INT73706

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Context Info
Confidence 0.02
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 2
Lhyp (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 10 99.84 Very High Very High Very High
Inflammation 58 91.20 High High
Inflammatory marker 1 88.88 High High
substance P 2 84.64 Quite High
Neuropeptide 1 81.48 Quite High
Catecholamine 1 80.56 Quite High
cytokine 10 45.20 Quite Low
qutenza 2 44.24 Quite Low
Potency 5 9.76 Low Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 1 96.04 Very High Very High Very High
Targeted Disruption 3 94.24 High High
Neurogenic Inflammation 2 91.20 High High
INFLAMMATION 53 88.56 High High
Lung Injury 1 85.84 High High
Asthma 42 85.20 High High
Pulmonary Disease 3 72.72 Quite High
Disease 10 5.00 Very Low Very Low Very Low
Graft Vs Host Disease 7 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To generate mice with an increased innervation of the airways, we placed the gene that encodes nerve growth factor (NGF) under control of the lung-specific Clara-cell secretory protein (CCSP) promoter.
Regulation (control) of lung-specific in lung associated with nerve growth factor
1) Confidence 0.02 Published 1998 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 9476901 Disease Relevance 0.61 Pain Relevance 0.55
Evaluation of lung histology in mice sensitized and challenged with saline showed relatively little change in lung morphology (1B) compared with ovalbumin-challenged mice, which showed significant epithelial cell hyperplasia and thickening of the airway consistent with other published observations of this model (1C).


Neg (little) Regulation (change) of lung in lung associated with hyperplasia
2) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2987779 Disease Relevance 0.54 Pain Relevance 0.08

General Comments

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