INT73723

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.37
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tff3) proteinaceous extracellular matrix (Tff3)
Anatomy Link Frequency
brain 3
hippocampus 2
oesophagus 1
lateral 1
goblet cells 1
Tff3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 10 99.92 Very High Very High Very High
alcohol 16 99.84 Very High Very High Very High
c fibre 10 99.78 Very High Very High Very High
Hippocampus 12 99.52 Very High Very High Very High
cocaine 16 99.42 Very High Very High Very High
cINOD 11 97.48 Very High Very High Very High
Sciatic nerve 2 94.64 High High
addiction 4 87.96 High High
tolerance 3 83.24 Quite High
Inflammation 64 81.80 Quite High
Disease Link Frequency Relevance Heat
Ulcers 7 97.20 Very High Very High Very High
Nicotine Addiction 4 93.72 High High
Nociception 2 90.64 High High
Drug Dependence 4 87.96 High High
INFLAMMATION 66 81.80 Quite High
Inflammatory Bowel Disease 47 80.24 Quite High
Disease 24 65.00 Quite High
Wound Healing 2 55.84 Quite High
Hiatal Hernia 4 47.44 Quite Low
Obesity 7 43.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with this hypothesis is our finding that the majority of brain regions responding with ITF expression to alcohol administration do not respond to voluntary alcohol self-administration in animals.
Gene_expression (expression) of ITF in brain associated with alcohol
1) Confidence 0.77 Published 2000 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 11200183 Disease Relevance 0 Pain Relevance 0.42
Anesthesia can block induction of ITFs by cocaine and alcohol suggesting that ITF expression in a majority of brain regions is more sensitive to secondary effects than to pharmacological effects of these drugs.
Gene_expression (expression) of ITF in brain associated with anesthesia, alcohol and cocaine
2) Confidence 0.77 Published 2000 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 11200183 Disease Relevance 0 Pain Relevance 0.39
MK-801 blocked these changes in ITF expressions, but it could also cause the C-fibre stimulations to induce c-Fos and c-Jun in specific areas of the hippocampus.
Gene_expression (expressions) of ITF in hippocampus associated with c fibre and hippocampus
3) Confidence 0.75 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0 Pain Relevance 0.52
Here we examine the effects of single, repeated and simultaneous C-fibre inputs on ITF expressions in the rat hippocampus.
Gene_expression (expressions) of ITF in hippocampus associated with c fibre and hippocampus
4) Confidence 0.75 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.09 Pain Relevance 0.46
Changes in neuronal activity were assessed by immunohistochemical analysis of expression of an inducible transcription factor (ITF), c-Fos, in the brain of rats habituated to repeated pentobarbital anesthesia or saline administration.
Gene_expression (expression) of ITF in brain associated with anesthesia
5) Confidence 0.71 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986339 Disease Relevance 0.09 Pain Relevance 0.51
It is not clear whether the suppressive effects of anesthesia on ITF expression in other areas are mediated by activation of lateral habenula, or are independent of this event.
Gene_expression (expression) of ITF in lateral associated with anesthesia
6) Confidence 0.71 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986339 Disease Relevance 0 Pain Relevance 0.65
Figure 3 shows haematoxylin and eosin and trefoil factor 3 staining of the Cytosponge specimen from a representative segment of tissue from a patient with BarrettÂ’s oesophagus.
Gene_expression (staining) of trefoil factor 3 in oesophagus
7) Confidence 0.15 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2938899 Disease Relevance 0.16 Pain Relevance 0
Any glandular cells with trefoil factor 3 staining were considered as positive and to make the result as robust and objective as possible we used no intensity cut offs.
Gene_expression (staining) of trefoil factor 3
8) Confidence 0.13 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2938899 Disease Relevance 0 Pain Relevance 0.03
Three trefoil peptides are expressed constitutively by epithelial cells in specific regions of the GI tract: pS2 (gastric), spasmolytic polypeptide (SP, gastric and Brunner's glands), and intestinal trefoil factor (ITF, goblet cells).
Gene_expression (expressed) of intestinal trefoil factor in goblet cells
9) Confidence 0.11 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479633 Disease Relevance 0.16 Pain Relevance 0.10
In cryoprobe ulceration, rSP mRNA abundance doubles within 2 h, with rITF mRNA becoming detectable after 2-3 days.
Gene_expression (detectable) of rITF
10) Confidence 0.09 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479633 Disease Relevance 0.22 Pain Relevance 0.08
Expression of antimicrobial or restitutional peptides, such as defensins [23] or trefoil factor family 3 [22], is reduced.
Gene_expression (Expression) of trefoil factor family 3
11) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.66 Pain Relevance 0.20

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