INT73674

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 11.23
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
endothelial cells 8
brains 4
stromal cells 2
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 128 98.30 Very High Very High Very High
metalloproteinase 24 98.04 Very High Very High Very High
Inflammation 287 95.64 Very High Very High Very High
Inflammatory response 28 93.80 High High
anesthesia 6 76.16 Quite High
corticosteroid 6 65.92 Quite High
agonist 10 64.16 Quite High
chemokine 28 55.92 Quite High
antagonist 23 5.00 Very Low Very Low Very Low
Arthritis 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 100 100.00 Very High Very High Very High
Atherosclerosis 88 100.00 Very High Very High Very High
Adhesions 48 100.00 Very High Very High Very High
Necrosis 21 100.00 Very High Very High Very High
Viral Meningitis 16 99.76 Very High Very High Very High
Hypothermia 46 99.00 Very High Very High Very High
Severe Combined Immunodeficiency 12 97.16 Very High Very High Very High
INFLAMMATION 331 95.64 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 95.52 Very High Very High Very High
Asthma 43 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of interleukin-1 (IL-1 beta, IL-6, IL-10), tumor necrosis factors-alpha (TNF alpha), vascular endothelial growth factor (VEGF), and adhesion molecules (E-selectin, intracellular cell adhesion molecule (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)) in encephalitic brains of mice and humans was evaluated by semi-quantitative polymerase chain reaction (PCR).
Regulation (evaluated) of Gene_expression (expression) of VCAM-1 in brains associated with necrosis, cancer and adhesions
1) Confidence 0.33 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9475112 Disease Relevance 2.43 Pain Relevance 0.18
Interestingly, a role for NF-kappaB regulating VCAM1 expression has been proposed [33].
Regulation (role) of Gene_expression (expression) of VCAM1
2) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.27 Pain Relevance 0.12
Interestingly, a role for NF-kappaB regulating VCAM1 expression has been proposed [33].
Regulation (regulating) of Gene_expression (expression) of VCAM1
3) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.27 Pain Relevance 0.12
The expression of interleukin-1 (IL-1 beta, IL-6, IL-10), tumor necrosis factors-alpha (TNF alpha), vascular endothelial growth factor (VEGF), and adhesion molecules (E-selectin, intracellular cell adhesion molecule (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)) in encephalitic brains of mice and humans was evaluated by semi-quantitative polymerase chain reaction (PCR).
Regulation (evaluated) of Gene_expression (expression) of vascular cell adhesion molecule-1 in brains associated with necrosis, cancer and adhesions
4) Confidence 0.29 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9475112 Disease Relevance 2.43 Pain Relevance 0.18
is a multifunctional proinflammatory cytokine, and a chemoattractant for neutrophils and eosinophils.3 It increases the cytotoxic effect of eosinophils on endothelial cells,4 epithelial expression of adhesion molecules, such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1),6 and the contractile function of smooth muscles,7 and is involved in the activation of T cells.5 Howarth et al.8 reported that TNF-?
Regulation (effect) of Gene_expression (expression) of vascular cell adhesion molecule 1 in endothelial cells associated with adhesions and cytokine
5) Confidence 0.19 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.69 Pain Relevance 0.40
In addition, hypothermic temperatures were found associated with increased P-selectin shedding, although cardiopulmonary bypass patients did not reveal differences in circulating levels of ICAM-1 and VCAM-1 during normothermia and hypothermia [20].
Regulation (circulating) of Gene_expression (levels) of VCAM-1 associated with hypothermia
6) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.88 Pain Relevance 0.15
PPAR gamma may also affect the recruitment of monocytes in atherosclerotic lesions as it is involved in the expression of VCAM-1 and intracellular adhesion molecule-1 in vascular endothelial cells[62].


Spec (may) Regulation (affect) of Gene_expression (expression) of VCAM-1 in endothelial cells associated with atherosclerosis and adhesions
7) Confidence 0.12 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.81 Pain Relevance 0.18
cause down regulation of both IL-7 [40] and VCAM-1 gene expression [41] by stromal cells, interfering with the self-renewal and differentiation of B-cell precursors.
Regulation (regulation) of Gene_expression (expression) of VCAM-1 in stromal cells
8) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.41 Pain Relevance 0.04
Shen and co-workers (1996) have shown that cigarette smoke condensate induces the expression of a subset of cell adhesion molecules, such as intercellular adhesion molecule (ICAM-1), endothelial leukocyte adhesion molecule 1 (ELAM-1), and vascular cell adhesion molecule (VCAM-1) in human umbilical vascular endothelial cells associated with an increase in the binding activity of NF-?
Regulation (intercellular) of Gene_expression (expression) of VCAM-1 in endothelial cells associated with adhesions
9) Confidence 0.09 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.24 Pain Relevance 0.10
PPAR gamma may also affect the recruitment of monocytes in atherosclerotic lesions as it is involved in the expression of VCAM-1 and intracellular adhesion molecule-1 in vascular endothelial cells[62].


Regulation (involved) of Gene_expression (expression) of VCAM-1 in endothelial cells associated with atherosclerosis and adhesions
10) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.79 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox