INT7378
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The number of EFs decreased further and their arrangement was more deranged at 8 weeks. | |||||||||||||||
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3 mol/L has significantly reduced EFS-evoked contractile responses but not the carbachol-induced ones. | |||||||||||||||
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3 mol/L) reduced EFS-evoked contractile responses significantly. | |||||||||||||||
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The hypercontractile responses of detrusor strips to carbachol, EFS and KCl were abolished by treatment with both fluoxetine and sertraline. | |||||||||||||||
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Our results suggest that the possible mechanism responsible for inhibition of tracheal inhibitory responses to EFS in ethanol-dependent rats may be a reduction in production of NO and in the uptake of L-arginine. | |||||||||||||||
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PGE2 inhibited EFS to a larger extent than NS; we postulate a possible excitatory effect of PGE2 on neurotransmission in the airway ganglia. | |||||||||||||||
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PGE2 (1-50 mM) produced a concentration-dependent inhibition of NS and EFS without affecting responses to exogenous acetylcholine (ACh). | |||||||||||||||
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The NK1 receptor selective antagonist, SR 140,333 (0.1 microM for 60 min) and the NK2 receptor selective antagonist, MEN 10,627 (0.1 microM for 60 min), both produced a partial inhibition of the contractile response to EFS. | |||||||||||||||
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The co-administration of SR 140,333 and MEN 10,627 nearly abolished the NANC contraction to EFS in the ileum. 4. | |||||||||||||||
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The contractile response of the aortic preparation to EFS was also considerably reduced by the removal of the endothelium. | |||||||||||||||
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Ginger (0.01-1000 microg/ml) inhibited both EFS- and acetylcholine-evoked contractions, being more potent in inhibiting the contractions induced by EFS. | |||||||||||||||
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The threshold concentration of clonidine to inhibit EFS contractions was lower in the fundus than in the antrum. | |||||||||||||||
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The threshold concentration of amitriptyline to inhibit EFS contractions was lower in the antrum than in the fundus. | |||||||||||||||
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Amitriptyline inhibits gastric contractility to EFS and ACh suggesting an inhibitory muscle effect. | |||||||||||||||
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Tetrodotoxin (5 X 10(-6) mol l-1) fully suppressed the contractile responses to EFS. | |||||||||||||||
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The EFS induced relaxation response was inhibited by an inhibitor of nitric oxide biosynthesis, NG-nitro-L-arginine. | |||||||||||||||
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The following results were obtained: (i) subthreshold doses of U-46619 (10(-10) M and 10(-9) M) significantly increased the amplitude of the contractions evoked by EFS; (ii) by contrast, U-46619 had no effect on the contractile response of smooth muscle to exogenously applied ACh; (iii) the contraction evoked by EFS was completely abolished by the application of atropine (10(-6) M) or tetrodotoxin (10(-7) M), indicating that EFS caused the smooth muscle contraction through the release of ACh from vagal nerve terminals; and (iv) pretreatment with BAY u3405 (10(-6) M) abolished the excitatory action of U-46619 on the amplitude of twitch contraction evoked by EFS in the trachea. | |||||||||||||||
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TTX almost abolished the IAS responses to EFS. | |||||||||||||||
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After blockade of autoinhibition by atropine, the peptides also inhibited EFS-evoked ACh release at 10 Hz. | |||||||||||||||
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In the presence of atropine, which blocks the autoinhibition, non-selective K+ channel blockers, tetraethylammonium (TEA) and 4-aminopyridine (4-AP), reversed the inhibitory effect of mu-agonists, morphine and [D-Ala2, N-Me-Phe4, Gly5-ol] enkephalin, on EFS-evoked ACh release, but not that of kappa-agonist U-50,488. | |||||||||||||||
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General Comments
This test has worked.