INT73642

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 5.57
Pain Relevance 6.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ctse) peptidase activity (Ctse)
Anatomy Link Frequency
CEA 5
NAcc 1
PVN 1
Ctse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 294 100.00 Very High Very High Very High
Dopamine 144 100.00 Very High Very High Very High
amygdala 143 100.00 Very High Very High Very High
Nucleus accumbens 9 99.80 Very High Very High Very High
Nicotine 16 99.70 Very High Very High Very High
Anterior cingulate cortex 78 99.08 Very High Very High Very High
gABA 24 96.92 Very High Very High Very High
acular 8 96.36 Very High Very High Very High
antagonist 37 95.92 Very High Very High Very High
Dynorphin 8 94.44 High High
Disease Link Frequency Relevance Heat
Disease 19 99.92 Very High Very High Very High
Anxiety Disorder 297 99.72 Very High Very High Very High
Cancer 42 99.60 Very High Very High Very High
Appetite Loss 4 99.58 Very High Very High Very High
Colon Cancer 87 99.56 Very High Very High Very High
Recurrence 45 99.28 Very High Very High Very High
Hyperplasia 7 97.68 Very High Very High Very High
Eating Disorder 6 96.44 Very High Very High Very High
Stress 27 96.12 Very High Very High Very High
Aids-related Complex 2 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Tooth movement promotes Fos-IR in the CEA and LH according to the magnitude of the force applied.


Positive_regulation (promotes) of CEA in CEA
1) Confidence 0.44 Published 2010 Journal Angle Orthod Section Body Doc Link 19852649 Disease Relevance 0 Pain Relevance 0
Twenty-nine male Sprague-Dawley rats underwent CEA and were divided into 3 treatment groups as follows: (1) control (placebo), (2) 7.5 mg/kg Toradol, and (3) 10 mg/kg Toradol.
Positive_regulation (underwent) of CEA associated with acular
2) Confidence 0.38 Published 2007 Journal Vasc Endovascular Surg Section Abstract Doc Link 17942855 Disease Relevance 1.13 Pain Relevance 0.64
RESULTS: The results show that in the control group, the intramuscular injection of a ketamine/ xylazine mixture did not induce Fos-IR cells in the CEA or in the LH.
Neg (not) Positive_regulation (induce) of CEA in CEA
3) Confidence 0.38 Published 2010 Journal Angle Orthod Section Body Doc Link 19852649 Disease Relevance 0 Pain Relevance 0
Film autoradiographic studies showed that nicotine significantly increased c-fos mRNA expression in both PVN and CEA.
Positive_regulation (increased) of CEA in PVN associated with nicotine and amygdala
4) Confidence 0.38 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16739166 Disease Relevance 0.15 Pain Relevance 0.96
Dopamine content was increased by ketamine administration in the CEA and the Nacc.
Positive_regulation (increased) of CEA associated with dopamine and ketamine
5) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.64 Pain Relevance 0.76
The dopamine metabolic ratios in our study (Table 2) indicate that the increase in dopamine content in the CEA after ketamine administration is due to a decrease in turnover (indicative of decreased release and a subsequent increase in storage of the neurotransmitter in axon terminals).
Positive_regulation (increase) of CEA associated with neurotransmitter, dopamine and ketamine
6) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.27 Pain Relevance 0.89
In terms of cFos expression, fear conditioning elevates expression in the BLA, but not the CEA.
Neg (not) Positive_regulation (elevates) of CEA associated with anxiety disorder
7) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.40 Pain Relevance 0.74
Our results show an increase in the PDYN mRNA level in the CEA and NAcc shell and no changes of PENK gene expression after heroin self-administration.
Positive_regulation (increase) of CEA in NAcc associated with nucleus accumbens and amygdala
8) Confidence 0.26 Published 2009 Journal Brain Res. Section Abstract Doc Link 19100723 Disease Relevance 0 Pain Relevance 0.52
Interestingly, work in other laboratories indicates that anorectic agents consistently increase FLI in BNST and CEA.
Positive_regulation (increase) of CEA in CEA associated with appetite loss and amygdala
9) Confidence 0.25 Published 1998 Journal Brain Res. Section Abstract Doc Link 9473572 Disease Relevance 0.63 Pain Relevance 0.58
Elevated levels of CEA are shown by repeated measurements.
Positive_regulation (levels) of CEA
10) Confidence 0.14 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2474836 Disease Relevance 0.88 Pain Relevance 0.09
Film autoradiographic studies showed that nicotine significantly increased c-fos mRNA expression in both PVN and CEA.
Positive_regulation (increased) of CEA in CEA associated with nicotine and amygdala
11) Confidence 0.13 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16739166 Disease Relevance 0.15 Pain Relevance 0.96
All patients with elevated CEA prior to surgery are requested to undergo this test at every postoperative clinical examination.
Positive_regulation (elevated) of CEA
12) Confidence 0.12 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2474836 Disease Relevance 0.51 Pain Relevance 0.05
Increase in CEA measurements shown by repeated measurements.
Positive_regulation (Increase) of CEA
13) Confidence 0.12 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2474836 Disease Relevance 0.83 Pain Relevance 0.09
Our results show an increase in the PDYN mRNA level in the CEA and NAcc shell and no changes of PENK gene expression after heroin self-administration.
Positive_regulation (increase) of CEA in CEA associated with nucleus accumbens and amygdala
14) Confidence 0.09 Published 2009 Journal Brain Res. Section Abstract Doc Link 19100723 Disease Relevance 0 Pain Relevance 0.52

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