INT73649

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Context Info
Confidence 0.80
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 28
Total Number 32
Disease Relevance 11.01
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
spinal cord 2
sciatic nerves 2
neurons 2
dorsal root ganglia 2
lower limb 1
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 275 99.76 Very High Very High Very High
Spinal cord 87 99.24 Very High Very High Very High
cytokine 186 99.02 Very High Very High Very High
Sciatic nerve 66 98.44 Very High Very High Very High
Inflammatory response 15 97.66 Very High Very High Very High
dexamethasone 8 97.48 Very High Very High Very High
Eae 6 97.32 Very High Very High Very High
Neuritis 16 96.12 Very High Very High Very High
Thermal hyperalgesia 4 94.88 High High
metalloproteinase 40 93.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 320 99.76 Very High Very High Very High
Injury 87 99.58 Very High Very High Very High
Sepsis 189 99.36 Very High Very High Very High
Diabetes Mellitus 8 99.10 Very High Very High Very High
Apoptosis 24 98.02 Very High Very High Very High
Experimental Autoimmune Neuritis 16 97.08 Very High Very High Very High
Stress 60 97.04 Very High Very High Very High
Hyperalgesia 13 94.88 High High
Cancer 28 94.00 High High
Obesity 64 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylation of c-Jun NH (2)-terminal protein kinase (JNK), one of the mitogen-activated protein kinases, was analyzed in the sciatic nerves of Lewis rats with experimental autoimmune neuritis (EAN).
Spec (analyzed) Phosphorylation (phosphorylation) of Jun in sciatic nerves associated with experimental autoimmune neuritis, sciatic nerve and neuritis
1) Confidence 0.80 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.63 Pain Relevance 0.56
Increased phosphorylation of c-Jun NH (2)-terminal protein kinase in the sciatic nerves of Lewis rats with experimental autoimmune neuritis.
Phosphorylation (phosphorylation) of Jun in sciatic nerves associated with experimental autoimmune neuritis, sciatic nerve and neuritis
2) Confidence 0.80 Published 2006 Journal J. Vet. Sci. Section Title Doc Link 16434843 Disease Relevance 0.97 Pain Relevance 0.80
In addition, c-jun AS-ODN also suppressed the remarkable elevations of VIP and NPY mRNAs and the percentages of phosphorylated c-Jun-, VIP-, and NPY-immunoreactive neurons observed in DRGs following CCI.
Phosphorylation (phosphorylated) of c-Jun in DRGs associated with eae
3) Confidence 0.66 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17081520 Disease Relevance 1.03 Pain Relevance 0.97
CONCLUSIONS/INTERPRETATION: Fidarestat-sensitive phosphorylation of JNK and c-Jun occurs in fast-conduction mechanoceptors-the same class of neurones that registers the changes in sensory nerve conduction velocity-and in nociceptors.
Phosphorylation (phosphorylation) of c-Jun in nociceptors
4) Confidence 0.44 Published 2006 Journal Diabetologia Section Body Doc Link 16456679 Disease Relevance 0 Pain Relevance 0
AIMS/HYPOTHESIS: This study was designed to determine whether diabetes in rats is associated with phosphorylation of c-Jun N-terminal kinase (JNK) and one of its transcription factors, c-Jun, in sensory neurones innervating the lower limb.
Phosphorylation (phosphorylation) of c-Jun in lower limb associated with diabetes mellitus
5) Confidence 0.44 Published 2006 Journal Diabetologia Section Abstract Doc Link 16456679 Disease Relevance 0.25 Pain Relevance 0.07
Phosphorylation of JNK and c-Jun in lumbar dorsal root ganglia was determined by binding of phospho-specific antibodies using western blots and immunocytochemistry.
Spec (determined) Phosphorylation (Phosphorylation) of c-Jun in dorsal root ganglia
6) Confidence 0.44 Published 2006 Journal Diabetologia Section Body Doc Link 16456679 Disease Relevance 0 Pain Relevance 0
We also sought to determine which neuronal phenotypes are affected and to examine the effect of aldose reductase inhibition on JNK and c-Jun phosphorylation.
Phosphorylation (phosphorylation) of c-Jun in neuronal
7) Confidence 0.44 Published 2006 Journal Diabetologia Section Abstract Doc Link 16456679 Disease Relevance 0.24 Pain Relevance 0.07
Gel supershift studies showed that spinal cord extracts contained CREB, P-CREB, and phosphorylated c-Jun (P-c-Jun) proteins that bound to the DYNCRE3 site.
Phosphorylation (phosphorylated) of c-Jun in spinal cord associated with spinal cord
8) Confidence 0.42 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9473689 Disease Relevance 0.50 Pain Relevance 0.30
The sciatic nerve and the lumbar tract of the spinal cord were processed to evaluate the levels of the phosphorylated form of PKCgamma, ERK 1,2, SAP/JNK, p-38 and c-Jun; furthermore, the mRNA expression of the early genes c-Jun and c-Fos has been investigated.
Phosphorylation (phosphorylated) of c-Jun in spinal cord associated with sciatic nerve and spinal cord
9) Confidence 0.41 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.57 Pain Relevance 0.57
Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families.
Phosphorylation (phosphorylation) of AP-1 associated with dexamethasone
10) Confidence 0.36 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.05
Thus, in our case statistically insignificant reduction of p-JNK concentration in cells could result in significant down-regulation of Jun phosphorylation.
Phosphorylation (phosphorylation) of Jun
11) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.09
This comes as a surprise, as it is presumed that Jun can be phosphorylated only by the action of JNK.
Phosphorylation (phosphorylated) of Jun
12) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.07
In addition, AP-1 expression or CREB phosphorylation appears not to be involved the potentiative action of DEX on proENK mRNA expression in CTX- and PTX-treated astrocytes.
Phosphorylation (phosphorylation) of AP-1 in astrocytes
13) Confidence 0.32 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295234 Disease Relevance 0.15 Pain Relevance 0
In addition, phosphorylation of CREB rather than the increase of AP-1 may have a possible role at least early stage in PGE2-induced proENK mRNA level and CHX-evoked potentiation.
Phosphorylation (phosphorylation) of AP-1 in PGE2
14) Confidence 0.31 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9757037 Disease Relevance 0 Pain Relevance 0.03
In addition, C2 ceramide also increased AP-1 proteins, such as Fra-1, c-Jun, JunB and JunD, and phosphorylation of CREB.
Phosphorylation (phosphorylation) of AP-1
15) Confidence 0.30 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0
B (p65) (1:1,000), phosphorylated NF-IL-6 (1:1,500), or phosphorylated AP-1 (c-Jun) (1:500).
Phosphorylation (phosphorylated) of c-Jun
16) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0
B (p65) (1:1,000), phosphorylated NF-IL-6 (1:1,500), or phosphorylated AP-1 (c-Jun) (1:500).
Phosphorylation (phosphorylated) of AP-1
17) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0
B (p65) (1:1,000), phosphorylated NF-IL-6 (1:1,500), or phosphorylated AP-1 (c-Jun) (1:500).
Phosphorylation (phosphorylated) of AP-1
18) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0
B (p65) (1:1,000), phosphorylated NF-IL-6 (1:1,500), or phosphorylated AP-1 (c-Jun) (1:500).
Phosphorylation (phosphorylated) of c-Jun
19) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0
However, levels of phosphorylated Jun were markedly decreased in the presence of MP (Fig 5B), thus implying importance of transcription factor AP-1 (consisted of p-Jun and Fos) for the observed inhibitory effect of MP.


Phosphorylation (phosphorylated) of Jun
20) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.03

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