INT73641

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2010
Negated 9
Speculated 5
Reported most in Abstract
Documents 45
Total Number 50
Disease Relevance 26.20
Pain Relevance 12.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 4
hypothalamus 3
body 3
pancreas 2
efferent neurons 1
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 97 100.00 Very High Very High Very High
Cholecystokinin 82 100.00 Very High Very High Very High
Intracerebroventricular 31 100.00 Very High Very High Very High
cytokine 30 100.00 Very High Very High Very High
Serotonin 16 100.00 Very High Very High Very High
dexamethasone 3 99.70 Very High Very High Very High
Inflammation 121 99.56 Very High Very High Very High
qutenza 36 99.48 Very High Very High Very High
agonist 59 99.00 Very High Very High Very High
Opioid 9 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 291 100.00 Very High Very High Very High
Pancreatitis 44 100.00 Very High Very High Very High
Appetite Loss 238 99.84 Very High Very High Very High
Colitis 18 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 8 99.84 Very High Very High Very High
INFLAMMATION 125 99.56 Very High Very High Very High
Aids-related Complex 9 99.52 Very High Very High Very High
Eating Disorder 19 99.40 Very High Very High Very High
Obesity 550 99.20 Very High Very High Very High
Insulin Resistance 65 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore investigated the effects of the serotonergic drug fluoxetine, which inhibits serotonin reuptake, on food intake and plasma leptin levels in lean and obese Zucker rats.
Spec (investigated) Regulation (effects) of leptin in plasma associated with obesity, serotonin and fluoxetine
1) Confidence 0.62 Published 1999 Journal Horm. Metab. Res. Section Abstract Doc Link 10437624 Disease Relevance 0.36 Pain Relevance 0.60
In another report probiotic capsules containing L. acidophilus and Bifidobacterium longum had no effect on plasma leptin in a group of men even after 2 months of oral intake [14].
Neg (no) Regulation (effect) of leptin in capsules
2) Confidence 0.62 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.49 Pain Relevance 0.11
Despite reductions in circulating leptin levels in response to LPS during the neonatal period, no long-term effects on leptin were seen.
Neg (no) Regulation (effects) of leptin
3) Confidence 0.61 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17507437 Disease Relevance 0.99 Pain Relevance 0.11
The aim of this study was to evaluate the effect of intracerebroventricular (i.c.v.) administration of LPS on CIP and plasma leptin level and to investigate the involvement of sensory nerves (SN) in the effects of LPS on CIP.
Regulation (effect) of leptin in sensory nerves associated with pancreatitis and intracerebroventricular
4) Confidence 0.58 Published 2002 Journal Med. Sci. Monit. Section Abstract Doc Link 11951059 Disease Relevance 0.75 Pain Relevance 0.09
Obese rodents have elevated leptin levels but blunted leptin sensitivity.
Regulation (sensitivity) of leptin associated with obesity
5) Confidence 0.54 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2867220 Disease Relevance 0.61 Pain Relevance 0
Among its actions presumed to be mediated through such mechanisms are the effects on appetite, body weight and plasma leptin levels [17,35].
Regulation (effects) of leptin in plasma associated with body weight
6) Confidence 0.51 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.90 Pain Relevance 0.28
Despite reductions in circulating leptin levels in response to LPS during the neonatal period, no long-term effects on leptin were seen.
Regulation (circulating) of leptin
7) Confidence 0.45 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17507437 Disease Relevance 1.02 Pain Relevance 0.11
The peripheral effect of leptin on gastric motility appears to be mediated by CCK(1) receptors, suggesting the release of CCK and the involvement of vagal afferent fibers.
Regulation (effect) of leptin
8) Confidence 0.45 Published 2007 Journal Physiol Res Section Abstract Doc Link 16792473 Disease Relevance 0.22 Pain Relevance 0.05
The magnitude of membrane depolarization was dependent on leptin concentration and occurred in both capsaicin-sensitive and capsaicin-insensitive neurons.
Regulation (dependent) of leptin in neurons associated with qutenza
9) Confidence 0.45 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16192299 Disease Relevance 0 Pain Relevance 0.45
Role of ghrelin and leptin in predicting the severity of acute pancreatitis.
Regulation (Role) of leptin associated with pancreatitis
10) Confidence 0.45 Published 2007 Journal Dig. Dis. Sci. Section Title Doc Link 17333355 Disease Relevance 0.65 Pain Relevance 0.14
Ghrelin and leptin are the hormones that influence endocrine and exocrine functions of the pancreas and regulate feeding behaviors and energy metabolism.
Regulation (regulate) of leptin in pancreas
11) Confidence 0.45 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17333355 Disease Relevance 0.40 Pain Relevance 0.04
As leptin and adiponectin could be possible factors in the serotonergic regulation of bone metabolism, we also determined the levels of these factors in plasma samples of all animals.
Spec (possible) Regulation (regulation) of leptin in plasma
12) Confidence 0.44 Published 2007 Journal J. Cell. Biochem. Section Abstract Doc Link 17163489 Disease Relevance 0.09 Pain Relevance 0.43
On the other hand, perivagal capsaicin prevented the protective effects of both CCK-8s and leptin on colitis.
Regulation (effects) of leptin associated with colitis, qutenza and cholecystokinin
13) Confidence 0.44 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 14599722 Disease Relevance 0.89 Pain Relevance 1.14
Leptin and adiponectin levels were not different between the control group and fluoxetine-treated group, indicating that these factors were not involved in the observed changes in bone geometry and quality.
Neg (not) Regulation (different) of Leptin associated with fluoxetine
14) Confidence 0.44 Published 2007 Journal J. Cell. Biochem. Section Abstract Doc Link 17163489 Disease Relevance 0.08 Pain Relevance 0.42
The present study was designed to investigate the putative protective effects of CCK and leptin on acute colonic inflammation.
Spec (investigate) Regulation (effects) of leptin associated with inflammation and cholecystokinin
15) Confidence 0.44 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 14599722 Disease Relevance 0.34 Pain Relevance 0.67
Leptin or CCK-8s treatment reduced these parameters in a similar manner, while co-administration of leptin and CCK was found to be more effective in reducing the macroscopic score and WWI.
Regulation (effective) of leptin associated with cholecystokinin
16) Confidence 0.44 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 14599722 Disease Relevance 0.87 Pain Relevance 1.19
Thus, it may be important to consider the daily patterns of gene expression and availability of hypothalamic orexigenic peptides in investigations aimed at elucidating the central mechanisms underlying the feedback action of the normal and altered leptin secretion patterns.
Regulation (altered) of leptin
17) Confidence 0.44 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.36 Pain Relevance 0.04
The aim of present study was to evaluate the influence of surgical fundectomy and exogenous leptin on the secretion of pancreatic juice in anesthetized rats.
Regulation (influence) of leptin
18) Confidence 0.44 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15608362 Disease Relevance 0.07 Pain Relevance 0.08
This study was designed to compare the effects of leptin and cholecystokinin-8 (CCK-8) on gastric mucosal lesions induced by topical application of 75% ethanol or acidified aspirin.
Regulation (effects) of leptin associated with aspirin and cholecystokinin
19) Confidence 0.44 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10422768 Disease Relevance 0.09 Pain Relevance 0.37
von Wilmsdorff et al. investigated the of typical and atypical antipsychotic drugs on leptin concentration in blood and changes in the receptor expression in the hypothalamus of male Wistar rats. and conclude that during the treatment period, the tested drugs did not act directly on the leptin regulatory system.
Neg (not) Regulation (act) of leptin in hypothalamus
20) Confidence 0.44 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2954730 Disease Relevance 0.43 Pain Relevance 0.07

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