INT73682

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Context Info
Confidence 0.18
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 1.22
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Pprc1) nucleus (Pprc1)
Anatomy Link Frequency
neurons 2
nucleus accumbens 1
myometrium 1
Pprc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 6 99.68 Very High Very High Very High
agonist 59 99.44 Very High Very High Very High
Locus ceruleus 3 99.40 Very High Very High Very High
Ventral tegmentum 3 98.60 Very High Very High Very High
Dismenorea 6 98.32 Very High Very High Very High
narcan 6 97.84 Very High Very High Very High
Hippocampus 3 97.64 Very High Very High Very High
withdrawal 9 96.96 Very High Very High Very High
Morphine 19 92.60 High High
addiction 3 59.20 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 6 98.32 Very High Very High Very High
Prostate Cancer 20 92.48 High High
Breast Cancer 23 91.08 High High
Targeted Disruption 51 74.32 Quite High
Cancer 21 62.60 Quite High
Syndrome 12 60.56 Quite High
Shock 6 55.80 Quite High
Congenital Anomalies 7 37.60 Quite Low
Increased Venous Pressure Under Development 4 37.08 Quite Low
Pressure Volume 2 Under Development 24 35.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite receiving more PRC units during CPB, group B patients had lower intraoperative Hct values (Table 8).
Gene_expression (units) of PRC
1) Confidence 0.18 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2845571 Disease Relevance 0 Pain Relevance 0
Indications for perioperative PRC transfusion
Gene_expression (transfusion) of PRC
2) Confidence 0.18 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2845571 Disease Relevance 0 Pain Relevance 0
Table 4 presents data after dividing patients within each group, in two subgroups, based on whether they received intraoperative PRC transfusions or not.
Gene_expression (transfusions) of PRC
3) Confidence 0.18 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2845571 Disease Relevance 0 Pain Relevance 0
The model explains nearly 21.5% (Nagelkerke R2, Table 6) of the observed variability regarding receiving a transfusion or not, and shows that the likelihood of PRC transfusion is 3.12 times greater in group B compared to group A.
Gene_expression (transfusion) of PRC
4) Confidence 0.18 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2845571 Disease Relevance 0 Pain Relevance 0
Cell membrane levels of IGF-I-R and EGF-R, cytosol and nuclear oestrogen (ERc and ERn, respectively) and cytosol progesterone (PRc) receptors were assayed in 37 samples of adenomyosis foci, 46 of endometrium and 50 of myometrium using the radioligand method.
Gene_expression (levels) of PRc in myometrium associated with dismenorea
5) Confidence 0.02 Published 1998 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 9476071 Disease Relevance 0.40 Pain Relevance 0.40
Our results indicate that the expression levels of aldolase C and PRC8 proteins were altered in a time- and region-specific manner, and suggest that they could be implicated in the molecular changes underlying adaptations of neurons observed with chronic morphine treatment.
Gene_expression (expression) of PRC8 in neurons associated with morphine
6) Confidence 0.01 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345208 Disease Relevance 0 Pain Relevance 0.73
Our results indicate that the expression levels of aldolase C and PRC8 proteins were altered in a time- and region-specific manner, and suggest that they could be implicated in the molecular changes underlying adaptations of neurons observed with chronic morphine treatment.
Gene_expression (levels) of PRC8 in neurons associated with morphine
7) Confidence 0.01 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345208 Disease Relevance 0 Pain Relevance 0.72
In addition, expression of PRC8 in the nucleus accumbens tissue after spontaneous or naloxone-precipitated withdrawal was determined using immunohistochemical staining.
Gene_expression (expression) of PRC8 in nucleus accumbens associated with nucleus accumbens, narcan and withdrawal
8) Confidence 0.01 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345208 Disease Relevance 0 Pain Relevance 0.75
Alternatively, the biological role of a coactivator can also be assessed by using a siRNA to extinguish expression of the coactivator in vivo.
Gene_expression (expression) of coactivator
9) Confidence 0.01 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.12 Pain Relevance 0
Cloning, domain structure, functional organization and expression of the nuclear receptor coregulator/coactivator, NCoA6
Gene_expression (expression) of coactivator
10) Confidence 0.01 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.13 Pain Relevance 0
In order to identify AR coregulators whose expression is regulated by androgens, we measured the expression of 20 putative coactivators: SRC1 (alias NCOA1 nuclear receptor coactivator 1), TIF2 (alias NCOA2 nuclear receptor coactivator 2), PIAS1 (protein inhibitor of activated STAT, 1), PIASx (alias PIAS2 protein inhibitor of activated STAT, 2), ARIP4 (alias RAD54L2 RAD54-like 2 (S. cerevisiae)), BRCA1 (breast cancer 1, early onset), ?
Gene_expression (expression) of coactivator associated with breast cancer
11) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.57 Pain Relevance 0.03
The

complex consisting of PPAR and coactivator was then identified with the

Gene_expression (consisting) of coactivator
12) Confidence 0.00 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0.16

General Comments

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