INT73760

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Context Info
Confidence 0.72
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 2.11
Pain Relevance 7.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 4
nucleus accumbens 2
substantia nigra 1
neuronal 1
neurons 1
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 681 100.00 Very High Very High Very High
dopamine receptor 21 99.98 Very High Very High Very High
Enkephalin 30 99.80 Very High Very High Very High
Nucleus accumbens 68 99.68 Very High Very High Very High
Morphine 14 97.26 Very High Very High Very High
substance P 14 96.48 Very High Very High Very High
Ventral tegmentum 41 95.24 Very High Very High Very High
Substantia nigra 50 95.20 Very High Very High Very High
midbrain 81 94.08 High High
Dynorphin 30 92.96 High High
Disease Link Frequency Relevance Heat
Schizophrenia 20 96.88 Very High Very High Very High
Cv Unclassified Under Development 1 86.60 High High
Dystonia 10 85.12 High High
Drug Dependence 6 80.20 Quite High
Hypertrophy 12 77.68 Quite High
Hypoxia 5 77.60 Quite High
Cognitive Disorder 20 75.84 Quite High
Death 40 75.16 Quite High
Opiate Addiction 2 74.92 Quite High
Attention Deficit Hyperactivity Disorder 164 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of D1R and D2R mRNA expression by quantitative RT-PCR in the striatum at prenatal and early postnatal stages (embryonic day 14 to postnatal day 7) revealed that at E14, the D2R was predominant over the D1R in the striatum (Araki et al., 2007).
Transcription (expression) of D2R in striatum
1) Confidence 0.72 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.04
Effects of single (20 mg/kg i.p.) and repeated morphine administration (increasing doses: from 10 to 50 mg/kg i.p. twice daily for 7 days) on the proenkephalin (PENK), prodynorphin (PDYN) and dopamine D2 receptor (D2) mRNA levels in the nucleus accumbens and striatum of the mouse were investigated.
Transcription (levels) of dopamine D2 receptor in striatum associated with nucleus accumbens, dopamine and morphine
2) Confidence 0.60 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.70
Moreover, the loss of DA innervation caused by 6-hydroxydopamine (6-OHDA) increased the expression of mRNAs encoding the D2R and enkephalin selectively in striatopallidal MSNs, whereas mRNAs encoding the D1R and substance P were only decreased in striatonigral MSNs (Gerfen et al., 1990).
Transcription (expression) of D2R associated with dopamine, enkephalin and substance p
3) Confidence 0.53 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.57
In contrast striatal mRNA expression levels for DRD2 and PPE did not differ between control and mutant animals (Fig. 5A and B).
Transcription (levels) of DRD2
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.61
Striatal mRNA levels for PPE, PDyn, and DRD1 and DRD2 receptors revealed a significant change in the expression of markers present in medium spiny neurons projecting to the substantia nigra (direct pathway).
Transcription (levels) of DRD2 in substantia nigra associated with substantia nigra
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.37
In contrast striatal mRNA expression levels for DRD2 and PPE did not differ between control and mutant animals (Fig. 5A and B).
Transcription (expression) of DRD2
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.61
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
Transcription (levels) of D2 in neuronal associated with dopamine receptor
7) Confidence 0.38 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.13 Pain Relevance 0.43
However, DRD1 and DRD2 mRNA levels were increased in the striatum suggesting impaired release of dopamine [185].
Transcription (levels) of DRD2 in striatum associated with dopamine
8) Confidence 0.36 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.93 Pain Relevance 0.65
The D2 receptor upregulation caused by chronic antipsychotic exposure was described in both animals (Burt et al., 1977; Ginovart et al., 2009) and patients with schizophrenia (Lee et al., 1978; Mackay et al., 1982) and now is thought to be responsible for loss of efficacy of antipsychotics.
Transcription (described) of D2 receptor associated with schizophrenia
9) Confidence 0.22 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.10 Pain Relevance 0
In situ hybridization histochemistry was used to study mRNA expression levels of dopamine (e.g., D2 receptor, dopamine transporter) and opioid (e.g., proenkephalin) related markers in various structures in relation to brain pH.
Transcription (expression) of D2 receptor in brain
10) Confidence 0.22 Published 2006 Journal Brain Res. Bull. Section Body Doc Link 16861111 Disease Relevance 0.31 Pain Relevance 0
Effects of single (20 mg/kg i.p.) and repeated morphine administration (increasing doses: from 10 to 50 mg/kg i.p. twice daily for 7 days) on the proenkephalin (PENK), prodynorphin (PDYN) and dopamine D2 receptor (D2) mRNA levels in the nucleus accumbens and striatum of the mouse were investigated.
Transcription (levels) of dopamine D2 receptor in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
11) Confidence 0.20 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.70
In the striatum and nucleus accumbens, expression of PPT mRNA was elevated but PPE-A mRNA, D-1, D-2 receptor, and nNOS mRNA were not changed in hph-1 mice compared to controls.
Transcription (changed) of D-2 receptor in nucleus accumbens associated with nucleus accumbens
12) Confidence 0.19 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.32 Pain Relevance 0.55
In the striatum and nucleus accumbens, expression of PPT mRNA was elevated but PPE-A mRNA, D-1, D-2 receptor, and nNOS mRNA were not changed in hph-1 mice compared to controls.
Transcription (changed) of D-2 receptor in striatum associated with nucleus accumbens
13) Confidence 0.07 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.32 Pain Relevance 0.55
Only a small subpopulation (2-5%) of the neurons that contained dopamine D1 receptor mRNA also expressed dopamine D2 receptor mRNA in all regions.
Transcription (expressed) of D2 receptor in neurons associated with dopamine
14) Confidence 0.04 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10701753 Disease Relevance 0 Pain Relevance 0.74
Preproenkephalin messenger RNA was identified in 46% of the neurons innervating the ventral pallidum, and D2 receptor messenger RNA was found in approximately 40% of the cells.
Transcription (found) of D2 receptor in pallidum
15) Confidence 0.01 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483534 Disease Relevance 0 Pain Relevance 0.66

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