INT7378

Context Info Confidence 0.37 First Reported 1988 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 17 Total Number 20 Disease Relevance 1.93 Pain Relevance 7.78

Anatomy Link Frequency fundus 2 ileum 1 IAS 1 muscle 1 endothelium 1 Efs (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 12 100.00 Morphine 2 100.00 Enkephalin 1 100.00 Endep 18 99.98 Clonidine 24 99.92 tetrodotoxin 24 99.84 Serotonin 2 99.68 fluoxetine 5 99.04 antagonist 20 98.88 depression 2 95.28

Disease Link Frequency Relevance Heat Overactive Bladder 65 99.56 Depression 2 95.28 Sleep Disorders 18 95.08 Ganglion Cysts 2 94.36 Diarrhoea 1 91.92 Vomiting 1 91.36 Dyspepsia 1 91.04 Gastrointestinal Disease 1 90.20 Temporomandibular Joint Syndrome 2 61.68 Stress Incontinence 2 53.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The number of EFs decreased further and their arrangement was more deranged at 8 weeks.

Negative_regulation (decreased) of EFs

1) Confidence 0.37 Published 2002 Journal Chin. Med. J. Section Body Doc Link 12622921 Disease Relevance 0.06 Pain Relevance 0

3 mol/L has significantly reduced EFS-evoked contractile responses but not the carbachol-induced ones.

Negative_regulation (reduced) of EFS

2) Confidence 0.37 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2978435 Disease Relevance 0.29 Pain Relevance 0.32

3 mol/L) reduced EFS-evoked contractile responses significantly.

Negative_regulation (reduced) of EFS

3) Confidence 0.37 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2978435 Disease Relevance 0.27 Pain Relevance 0.26

The hypercontractile responses of detrusor strips to carbachol, EFS and KCl were abolished by treatment with both fluoxetine and sertraline.

Negative_regulation (abolished) of EFS associated with overactive bladder and fluoxetine

4) Confidence 0.35 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211979 Disease Relevance 0.67 Pain Relevance 0.49

Our results suggest that the possible mechanism responsible for inhibition of tracheal inhibitory responses to EFS in ethanol-dependent rats may be a reduction in production of NO and in the uptake of L-arginine.

Spec (possible) Negative_regulation (inhibition) of EFS

5) Confidence 0.35 Published 2003 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 14565541 Disease Relevance 0 Pain Relevance 0.07

PGE2 inhibited EFS to a larger extent than NS; we postulate a possible excitatory effect of PGE2 on neurotransmission in the airway ganglia.

Negative_regulation (inhibited) of EFS in ganglia

6) Confidence 0.32 Published 1992 Journal Respir Physiol Section Abstract Doc Link 1348147 Disease Relevance 0.09 Pain Relevance 0.07

PGE2 (1-50 mM) produced a concentration-dependent inhibition of NS and EFS without affecting responses to exogenous acetylcholine (ACh).

Negative_regulation (inhibition) of EFS in PGE2

7) Confidence 0.32 Published 1992 Journal Respir Physiol Section Abstract Doc Link 1348147 Disease Relevance 0.09 Pain Relevance 0.08

The NK1 receptor selective antagonist, SR 140,333 (0.1 microM for 60 min) and the NK2 receptor selective antagonist, MEN 10,627 (0.1 microM for 60 min), both produced a partial inhibition of the contractile response to EFS.

Spec (partial) Negative_regulation (inhibition) of EFS associated with antagonist

8) Confidence 0.26 Published 1995 Journal J Auton Pharmacol Section Abstract Doc Link 8744974 Disease Relevance 0 Pain Relevance 0.42

The co-administration of SR 140,333 and MEN 10,627 nearly abolished the NANC contraction to EFS in the ileum. 4.

Negative_regulation (abolished) of EFS in ileum

9) Confidence 0.26 Published 1995 Journal J Auton Pharmacol Section Abstract Doc Link 8744974 Disease Relevance 0.10 Pain Relevance 0.38

The contractile response of the aortic preparation to EFS was also considerably reduced by the removal of the endothelium.

Negative_regulation (reduced) of EFS in endothelium

10) Confidence 0.23 Published 1998 Journal Fukushima J Med Sci Section Abstract Doc Link 9775528 Disease Relevance 0 Pain Relevance 0.14

Ginger (0.01-1000 microg/ml) inhibited both EFS- and acetylcholine-evoked contractions, being more potent in inhibiting the contractions induced by EFS.

Negative_regulation (inhibited) of EFS

11) Confidence 0.23 Published 2004 Journal Life Sci. Section Abstract Doc Link 15050426 Disease Relevance 0.36 Pain Relevance 0.30

The threshold concentration of clonidine to inhibit EFS contractions was lower in the fundus than in the antrum.

Negative_regulation (inhibit) of EFS in fundus associated with clonidine

12) Confidence 0.10 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15086868 Disease Relevance 0 Pain Relevance 1.23

The threshold concentration of amitriptyline to inhibit EFS contractions was lower in the antrum than in the fundus.

Negative_regulation (inhibit) of EFS in fundus associated with endep

13) Confidence 0.10 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15086868 Disease Relevance 0 Pain Relevance 1.24

Amitriptyline inhibits gastric contractility to EFS and ACh suggesting an inhibitory muscle effect.

Negative_regulation (inhibits) of EFS in muscle associated with endep

14) Confidence 0.10 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15086868 Disease Relevance 0 Pain Relevance 1.04

Tetrodotoxin (5 X 10(-6) mol l-1) fully suppressed the contractile responses to EFS.

Negative_regulation (suppressed) of EFS associated with tetrodotoxin

15) Confidence 0.10 Published 1990 Journal Exp. Physiol. Section Abstract Doc Link 2155625 Disease Relevance 0 Pain Relevance 0.38

The EFS induced relaxation response was inhibited by an inhibitor of nitric oxide biosynthesis, NG-nitro-L-arginine.

Negative_regulation (inhibited) of EFS

16) Confidence 0.08 Published 1994 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8121115 Disease Relevance 0 Pain Relevance 0.09

The following results were obtained: (i) subthreshold doses of U-46619 (10(-10) M and 10(-9) M) significantly increased the amplitude of the contractions evoked by EFS; (ii) by contrast, U-46619 had no effect on the contractile response of smooth muscle to exogenously applied ACh; (iii) the contraction evoked by EFS was completely abolished by the application of atropine (10(-6) M) or tetrodotoxin (10(-7) M), indicating that EFS caused the smooth muscle contraction through the release of ACh from vagal nerve terminals; and (iv) pretreatment with BAY u3405 (10(-6) M) abolished the excitatory action of U-46619 on the amplitude of twitch contraction evoked by EFS in the trachea.

Negative_regulation (abolished) of EFS in trachea associated with tetrodotoxin

17) Confidence 0.06 Published 1995 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7480085 Disease Relevance 0 Pain Relevance 0.17

TTX almost abolished the IAS responses to EFS.

Negative_regulation (abolished) of EFS in IAS associated with tetrodotoxin

18) Confidence 0.03 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2903675 Disease Relevance 0 Pain Relevance 0.38

After blockade of autoinhibition by atropine, the peptides also inhibited EFS-evoked ACh release at 10 Hz.

Negative_regulation (inhibited) of EFS-evoked

19) Confidence 0.00 Published 1998 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 9804067 Disease Relevance 0 Pain Relevance 0.18

In the presence of atropine, which blocks the autoinhibition, non-selective K+ channel blockers, tetraethylammonium (TEA) and 4-aminopyridine (4-AP), reversed the inhibitory effect of mu-agonists, morphine and [D-Ala2, N-Me-Phe4, Gly5-ol] enkephalin, on EFS-evoked ACh release, but not that of kappa-agonist U-50,488.

Negative_regulation (reversed) of EFS-evoked associated with agonist, enkephalin and morphine

20) Confidence 0.00 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10875755 Disease Relevance 0 Pain Relevance 0.54

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