INT73775

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.68
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1, GHR) extracellular region (GH1, GHR) mitochondrion (GHR)
plasma membrane (GHR) nucleus (GHR) cytoplasm (GHR)
Anatomy Link Frequency
liver 1
lymphocytes 1
GH1 (Homo sapiens)
GHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 6 99.92 Very High Very High Very High
opioid receptor 2 96.92 Very High Very High Very High
narcan 3 93.44 High High
Opioid 1 68.92 Quite High
headache 3 52.80 Quite High
Clonidine 10 13.04 Low Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 42 99.04 Very High Very High Very High
Renal Disease 5 96.34 Very High Very High Very High
Syndrome 6 91.76 High High
Immunization 8 67.68 Quite High
Headache 3 52.80 Quite High
Pressure And Volume Under Development 3 51.76 Quite High
Appetite Loss 7 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In healthy individuals, the kidney accounts for about 50% of the total MCR,23 and it is less than this in patients with renal disease,24 whereas extrarenal elimination (mostly via the liver) does not seem to differ significantly between the two groups.23 However, the situation is made more complex by the fact that GH also exists (reversibly) bound to GHBP, which is decreased in ESRD patients; the relative amounts of bound GH will most likely also correlate with the GH elimination rate.
GH Binding (bound) of GHBP in liver associated with chronic renal failure and renal disease
1) Confidence 0.35 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.52 Pain Relevance 0.05
The present study demonstrates, for the first time, effects of morphine on GHR mRNA levels and [125I]GH binding in human cultured lymphocytes.
GH Binding (binding) of GHR mRNA in lymphocytes associated with morphine
2) Confidence 0.21 Published 1997 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9484910 Disease Relevance 0 Pain Relevance 0.74
for the binding of hGH to the human GH receptor (hGHR) [15]
hGH Binding (binding) of hGHR
3) Confidence 0.03 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0 Pain Relevance 0
have reported on the importance of binding sites 1 and 2 of hGH molecule to dimerization of hGHR;
hGH Binding (dimerization) of hGHR
4) Confidence 0.02 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.16 Pain Relevance 0

General Comments

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