INT73663

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.88
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCGR3B) plasma membrane (FCGR3B)
Anatomy Link Frequency
monocyte 4
sputum 2
inflammatory monocytes 2
T-lymphocytes 2
neutrophil 2
FCGR3B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 160 98.04 Very High Very High Very High
Arthritis 264 94.36 High High
chemokine 22 92.80 High High
psoriasis 63 82.44 Quite High
headache 1 81.40 Quite High
cytokine 59 69.96 Quite High
Central nervous system 24 61.96 Quite High
transcutaneous nerve stimulation 1 50.00 Quite Low
alcohol 3 26.04 Quite Low
rheumatoid arthritis 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 112 99.96 Very High Very High Very High
INFLAMMATION 148 98.04 Very High Very High Very High
Seronegative Spondarthritis 234 94.36 High High
Urological Neuroanatomy 34 91.84 High High
Cough 3 82.96 Quite High
Psoriasis 66 82.44 Quite High
Dyspnea 4 81.92 Quite High
Hypersensitivity 16 81.68 Quite High
Headache 1 81.40 Quite High
Fever 3 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
blocks CD16 expression in a particular monocyte subset, resulting in two distinct CD14+ populations (Figures 6(d) and 6(f), upper left and right panels).
Negative_regulation (blocks) of Gene_expression (expression) of CD16 in monocyte
1) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.28 Pain Relevance 0.21
blocked CD16 expression on a subset of CD14+ monocytes.
Negative_regulation (blocked) of Gene_expression (expression) of CD16 in monocytes
2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875642 Disease Relevance 0.86 Pain Relevance 0.40
By day three (Figure 2(a)-c), CD16 surface expression decreased on cells cultured in IL4+GM-CSF (green line in Figure 2(a)-c), but increased on cells cultured in RANKL+M-CSF (pink line in Figure 2(a)-c).
Negative_regulation (decreased) of Gene_expression (expression) of CD16
3) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.08 Pain Relevance 0
We also observed evidence of diminished neutrophil activation with 2 mg FP, as it decreased the expression of CD16, a marker of neutrophil activation, compared with placebo.
Negative_regulation (decreased) of Gene_expression (expression) of CD16 in neutrophil
4) Confidence 0.19 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.58 Pain Relevance 0.18
In the present study, we found that 2 mg inhaled FP decreased the expression of CD11b, mCD14, CD16, CD64, CD86, and HLA-DR on sputum monocytic cells after O3 challenge compared with placebo treatment.
Negative_regulation (decreased) of Gene_expression (expression) of CD16 in sputum
5) Confidence 0.14 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.12 Pain Relevance 0
We also observed a significant decrease in CD16/Fc?
Negative_regulation (decrease) of Gene_expression (/) of CD16
6) Confidence 0.14 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0 Pain Relevance 0
Furthermore, CD16+ monocytes/macrophages can support HIV replication in T-lymphocytes [49] and may be sequestered by tissues expressing the ?
Negative_regulation (support) of Gene_expression (monocytes) of CD16 in T-lymphocytes associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.11 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.03 Pain Relevance 0.08
RESULTS: Non-noxious TENS1 stimulation applied segmentally produced inhibitions of the RIII reflex only during the 2-minute conditioning period.
Negative_regulation (inhibitions) of Gene_expression (produced) of RIII
8) Confidence 0.10 Published 1998 Journal Arch Phys Med Rehabil Section Body Doc Link 9474003 Disease Relevance 0 Pain Relevance 0
We found both CD14+ and CD16+ monocytes significantly reduced after storage (the latter, thought to represent inflammatory monocytes [9] in humans were more markedly affected).
Negative_regulation (reduced) of Gene_expression (monocytes) of CD16 in inflammatory monocytes associated with inflammation
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2872666 Disease Relevance 0.93 Pain Relevance 0.13

General Comments

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