INT7365

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 2.83
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
liver 1
fat 1
somatotropes 1
immune system 1
hindlimb 1
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 13 99.56 Very High Very High Very High
opioid receptor 4 99.48 Very High Very High Very High
Opioid 17 99.08 Very High Very High Very High
withdrawal 2 99.04 Very High Very High Very High
Serotonin 5 98.28 Very High Very High Very High
Clonidine 14 98.26 Very High Very High Very High
agonist 36 97.88 Very High Very High Very High
cytokine 170 95.28 Very High Very High Very High
Enkephalin 7 89.88 High High
Potency 2 88.36 High High
Disease Link Frequency Relevance Heat
Stress 98 99.72 Very High Very High Very High
Disease 60 99.60 Very High Very High Very High
Acromegaly 52 98.76 Very High Very High Very High
Sepsis 76 97.52 Very High Very High Very High
Critical Illness 18 95.88 Very High Very High Very High
Targeted Disruption 6 89.48 High High
Frailty 5 81.20 Quite High
Diabetes Mellitus 6 79.60 Quite High
Body Weight 38 76.40 Quite High
Obesity 10 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the mechanism of GH deficiency associated with the disease, the effect of pituitary stalk section on GH secretion was studied in rats.
GH Binding (associated) of in pituitary stalk associated with disease
1) Confidence 0.37 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1676866 Disease Relevance 0.18 Pain Relevance 0
In two-day-old pups, clonidine had no effect on basal GH levels but, like yohimbine, prevented the increase in serum GH normally associated with nursing.
GH Binding (associated) of associated with clonidine
2) Confidence 0.36 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.51
In a previous study, we identified a number of negative interactions between the growth hormone (GH)-releasing effects of opioid, alpha 2 and serotonin agonists when given intravenously together to male rats.
GH Neg (negative) Binding (interactions) of associated with agonist, serotonin and opioid
3) Confidence 0.33 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8105398 Disease Relevance 0 Pain Relevance 1.02
In its initial encounter with growth hormone (GH) in vitro, epididymal fat excised from GH-deficient rats responds with an insulin-like increase in glucose metabolism.
GH Binding (encounter) of in fat
4) Confidence 0.30 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3033537 Disease Relevance 0.22 Pain Relevance 0.15
This result suggests that GHRH is not involved in the GH rebound following somatostatin withdrawal in food-deprived rats.
GH Binding (rebound) of associated with somatostatin and withdrawal
5) Confidence 0.27 Published 1992 Journal Life Sci. Section Abstract Doc Link 1347904 Disease Relevance 0.13 Pain Relevance 0.33
Self- or partner-administration of lanreotide was associated with both IGF-1 and GH control in many patients with acromegaly (73.1% of switch patients and 30.4% of “other” patients at week 24 or early termination versus 63.3% and 4.0% at week 0, respectively; Table 2).
GH Binding (associated) of associated with acromegaly
6) Confidence 0.27 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.18 Pain Relevance 0
Self- or partner-administration of lanreotide is generally well tolerated and associated with IGF-1 and GH control in many lanreotide-naïve patients with acromegaly.



GH Binding (associated) of associated with acromegaly
7) Confidence 0.26 Published 2009 Journal Pituitary Section Abstract Doc Link PMC2855862 Disease Relevance 0.16 Pain Relevance 0.03
A series of (GH)-releasing pentapeptides and hexapeptides (GHRP's), as well as rat (rGHRH) and human (hGHRH) growth hormone-releasing hormones were tested for preferential binding to specific opioid receptors.
GH Binding (binding) of associated with opioid receptor
8) Confidence 0.25 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 2853311 Disease Relevance 0 Pain Relevance 0.65
This pool is present in a small minority of somatotropes but probably accounts for a larger portion of the GH released by pituitaries stimulated with GRF.
GH Binding (accounts) of in somatotropes
9) Confidence 0.23 Published 1988 Journal Life Sci. Section Abstract Doc Link 3123835 Disease Relevance 0 Pain Relevance 0
Furthermore, it is interesting that IGF-I alone positively influenced healing in tissues from both ambulatory and hindlimb unloaded animals, while combined GH and IGF-I only had a positive affect on tissues from HU animals.
GH Binding (combined) of in hindlimb
10) Confidence 0.17 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0 Pain Relevance 0
Interestingly, in this study the addition of GH alone, which can bind to cells via specific surface receptors activating numerous signaling pathways that direct changes in gene expression [64-67], did not offer any significant increase in mechanical properties.
GH Binding (bind) of
11) Confidence 0.16 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.14 Pain Relevance 0.04
For GH and IGF-I delivery, recombinant human GH or IGF-I (Genentech, South San Francisco, CA) was dissolved in sterile saline at a concentration of 0.25 mg/mL.
GH Binding (recombinant) of
12) Confidence 0.15 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.16 Pain Relevance 0.15
After CLP both increased specific binding of GH to the liver [29] and reduced expression of hepatic mRNA of GHRs have been demonstrated [14].
GH Binding (binding) of in liver
13) Confidence 0.10 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.38 Pain Relevance 0.03
Recent work has focused on the potential for a direct interaction between the GH–IGF-I axis and the immune system via the common cellular receptor.
GH Binding (interaction) of in immune system
14) Confidence 0.09 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.34 Pain Relevance 0.28
Thus, when stated in the following text that the GH receptor mRNA was measured, it means in fact a combination of the mRNAs for the GH receptor and the GH binding protein was assessed.
GH Binding (combination) of
15) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
GH might also modulate immune function indirectly by interacting with other hormonal systems.
GH Spec (might) Binding (interacting) of
16) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.45 Pain Relevance 0.09
After binding to these receptors, GH activates the phosphoinositide 3-kinase/Akt and NF-?
GH Binding (binding) of
17) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.50 Pain Relevance 0.26
Salmon slr appears to have reduced affinity for Gh, perhaps due to the lack of conserved site B involved in Gh binding, as found for sheep and rat [46].
Gh Binding (binding) of
18) Confidence 0.01 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553077 Disease Relevance 0 Pain Relevance 0
The Masu salmon type II ghr bound Gh exclusively [47].
Gh Binding (bound) of
19) Confidence 0.01 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553077 Disease Relevance 0 Pain Relevance 0

General Comments

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