INT7366

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Context Info
Confidence 0.58
First Reported 1986
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 42
Total Number 45
Disease Relevance 7.72
Pain Relevance 14.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
pituitary 15
hypothalamus 3
somatotrophs 2
blood 1
sympathetic 1
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 148 99.92 Very High Very High Very High
Clonidine 100 99.80 Very High Very High Very High
Opioid 15 99.80 Very High Very High Very High
Neurotransmitter 57 99.54 Very High Very High Very High
adenocard 16 99.36 Very High Very High Very High
qutenza 4 99.04 Very High Very High Very High
narcan 9 99.00 Very High Very High Very High
agonist 122 98.12 Very High Very High Very High
antagonist 200 97.56 Very High Very High Very High
electroacupuncture 4 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 95 99.82 Very High Very High Very High
Thyroid Disease 20 99.80 Very High Very High Very High
Spasticity 3 99.80 Very High Very High Very High
Obesity 32 99.68 Very High Very High Very High
Cerebral Palsy 5 99.32 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

5 99.18 Very High Very High Very High
Weight Gain 2 99.08 Very High Very High Very High
Eating Disorder 27 98.56 Very High Very High Very High
Stress 246 97.88 Very High Very High Very High
Appetite Loss 5 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypothalamic GHRH content was markedly decreased 1 h after clonidine administration in mid-pubertal but not in prepubertal rats (3.67 +/- 0.23 vs 2.65 +/- 0.22 ng/hypothalamus).
Negative_regulation (decreased) of GHRH in hypothalamus associated with clonidine
1) Confidence 0.58 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 1686052 Disease Relevance 0 Pain Relevance 0.49
Determination of hypothalamic somatostatin and GHRH content in the chronic experiment 4 h after the last drug administration revealed a marked decrease in GHRH in the mid-pubertal rats and a slight decrease in the prepubertal rats (1.78 +/- 0.32 vs 3.15 +/- 0.31 and 2.01 +/- 0.30 vs 2.35 +/- 0.15 ng/hypothalamus; P less than 0.005 and P less than 0.05 respectively) whereas somatostatin levels were not altered.
Negative_regulation (decrease) of GHRH in hypothalamus associated with somatostatin
2) Confidence 0.58 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 1686052 Disease Relevance 0 Pain Relevance 0.63
In 6-day CLO-treated rats, hypothalamic GHRH content and mRNA levels were still significantly reduced, plasma GH levels were increased, but to a lesser extent than in 1- and 3-day CLO-treated rats, and pituitary GH content and mRNA reverted to control levels.
Negative_regulation (reduced) of GHRH in pituitary associated with clonidine
3) Confidence 0.58 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.95
In 1- and 3-day CLO-treated rats, by contrast, decreased hypothalamic GHRH content was coupled with a significant reduction in GHRH mRNA levels.
Negative_regulation (reduction) of GHRH associated with clonidine
4) Confidence 0.58 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.86
Reduction of both GRF and somatostatin caused blunted spontaneous GH secretion and normal GH response to arginine and clonidine.
Negative_regulation (Reduction) of GRF associated with somatostatin and clonidine
5) Confidence 0.57 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.49
Repeated administration of alpha-FMH (200 micrograms/rat, i.c.v., for 3 days) failed to modify basal and FK 33-824-induced GH secretion, caused a significant reduction in hypothalamic GHRH mRNA levels and left SRIF and GH mRNAs unchanged.
Negative_regulation (reduction) of GHRH associated with somatostatin
6) Confidence 0.56 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.29
Twenty-month-old male rats had decreased growth hormone-releasing hormone mRNA levels and a slight reduction of somatostatin mRNA levels in the hypothalamus when compared to 8-month-old counterparts.
Negative_regulation (decreased) of growth hormone-releasing hormone in hypothalamus associated with somatostatin
7) Confidence 0.54 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7950970 Disease Relevance 0.17 Pain Relevance 0.17
Short-term administration of biosynthetic human growth hormone (125 micrograms rat twice daily, i.p.) to 8-month-old rats reduced hypothalamic growth hormone-releasing hormone mRNA and increased somatostatin mRNA levels.
Negative_regulation (reduced) of growth hormone-releasing hormone associated with somatostatin
8) Confidence 0.54 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7950970 Disease Relevance 0.16 Pain Relevance 0.25
Acute administration of CLO significantly decreased hypothalamic GHRH content [leaving unaltered GHRH messenger RNA (mRNA) levels] and increased plasma GH levels; hypothalamic SS content/mRNA levels and pituitary GH content/mRNA levels remained unchanged.
Negative_regulation (decreased) of GHRH in pituitary associated with somatostatin and clonidine
9) Confidence 0.51 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.72
While much of the insensitivity to GRF may be mediated by the increased somatostatin tone reported in aging rats, a diminished pituitary cAMP response to GRF may also be an important etiological factor in the hyposomatotropinemia of the aging male rat.
Negative_regulation (diminished) of GRF in pituitary associated with aging and somatostatin
10) Confidence 0.42 Published 1986 Journal Endocrinology Section Abstract Doc Link 3009151 Disease Relevance 0.42 Pain Relevance 0.05
While basal GH secretion from the cultured pituitary cells was similar in the two groups (49.7 +/- 3.5 vs. 47.8 +/- 2.7 ng/ml X 4 h for the 2- and 18-month old rats, respectively), the GH-releasing ability of GRF was partially but significantly impaired in cells derived from both 14- and 18-month old rats; 100 nM GRF stimulated the release of 96.7 +/- 1.8 ng/ml X 4 h in the 18-month old rats as opposed to 115.0 +/- 6.0 (P less than 0.05) ng/ml X 4 h in the 2-month-old rats.
Negative_regulation (ability) of GRF in pituitary
11) Confidence 0.42 Published 1986 Journal Endocrinology Section Abstract Doc Link 3009151 Disease Relevance 0.31 Pain Relevance 0.08
In 1- and 3-day CLO-treated rats, by contrast, decreased hypothalamic GHRH content was coupled with a significant reduction in GHRH mRNA levels.
Negative_regulation (decreased) of GHRH associated with clonidine
12) Confidence 0.42 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.81
Absence of GH pulsatility during food-deprivation, coupled with no decrease in GH levels in food-deprived rats treated with GHRHab suggest that diminished GHRH pulsatility is likely during food-deprivation.
Negative_regulation (diminished) of GHRH
13) Confidence 0.42 Published 1992 Journal Life Sci. Section Abstract Doc Link 1347904 Disease Relevance 0.14 Pain Relevance 0.37
These results show that the pituitary's responsiveness to exogenous GRF is well preserved in MSG-treated rats despite prolonged and severe depletion of endogenous GRF and there exists a sex difference in the effect of MSG on GH secretion elicited by GRF.
Negative_regulation (depletion) of GRF in pituitary
14) Confidence 0.42 Published 1986 Journal Brain Res. Section Abstract Doc Link 3085872 Disease Relevance 0 Pain Relevance 0.15
These results suggest that reduction of both hypothalamic GRF and somatostatin release contribute to the impaired GH secretion in VMH lesioned rats.
Negative_regulation (reduction) of GRF associated with somatostatin
15) Confidence 0.42 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.47
The mechanisms involved in such effects were evaluated by measuring pituitary GH mRNA levels and hypothalamic levels of GH-releasing hormone (GHRH) and somatostatin (SRIF) mRNAs.
Negative_regulation (measuring) of GHRH in pituitary associated with somatostatin
16) Confidence 0.41 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.31
The mechanisms involved in such effects were evaluated by measuring pituitary GH mRNA levels and hypothalamic levels of GH-releasing hormone (GHRH) and somatostatin (SRIF) mRNAs.
Negative_regulation (measuring) of GH-releasing hormone in pituitary associated with somatostatin
17) Confidence 0.41 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.31
The higher dose of hGH diminished, though to a lower extent, hypothalamic beta EP-LI content also in intact rats, and reduced GHRH-LI content in the ME.
Negative_regulation (reduced) of GHRH
18) Confidence 0.40 Published 1987 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2957419 Disease Relevance 0 Pain Relevance 0.43
The present data provide evidence that reduced pituitary sensitivity to GRF may be a possible cause for reduced GH secretion in old animals.
Negative_regulation (reduced) of GRF in pituitary
19) Confidence 0.40 Published 1990 Journal Neurobiol. Aging Section Abstract Doc Link 2113997 Disease Relevance 0.07 Pain Relevance 0.18
In conclusion, this study demonstrates a decrease of the in vitro and in vivo pituitary response to GRF in the obese Zucker rat, suggesting a possible secondary defect at the pituitary level.
Negative_regulation (decrease) of GRF in pituitary associated with obesity
20) Confidence 0.37 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2510049 Disease Relevance 0.69 Pain Relevance 0.09

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