INT73626

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 31
Disease Relevance 18.82
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
colon 4
Adipocyte 4
proximal 2
RKO 2
microglial cells 2
PPARG (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 162 100.00 Very High Very High Very High
agonist 68 99.90 Very High Very High Very High
cINOD 55 99.34 Very High Very High Very High
Dopamine 2 99.20 Very High Very High Very High
Inflammation 19 99.14 Very High Very High Very High
Inflammatory response 12 95.44 Very High Very High Very High
cytokine 11 92.84 High High
antagonist 22 91.36 High High
aspirin 5 88.52 High High
Bile 81 80.32 Quite High
Disease Link Frequency Relevance Heat
Nevus 31 99.96 Very High Very High Very High
Cancer 425 99.84 Very High Very High Very High
Disease 57 99.80 Very High Very High Very High
Colon Cancer 552 99.56 Very High Very High Very High
Melanoma 28 99.52 Very High Very High Very High
Targeted Disruption 12 99.52 Very High Very High Very High
Apoptosis 65 99.28 Very High Very High Very High
INFLAMMATION 59 99.14 Very High Very High Very High
Colorectal Cancer 6 98.68 Very High Very High Very High
Skin Cancer 122 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPARG expression was synergistically induced by the combined treatment with AZA and TSA in HCT116 cells while was not affected in HT29 cells, when the drugs were used either alone or in combination (Figure S3).
Positive_regulation (induced) of Gene_expression (expression) of PPARG
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.23 Pain Relevance 0
In the tissues, the expression of PPARgamma was elevated in tumors relative to the adjacent normal tissues.
Positive_regulation (elevated) of Gene_expression (expression) of PPARgamma associated with cancer
2) Confidence 0.70 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12711249 Disease Relevance 0.55 Pain Relevance 0.07
The PPARG gene contains 9 exons, spans more than 100 kilobases, and, because of alternative mRNA splicing, results in the production of 2 protein isoforms, PPARG1 and PPARG2 (5).
Positive_regulation (results) of Gene_expression (production) of PPARG2
3) Confidence 0.70 Published 2010 Journal American Journal of Epidemiology Section Body Doc Link PMC2834889 Disease Relevance 0.37 Pain Relevance 0.04
We suggest that upregulation of PPARgamma expression and activation may be, at least partially, responsible for sulindac's antiproliferative effect.
Positive_regulation (upregulation) of Gene_expression (expression) of PPARgamma
4) Confidence 0.69 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11948457 Disease Relevance 0.58 Pain Relevance 0.17
Thus, we have shown that PPARgamma gene and protein expression is elevated in rodent colon tumors, in selected human colon cancer cell lines and that the PPARgamma receptor is functional in CaCo-2 cells.
Positive_regulation (elevated) of Gene_expression (expression) of PPARgamma in colon associated with colon cancer
5) Confidence 0.67 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9472692 Disease Relevance 0.91 Pain Relevance 0
Accordingly, compared to benign nevi, expression of both COX2 and PPARG was significantly increased in primary melanomas (P = .02 and P = .001).
Positive_regulation (increased) of Gene_expression (expression) of PPARG associated with melanoma, nevus and cox2
6) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 2.19 Pain Relevance 0.32
By examining four additional CRC cell lines, we found that also RKO cells were negative for PPARG expression, due to aberrantly methylated M3 region (Table S2 and data not shown).
Positive_regulation (negative) of Gene_expression (expression) of PPARG in RKO associated with colon cancer
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.33 Pain Relevance 0
siRNA mediated knock-down of MeCP2 and EZH2 rescues PPARG expression in HCT116 colon cancer cells
Positive_regulation (rescues) of Gene_expression (expression) of PPARG in colon associated with targeted disruption and colon cancer
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.35 Pain Relevance 0
In conclusion, we demonstrate that epigenetic events play a role in PPARG expression.
Positive_regulation (role) of Gene_expression (expression) of PPARG
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.35 Pain Relevance 0.13
To investigate whether these HCT116 growth characteristics rely on PPARG expression, we stably silenced PPARG in HT29 cells.
Positive_regulation (silenced) of Gene_expression (silenced) of PPARG
10) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.62 Pain Relevance 0
Accordingly, silencing MeCP2 caused a marked increase of PPARG expression (Figure 4, panel D).
Positive_regulation (increase) of Gene_expression (expression) of PPARG
11) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.31 Pain Relevance 0
Dissecting the PPARG proximal promoter, we demonstrate that a specific DNA segment (M3) is differentially methylated and PPARG expression is directly correlated with its methylation status (Figs. 1 and 2).
Positive_regulation (correlated) of Gene_expression (expression) of PPARG in proximal
12) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 1.08 Pain Relevance 0
The PPARG gene contains 9 exons, spans more than 100 kilobases, and, because of alternative mRNA splicing, results in the production of 2 protein isoforms, PPARG1 and PPARG2 (5).
Positive_regulation (results) of Gene_expression (production) of PPARG1
13) Confidence 0.50 Published 2010 Journal American Journal of Epidemiology Section Body Doc Link PMC2834889 Disease Relevance 0.37 Pain Relevance 0.04
Upregulation of PPARG expression is induced during mitotic arrest very early in adipose differentiation and stimulates the adipogenic pathway, activating the transcription of other adipose-specific genes [32]–[34].
Positive_regulation (Upregulation) of Gene_expression (expression) of PPARG
14) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0.04
We suggest that upregulation of PPARgamma expression and activation may be, at least partially, responsible for sulindac's antiproliferative effect.
Positive_regulation (activation) of Gene_expression (expression) of PPARgamma
15) Confidence 0.50 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11948457 Disease Relevance 0.57 Pain Relevance 0.17
There was a marked increase in PPARgamma RNA levels in four out of four of the colonic tumors compared to paired normal mucosa, where little expression of PPARgamma was detected.
Positive_regulation (increase) of Gene_expression (levels) of PPARgamma associated with cancer
16) Confidence 0.49 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9472692 Disease Relevance 1.09 Pain Relevance 0.20
Accordingly, tumor-associated inflammatory and angiogenic processes mediated by COX2 overexpression or PPARG deficiency were suggested to play a pivotal role in the biology of melanoma progression [22].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPARG associated with inflammation, cancer, cox2 and skin cancer
17) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 1.01 Pain Relevance 0.35
PPARG expression is re-activated by pharmacologic demethylation
Positive_regulation (activated) of Gene_expression (expression) of PPARG
18) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.30 Pain Relevance 0
To verify whether PPARG expression can be re-activated by pharmacologic demethylation, we treated HCT116 cells with AZA, a well-known inhibitor of DNA methylation.
Positive_regulation (activated) of Gene_expression (expression) of PPARG
19) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.29 Pain Relevance 0
In this report, we analyzed one-hundred and fifty-two primary CRCs and paired normal mucosa in order to correlate PPARG expression variations mediated by epigenetic events with tumor progression and patients' survival.
Positive_regulation (mediated) of Gene_expression (expression) of PPARG associated with cancer and colon cancer
20) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.64 Pain Relevance 0

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