INT73650

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Context Info
Confidence 0.03
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 2.48
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) cell cycle (Pim3)
Anatomy Link Frequency
spinal cord 2
Pim3 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 15 99.60 Very High Very High Very High
Inflammation 25 99.16 Very High Very High Very High
Enkephalin 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Repression 5 100.00 Very High Very High Very High
INFLAMMATION 20 99.16 Very High Very High Very High
Nociception 5 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose a model in which inflammation-induced phosphorylation of CREB relieves CREB repression at the DYNCRE3 site, P-CREB binds to the c-Fos promoter, and Fos/Fra, P-CREB, and P-c-Jun interact at the DYNCRE3 site to activate prodynorphin gene transcription.
DYNCRE3 site Binding (interact) of CREB associated with inflammation and repression
1) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9473689 Disease Relevance 0.50 Pain Relevance 0.29
Gel supershift studies showed that spinal cord extracts contained CREB, P-CREB, and phosphorylated c-Jun (P-c-Jun) proteins that bound to the DYNCRE3 site.
DYNCRE3 site Binding (bound) of CREB in spinal cord associated with spinal cord
2) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9473689 Disease Relevance 0.51 Pain Relevance 0.31
We propose a model in which inflammation-induced phosphorylation of CREB relieves CREB repression at the DYNCRE3 site, P-CREB binds to the c-Fos promoter, and Fos/Fra, P-CREB, and P-c-Jun interact at the DYNCRE3 site to activate prodynorphin gene transcription.
DYNCRE3 site Binding (interact) of P-CREB associated with inflammation and repression
3) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9473689 Disease Relevance 0.48 Pain Relevance 0.28
Gel supershift studies showed that spinal cord extracts contained CREB, P-CREB, and phosphorylated c-Jun (P-c-Jun) proteins that bound to the DYNCRE3 site.
DYNCRE3 site Binding (bound) of P-CREB in spinal cord associated with spinal cord
4) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9473689 Disease Relevance 0.51 Pain Relevance 0.31
We propose a model in which inflammation-induced phosphorylation of CREB relieves CREB repression at the DYNCRE3 site, P-CREB binds to the c-Fos promoter, and Fos/Fra, P-CREB, and P-c-Jun interact at the DYNCRE3 site to activate prodynorphin gene transcription.
DYNCRE3 site Binding (interact) of P-CREB associated with inflammation and repression
5) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9473689 Disease Relevance 0.48 Pain Relevance 0.28

General Comments

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