INT73709

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.39
Pain Relevance 6.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Mastl) cytoskeleton (Mastl) nucleus (Mastl)
cell cycle (Mastl) cell division (Mastl) kinase activity (Mastl)
Anatomy Link Frequency
brain 1
immune system 1
microglial cells 1
Mastl (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 104 100.00 Very High Very High Very High
tolerance 71 100.00 Very High Very High Very High
Morphine 61 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
Neuropathic pain 3 99.16 Very High Very High Very High
analgesia 25 98.92 Very High Very High Very High
Cannabinoid 134 98.52 Very High Very High Very High
Analgesic 67 98.52 Very High Very High Very High
antinociception 17 97.92 Very High Very High Very High
Antinociceptive 9 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 3 99.44 Very High Very High Very High
Neuropathic Pain 3 99.16 Very High Very High Very High
Arthritis 10 98.80 Very High Very High Very High
Spasticity 3 98.32 Very High Very High Very High
Amnesia 2 96.40 Very High Very High Very High
Disease 30 94.28 High High
Targeted Disruption 19 94.00 High High
Neurodegenerative Disease 173 93.60 High High
Motor Neuron Diseases 44 91.72 High High
Demyelinating Disease 56 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unfortunately, the flexible nature of this side chain has hampered efforts to elucidate the precise nature of the interaction of THC with its receptors.
THC Binding (interaction) of
1) Confidence 0.40 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10454479 Disease Relevance 0 Pain Relevance 0.23
Our aim was to characterize the interaction between Delta9-THC and propofol in terms of sedation and analgesia.
Delta9-THC Binding (interaction) of associated with sleep disorders and analgesia
2) Confidence 0.31 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18635473 Disease Relevance 0.27 Pain Relevance 0.24
As expected, the treatment of cultured microglial cells with THC, CP55940 and JWH-015 significantly inhibited CD40 expression induced by IFN-?
THC Binding (microglial cells) of in microglial cells
3) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.09
However, previous studies of the Delta(9)-THC/morphine interaction were performed using normal mice or rats and evaluated acute thermal antinociception.
THC Binding (interaction) of associated with antinociception and morphine
4) Confidence 0.04 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17498686 Disease Relevance 0.39 Pain Relevance 0.81
The isobolographic analysis indicated a synergistic interaction between Delta(9)-THC and morphine in both the non-arthritic and the arthritic rats.
THC Binding (interaction) of associated with arthritis and morphine
5) Confidence 0.04 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17498686 Disease Relevance 0.67 Pain Relevance 1.23
Experiments with THC and CBD in different concentrations might help to unravel the complex pattern of such treatments and should, as our results suggest, include measures of adult neurogenesis.
THC Binding (Experiments) of associated with neurodegenerative disease
6) Confidence 0.04 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.94 Pain Relevance 0.26
In a different set of experiments, 30 female wild-type mice were housed in standard cages and fed with either a diet supplemented with THC or CBD or without any drug (CTR) for 6 weeks (chronic treatment).
THC Binding (supplemented) of
7) Confidence 0.04 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.24 Pain Relevance 0
WIN55,212-2 desensitized its own analgesic response and, as expected for agonists sharing the receptor, it was also desensitized by other CB1R agonists, such as methanandamide, ACEA, and THC.
THC Binding (desensitized) of associated with analgesic and agonist
8) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.57
Bidirectional cross-tolerance between the kappa opioids and delta9-THC implies that a common mechanism may be responsible for tolerance expression.
delta9-THC Binding (cross-tolerance) of associated with tolerance and opioid
9) Confidence 0.02 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9476987 Disease Relevance 0 Pain Relevance 0.74
Bidirectional cross-tolerance between the kappa opioids and delta9-THC implies that a common mechanism may be responsible for tolerance expression.
delta9-THC Binding (cross-tolerance) of associated with tolerance and opioid
10) Confidence 0.02 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9476987 Disease Relevance 0 Pain Relevance 0.74
The receptor which specifically binds Delta9-tetrahydrocannabinol (Delta9-THC) and related compounds in rat and human brain has been discovered and cloned by a number of researchers.
Delta9-THC Binding (binds) of in brain
11) Confidence 0.01 Published 2003 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 14683467 Disease Relevance 0 Pain Relevance 0.39
It is known that THC binds to receptors in the CNS known as CB1 and that a second subtype of these receptors CB2 are mainly present in the periphery in the normal state, particularly on macrophage cells of the immune system [13].
THC Binding (binds) of in immune system
12) Confidence 0.01 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 0.88 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox