INT73673

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.25
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mtap2) intracellular (Mtap2) protein complex (Mtap2)
cytoplasm (Mtap2)
Anatomy Link Frequency
neuronal 2
dendrites 1
neurons 1
brain 1
Mtap2 (Mus musculus)
Pain Link Frequency Relevance Heat
glial activation 3 98.36 Very High Very High Very High
Enkephalin 6 93.92 High High
Inflammatory response 4 93.52 High High
Neuropeptide 2 93.20 High High
substance P 3 92.44 High High
Inflammation 74 89.44 High High
Hippocampus 86 85.96 High High
projection neuron 1 85.40 High High
Substantia nigra 17 70.16 Quite High
nMDA receptor 7 70.04 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 95 99.74 Very High Very High Very High
Targeted Disruption 591 98.40 Very High Very High Very High
Viral Meningitis 16 95.44 Very High Very High Very High
Alzheimer's Dementia 484 95.08 Very High Very High Very High
INFLAMMATION 81 93.52 High High
Vascular Disease 48 90.32 High High
Severe Combined Immunodeficiency 12 88.36 High High
Death 83 84.16 Quite High
Adhesions 15 82.80 Quite High
Sprains And Strains 8 82.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreactivity for microtubule-associated protein 2 was decreased at the periphery of the lesion 10 h after quinolinate injection.
Negative_regulation (decreased) of microtubule-associated protein 2
1) Confidence 0.32 Published 1999 Journal Neuroscience Section Abstract Doc Link 10473250 Disease Relevance 0.14 Pain Relevance 0.65
Expression levels of MAP2 were also decreased in all brain regions of A?
Negative_regulation (levels) of MAP2 in brain
2) Confidence 0.27 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.14 Pain Relevance 0.06
The homozygous deletion of the superoxide dismutase 2 (SOD2), a mitochondrial enzyme implicated in the protection against oxidative damage, worsened the cognitive deficit and decreased the microtubule-associated protein 2 (MAP2) immunoreactivity, a sign of dendritic loss.
Negative_regulation (decreased) of MAP2 associated with cognitive disorder
3) Confidence 0.23 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.95 Pain Relevance 0
The homozygous deletion of the superoxide dismutase 2 (SOD2), a mitochondrial enzyme implicated in the protection against oxidative damage, worsened the cognitive deficit and decreased the microtubule-associated protein 2 (MAP2) immunoreactivity, a sign of dendritic loss.
Negative_regulation (decreased) of microtubule-associated protein 2 associated with cognitive disorder
4) Confidence 0.23 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.95 Pain Relevance 0
deposits and improved the loss of synaptophysin and of MAP2 immunoreactivity.
Negative_regulation (loss) of MAP2
5) Confidence 0.23 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 1.04 Pain Relevance 0.24
Laser scanning confocal microscopy performed to assess the associated neuronal damage showed that microtubule associated protein-2 (MAP-2) immunoreactive dendrites were significantly reduced in both the ipsilateral and contralateral hemispheres of encephalitic mice.
Negative_regulation (reduced) of MAP-2 in neuronal
6) Confidence 0.19 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9475112 Disease Relevance 1.73 Pain Relevance 0.08
Laser scanning confocal microscopy performed to assess the associated neuronal damage showed that microtubule associated protein-2 (MAP-2) immunoreactive dendrites were significantly reduced in both the ipsilateral and contralateral hemispheres of encephalitic mice.
Negative_regulation (reduced) of microtubule associated protein-2 in neuronal
7) Confidence 0.19 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9475112 Disease Relevance 1.75 Pain Relevance 0.08
The LPS treatment reduced the THir cells, but not microtubule-associated protein-2 (MAP-2), a marker of all neurons.
Negative_regulation (reduced) of MAP-2 in neurons
8) Confidence 0.16 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280408 Disease Relevance 1.08 Pain Relevance 0.17
In order to standardize the labelling by PTK2BpY402 to the loss of MAP2A labelling in dendrites of 10-12 mo-old Tg mice, we examined the ratio of labelling (pixel density) by anti-PTK2BpY402 to that of anti-MAP2A.
Negative_regulation (loss) of MAP2A in dendrites associated with targeted disruption
9) Confidence 0.04 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.48 Pain Relevance 0.11

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