INT7375

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Context Info
Confidence 0.43
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.37
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
Anatomy Link Frequency
PVH 2
collecting tubules 2
AVP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 99.68 Very High Very High Very High
narcan 9 99.62 Very High Very High Very High
tetrodotoxin 3 99.04 Very High Very High Very High
agonist 6 99.00 Very High Very High Very High
opiate 3 96.88 Very High Very High Very High
Endogenous opioid 6 96.60 Very High Very High Very High
butorphanol 2 85.96 High High
Clonidine 1 72.64 Quite High
medulla 1 61.48 Quite High
Catecholamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 5 100.00 Very High Very High Very High
Hypotension 7 56.20 Quite High
Hypertension 1 26.48 Quite Low
Endotoxemia 9 23.28 Low Low
Sepsis 15 5.00 Very Low Very Low Very Low
Stroke 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 3 5.00 Very Low Very Low Very Low
Heart Rate Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of naloxone on the inhibitory effect of melatonin on the release of arginine-vasopressin induced by physical exercise in man.
Negative_regulation (effect) of Positive_regulation (induced) of arginine-vasopressin associated with narcan
1) Confidence 0.43 Published 2010 Journal Regul. Pept. Section Title Doc Link 20346989 Disease Relevance 0 Pain Relevance 0.40
The data indicate that the narcotic antagonists are capable of inhibiting ADH release in man during ad libitum fluid intake and in response to an osmotic stimulus by elevating the osmotic threshold for ADH release.
Negative_regulation (inhibiting) of Positive_regulation (elevating) of ADH associated with antagonist
2) Confidence 0.43 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6103008 Disease Relevance 0 Pain Relevance 0.54
Naloxone both reduced resting levels of vasopressin and inhibited the rise in vasopressin induced by an orthostatic stimulus.
Negative_regulation (inhibited) of Positive_regulation (induced) of vasopressin associated with narcan
3) Confidence 0.42 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7358835 Disease Relevance 0 Pain Relevance 0.51
Tetrodotoxin, administered to the PVH via osmotic minipump, blocked the stress-induced rise in CRF and AVP mRNAs, but had no significant effect on basal levels of these transcripts.
Negative_regulation (blocked) of Positive_regulation (rise) of AVP in PVH associated with stress and tetrodotoxin
4) Confidence 0.41 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8401558 Disease Relevance 0.32 Pain Relevance 0.25
In addition, the AVP-associated increase in PVRI was attenuated by dobutamine (p = 0.064; AVP-Dobu versus AVP group at dobutamine 10 ?
Negative_regulation (attenuated) of Positive_regulation (increase) of AVP-associated
5) Confidence 0.41 Published 2006 Journal Crit Care Section Body Doc Link PMC1751059 Disease Relevance 0.06 Pain Relevance 0
Inhibition of vasopressin-sensitive cAMP accumulation by alpha 2-adrenoceptor agonists in collecting tubules is species dependent.
Negative_regulation (Inhibition) of Positive_regulation (accumulation) of vasopressin in collecting tubules associated with agonist
6) Confidence 0.32 Published 1992 Journal Pharmacology Section Title Doc Link 1348126 Disease Relevance 0 Pain Relevance 0.27

General Comments

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