INT73754

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.66
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
sciatic nerve 2
dorsal root ganglia 2
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 3 100.00 Very High Very High Very High
dorsal root ganglion 5 99.68 Very High Very High Very High
Eae 4 98.84 Very High Very High Very High
Sciatic nerve 3 98.66 Very High Very High Very High
Inflammation 2 95.48 Very High Very High Very High
Pain 4 94.72 High High
sodium channel 5 93.92 High High
Spinal cord 1 93.20 High High
tetrodotoxin 8 90.72 High High
Potency 1 84.80 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 99.68 Very High Very High Very High
Injury 6 98.84 Very High Very High Very High
INFLAMMATION 3 95.48 Very High Very High Very High
Arthralgia 2 94.96 High High
Pain 1 92.60 High High
Nociception 1 91.00 High High
Inflammatory Pain 2 82.80 Quite High
Neuropathic Pain 3 78.60 Quite High
Hypersensitivity 1 40.20 Quite Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess further the role of PN3, we have used electrophysiological, in situ hybridization and immunohistochemical methods to monitor changes in TTXR sodium current and the distribution of PN3 in normal and peripheral nerve-injured rats. (1) Whole-cell patch-clamp recordings showed that there were no significant changes in the TTXR and TTX-sensitive sodium current densities of small DRG neurons after chronic constriction injury (CCI) of the sciatic nerve. (2) Additionally, in situ hybridization showed that there was no change in the expression of PN3 mRNA in the DRG up to 14 d after CCI.
Neg (no) Regulation (change) of Gene_expression (expression) of PN3 mRNA in sciatic nerve associated with dorsal root ganglion, eae, injury and sciatic nerve
1) Confidence 0.62 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482802 Disease Relevance 0.99 Pain Relevance 0.89
In this study, whole-cell patch-clamp techniques were used to determine the effects of ranolazine on human Na(V)1.7 (hNa(V)1.7 + beta(1) subunits) and rat Na(V)1.8 (rNa(V)1.8) channels expressed in HEK293 and ND7-23 cells, respectively.
Regulation (effects) of Gene_expression (expressed) of Na(V)1.8
2) Confidence 0.26 Published 2008 Journal Channels (Austin) Section Abstract Doc Link 19077543 Disease Relevance 0.09 Pain Relevance 0.46
Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain.
Regulation (Changes) of Gene_expression (expression) of NaV1.8 in dorsal root ganglia associated with pain, arthralgia, inflammation and neuropeptide
3) Confidence 0.17 Published 2008 Journal Eur J Pain Section Title Doc Link 17950013 Disease Relevance 0.57 Pain Relevance 0.79

General Comments

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