INT73667

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.38
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F5) extracellular region (F5) cell adhesion (F5)
plasma membrane (F5)
F5 (Homo sapiens)
F5 - G1691A (1)
Pain Link Frequency Relevance Heat
Inflammation 20 95.20 Very High Very High Very High
imagery 2 77.36 Quite High
cytokine 1 76.80 Quite High
abdominal pain 2 71.60 Quite High
Inflammatory response 1 54.32 Quite High
Pain 5 50.00 Quite Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombophilia 39 99.96 Very High Very High Very High
INFLAMMATION 21 95.20 Very High Very High Very High
Thrombosis 9 94.40 High High
Apoptosis 3 93.44 High High
Pregnancy Complications 24 91.84 High High
Spontaneous Abortion 9 88.16 High High
Eclampsia 34 85.12 High High
Syndrome 1 83.76 Quite High
Pressure And Volume Under Development 2 82.96 Quite High
Cognitive Disorder 4 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The search was updated in February 2010.We identified the following relevant MeSH and free terms for the exposures and outcomes by literature review and by recommendations from experts in the field (MAR, MC): Thrombophilia, activated protein C resistance (APCR), FVL, and PGM (PGM, PGV, G202110A, G1691A) for the exposure.
Positive_regulation (activated) of FVL associated with thrombophilia
1) Confidence 0.60 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.85 Pain Relevance 0
This last suggestion will need to be confirmed by future studies that examine the responses of F5 PTNs whose discharge is suppressed by action observation, during performance of other tasks requiring the withholding of a motor response.


Spec (examine) Positive_regulation (responses) of F5
2) Confidence 0.16 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0.07 Pain Relevance 0
Finally, a striking finding of this study is the relatively high proportion of F5 PTNs tested that showed mirror-like activity.
Positive_regulation (proportion) of F5
3) Confidence 0.16 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0.08 Pain Relevance 0
APC conveys its anticoagulant function mainly by proteolytic inactivation of coagulation activated factor V and activated factor VIII.
Positive_regulation (inactivation) of coagulation activated factor V
4) Confidence 0.09 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.38 Pain Relevance 0.28
Ten patients had one or more thrombophilic traits (there were two patients with protein C deficiency, five with resistance to activated protein C and/or the mutant Factor V Leiden gene, and four with high anticardiolipin antibodies).
Positive_regulation (resistance) of Factor V Leiden gene
5) Confidence 0.06 Published 1998 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 9474617 Disease Relevance 0.18 Pain Relevance 0
Ten patients had one or more thrombophilic traits (there were two patients with protein C deficiency, five with resistance to activated protein C and/or the mutant Factor V Leiden gene, and four with high anticardiolipin antibodies).
Positive_regulation (activated) of Factor V Leiden gene
6) Confidence 0.06 Published 1998 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 9474617 Disease Relevance 0.18 Pain Relevance 0
In 11 of the 22 patients (50%) inherited prothrombotic risk factors were detected as follows: 4 were heterozygous for factor V G1691A, 2 had protein S deficiency, one had protein S deficiency and was heterozygous for factor V G1691A, and 4 were homozygous for MTHFR C677T.
Positive_regulation (heterozygous) of factor V G1691A (G1691A)
7) Confidence 0.03 Published 1999 Journal Thromb. Haemost. Section Abstract Doc Link 10494756 Disease Relevance 0.64 Pain Relevance 0.11

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