INT73627

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 11.14
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Fap) extracellular space (Fap) plasma membrane (Fap)
Anatomy Link Frequency
brain 1
central nervous system 1
Fap (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 19 99.62 Very High Very High Very High
Inflammation 12 99.38 Very High Very High Very High
Central nervous system 16 97.28 Very High Very High Very High
Spinal cord 3 78.92 Quite High
imagery 21 5.00 Very Low Very Low Very Low
Bile 16 5.00 Very Low Very Low Very Low
abdominal pain 12 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
COX-2 inhibitor 8 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 1114 100.00 Very High Very High Very High
Adenoma 257 100.00 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 21 100.00 Very High Very High Very High
Syndrome 92 99.98 Very High Very High Very High
Spontaneous Abortion 20 99.86 Very High Very High Very High
INFLAMMATION 18 99.38 Very High Very High Very High
Intestinal Cancer 9 99.20 Very High Very High Very High
Mucinous Adenocarcinoma 4 99.20 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 18 98.88 Very High Very High Very High
Liver Cancer 16 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac, a non-steroidal anti-inflammatory drug (NSAID), is effective in treating intestinal adenomas in humans with Familial Adenomatous Polyposis (FAP) and in preventing intestinal tumors in the C57Bl/6J-Min+ (Min) mouse, an animal model of FAP.
FAP Binding (treating) of associated with adenoma, inflammation, familial adenomatous polyposis, cinod and intestinal cancer
1) Confidence 0.36 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9472698 Disease Relevance 1.05 Pain Relevance 0.23
Other extra-colonic malignancies that are associated with FAP include pancreatic mucinous adenocarcinomas, liver (hepatoblastoma), and brain tumors.
FAP Binding (associated) of in brain associated with liver cancer, familial adenomatous polyposis, mucinous adenocarcinoma and brain tumor
2) Confidence 0.29 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.99 Pain Relevance 0.04
Multiple lymphoid aggregates can masquerade as early FAP, especially in children and young adults.
FAP Binding (masquerade) of associated with familial adenomatous polyposis
3) Confidence 0.23 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.89 Pain Relevance 0
Tests for FAP: why the different methods, why the testing is complex and not always complete and why it can be expensive?
FAP Binding (Tests) of associated with familial adenomatous polyposis
4) Confidence 0.23 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.76 Pain Relevance 0
In spite of the positive and exciting results obtained with this drug, doxycycline is not able to decrease all the FAP markers, and therefore we inferred that it would not perform optimally as a therapy for FAP.
FAP Binding (therapy) of associated with familial amyloidotic polyneuropathy
5) Confidence 0.20 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.46 Pain Relevance 0
The question that arises is how acceptable is prenatal diagnosis and pregnancy termination among FAP kindred?
FAP Binding (kindred) of associated with familial adenomatous polyposis and spontaneous abortion
6) Confidence 0.20 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.68 Pain Relevance 0
Turcot's syndrome associated with FAP appears to be somewhat specific with respect to the development of central nervous system tumors.
FAP Binding (associated) of in central nervous system associated with syndrome, familial adenomatous polyposis and central nervous system
7) Confidence 0.18 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 2.42 Pain Relevance 0.13
In addition to colonic symptoms, there occur other extra-colonic manifestations, which appear to be associated with FAP as shown in Table 2.
FAP Binding (associated) of associated with familial adenomatous polyposis
8) Confidence 0.18 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.88 Pain Relevance 0

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