10) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0 Pain Relevance 0.04
Consistently, MeCP2 and EZH2 levels inversely correlate with PPARG expression in the CRC cells investigated.
Gene_expression (expression) of PPARG associated with colon cancer
11) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.64 Pain Relevance 0
Consistently, LINE methylation levels, a surrogate marker of global DNA methylation, does not correlate with PPARG expression in CRC [10].
Gene_expression (expression) of PPARG associated with colon cancer
12) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.93 Pain Relevance 0
We also demonstrate that a reduced PPARG expression due to specific promoter methylation is associated with advanced tumour stages (Duke's stages C–D), deep invasion, and, ultimately, shorter survival.
Gene_expression (expression) of PPARG associated with cancer
13) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.96 Pain Relevance 0
To investigate whether these HCT116 growth characteristics rely on PPARG expression, we stably silenced PPARG in HT29 cells.
Gene_expression (expression) of PPARG
14) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.63 Pain Relevance 0
Consistently, variations in PPARG expression or gene mutations have been associated with tumorigenesis [4]–[6].
Gene_expression (expression) of PPARG
15) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.47 Pain Relevance 0.05
PPARG expression was assessed in CRC tissues and paired normal mucosa by western blot and immunohistochemistry and related to patients' clinicopathological parameters and survival.
Gene_expression (expression) of PPARG associated with colon cancer
16) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997072 Disease Relevance 0.54 Pain Relevance 0
Accordingly, silencing MeCP2 caused a marked increase of PPARG expression (Figure 4, panel D).
Gene_expression (expression) of PPARG
17) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.31 Pain Relevance 0
PPARG expression was synergistically induced by the combined treatment with AZA and TSA in HCT116 cells while was not affected in HT29 cells, when the drugs were used either alone or in combination (Figure S3).
Gene_expression (expression) of PPARG
18) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.23 Pain Relevance 0
123 to +49) were always methylated or unmethylated in normal and tumor samples and were not correlated with PPARG expression levels (Figure 1, panel E).
Gene_expression (expression) of PPARG associated with cancer
19) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.53 Pain Relevance 0
(PPARG) expression and epigenetic changes occurring in colorectal-cancer pathogenesis is largely unknown.
Gene_expression (expression) of PPARG associated with cancer
20) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997072 Disease Relevance 0.49 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox