INT73670

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 128
Total Number 129
Disease Relevance 123.79
Pain Relevance 24.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
endothelial cells 16
monocyte 9
macrophages 7
lung 6
eosinophils 6
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2254 100.00 Very High Very High Very High
Central nervous system 355 100.00 Very High Very High Very High
chemokine 318 100.00 Very High Very High Very High
Inflammatory mediators 43 100.00 Very High Very High Very High
cytokine 1026 99.92 Very High Very High Very High
aspirin 426 99.74 Very High Very High Very High
licofelone 8 99.32 Very High Very High Very High
Multiple sclerosis 179 99.24 Very High Very High Very High
Inflammatory response 232 99.06 Very High Very High Very High
cocaine 10 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2522 100.00 Very High Very High Very High
Adhesions 972 100.00 Very High Very High Very High
Cancer 795 100.00 Very High Very High Very High
Necrosis 185 100.00 Very High Very High Very High
Multiple Sclerosis 595 99.96 Very High Very High Very High
Viral Meningitis 115 99.96 Very High Very High Very High
Rheumatoid Arthritis 615 99.84 Very High Very High Very High
Experimental Melanoma 4 99.84 Very High Very High Very High
Burns 76 99.82 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 582 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of infiltrated eosinophils and the expression of vascular cell adhesion molecule-l (VCAM-1) in the conjunctiva were quantified by the staining method of Hansel and immunohistochemical analysis.
Gene_expression (expression) of vascular cell adhesion molecule-l in eosinophils
1) Confidence 0.78 Published 2006 Journal Jpn. J. Ophthalmol. Section Body Doc Link 16767373 Disease Relevance 0 Pain Relevance 0
The number of infiltrated eosinophils and the expression of vascular cell adhesion molecule-l (VCAM-1) in the conjunctiva were quantified by the staining method of Hansel and immunohistochemical analysis.
Gene_expression (expression) of VCAM-1 in eosinophils
2) Confidence 0.78 Published 2006 Journal Jpn. J. Ophthalmol. Section Body Doc Link 16767373 Disease Relevance 0 Pain Relevance 0
In both strains of mice, the number of infiltrated eosinophils increased over time, with VCAM-1 expression on vascular endothelial cells peaking at 9 h after treatment, and decreasing gradually within 24 h after treatment.
Gene_expression (expression) of VCAM-1 in eosinophils
3) Confidence 0.78 Published 2006 Journal Jpn. J. Ophthalmol. Section Body Doc Link 16767373 Disease Relevance 0 Pain Relevance 0
In both the neuropeptide-depleted and the DSCG-treated groups, eosinophil infiltration and VCAM-1 expression were suppressed in comparison with the nontreated group.
Gene_expression (expression) of VCAM-1 in eosinophil
4) Confidence 0.78 Published 2006 Journal Jpn. J. Ophthalmol. Section Body Doc Link 16767373 Disease Relevance 0 Pain Relevance 0
The endothelium overlying atherosclerotic lesions expresses P-selectin and the shoulder regions express vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), which is also expressed on endothelium in regions not prone to plaque development.
Neg (not) Gene_expression (expressed) of VCAM-1 in endothelium associated with atherosclerosis and adhesions
5) Confidence 0.71 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.18 Pain Relevance 0.17
The endothelium overlying atherosclerotic lesions expresses P-selectin and the shoulder regions express vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), which is also expressed on endothelium in regions not prone to plaque development.
Gene_expression (express) of VCAM-1 in endothelium associated with atherosclerosis and adhesions
6) Confidence 0.71 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.16 Pain Relevance 0.16
Treatment with high dose ASA resulted in a decreased VCAM-1 expression below and at the bifurcation (p?
Gene_expression (expression) of VCAM-1 associated with aspirin
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.11 Pain Relevance 0.21
High dose ASA, but not NCX 4016, inhibited endothelial cell expression of VCAM-1 and thrombomodulin in the carotid arteries at 4 weeks after irradiation; eNOS and ICAM-1 levels were unchanged.
Gene_expression (expression) of VCAM-1 in endothelial cell
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943480 Disease Relevance 0.52 Pain Relevance 0.27
Gene expression levels of inflammatory endothelial cell activation (P-selectin, E-selectin, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1) and hypoxia-responsive genes (vascular endothelial growth factor and hypoxia-inducible factor 1alpha) were quantified in kidney, liver, lung, brain, and heart tissue by quantitative reverse-transcription-polymerase chain reaction.
Gene_expression (expression) of vascular cell adhesion molecule 1 in lung associated with inflammation, hypoxia and adhesions
9) Confidence 0.62 Published 2008 Journal Shock Section Abstract Doc Link 17704730 Disease Relevance 1.72 Pain Relevance 0.23
The upregulated expression of ICAM-1 and VCAM-1 on the microvessels of the CVOs during EAE suggests that the same molecules mediating immune cell entry across the BBB might be involved in guiding inflammatory cells into the CVOs.
Gene_expression (expression) of VCAM-1 in immune cell associated with multiple sclerosis and inflammation
10) Confidence 0.62 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.80 Pain Relevance 0.20
4-integrins, namely intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1, are expressed on the microvascular endothelial cells within the CVOs.
Gene_expression (expressed) of vascular cell adhesion molecule in endothelial cells associated with adhesions
11) Confidence 0.62 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.89 Pain Relevance 0.04
Whereas ICAM-1 was detected on the luminal surface of the capillaries of all CVOs investigated (Figs. 7, 8 and data not shown), VCAM-1 although present on the luminal surface of microvessels in the SFO, OVLT and AP (Fig. 7 and data not shown) could not be detected on the luminal surface of the capillaries within the ME (Fig. 8).
Neg (not) Gene_expression (detected) of VCAM-1
12) Confidence 0.62 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.65 Pain Relevance 0.04
Basal vascular superoxide production and NAD(P)H oxidase activity, vascular cell adhesion molecule-1 expression, and macrophage infiltration were significantly increased only in DOCA-salt +/+ mice.
Gene_expression (expression) of vascular cell adhesion molecule-1 in macrophage associated with adhesions
13) Confidence 0.62 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17142347 Disease Relevance 0.58 Pain Relevance 0.17
The endothelium overlying atherosclerotic lesions expresses P-selectin and the shoulder regions express vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), which is also expressed on endothelium in regions not prone to plaque development.
Gene_expression (express) of vascular cell adhesion molecule-1 in endothelium associated with atherosclerosis and adhesions
14) Confidence 0.62 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.16 Pain Relevance 0.16
The endothelium overlying atherosclerotic lesions expresses P-selectin and the shoulder regions express vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), which is also expressed on endothelium in regions not prone to plaque development.
Neg (not) Gene_expression (expressed) of vascular cell adhesion molecule-1 in endothelium associated with atherosclerosis and adhesions
15) Confidence 0.62 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.19 Pain Relevance 0.17
In addition to the reduction in percentage of endothelial cells expressing VCAM-1, there was a reduction in the intensity of positive immunostaining below the bifurcation (p?
Gene_expression (expressing) of VCAM-1 in endothelial cells
16) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0 Pain Relevance 0.16
In SCID mice with HIVE, human and mouse TNF alpha, and mouse IL-6, VEGF, VCAM-1 and E-selectin were expressed at high levels.
Gene_expression (expressed) of VCAM-1 associated with severe combined immunodeficiency and viral meningitis
17) Confidence 0.57 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9475112 Disease Relevance 1.97 Pain Relevance 0.16
The expression of interleukin-1 (IL-1 beta, IL-6, IL-10), tumor necrosis factors-alpha (TNF alpha), vascular endothelial growth factor (VEGF), and adhesion molecules (E-selectin, intracellular cell adhesion molecule (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)) in encephalitic brains of mice and humans was evaluated by semi-quantitative polymerase chain reaction (PCR).
Gene_expression (expression) of VCAM-1 in brains associated with necrosis, cancer and adhesions
18) Confidence 0.57 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9475112 Disease Relevance 2.42 Pain Relevance 0.15
IL-4 plays an important role in the production of IgE, but mediates also other pathways such as the differentiation of Th-lymphocytes, the ability to induce the expression of vascular cell adhesion molecule 1 (VCAM-1) and the production of mucus in the asthmatic airway [30].
Gene_expression (expression) of VCAM-1 in lymphocytes associated with asthma and adhesions
19) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935354 Disease Relevance 0.76 Pain Relevance 0.06
IL-4 plays an important role in the production of IgE, but mediates also other pathways such as the differentiation of Th-lymphocytes, the ability to induce the expression of vascular cell adhesion molecule 1 (VCAM-1) and the production of mucus in the asthmatic airway [30].
Gene_expression (expression) of vascular cell adhesion molecule 1 in lymphocytes associated with asthma and adhesions
20) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935354 Disease Relevance 0.76 Pain Relevance 0.06

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