INT73796

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.39
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR7) signal transducer activity (HTR7)
Anatomy Link Frequency
enterocytes 1
hypothalamus 1
myocytes 1
smooth muscles 1
nerves 1
HTR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 17 99.92 Very High Very High Very High
fluoxetine 9 99.82 Very High Very High Very High
antagonist 13 99.20 Very High Very High Very High
sSRI 1 98.12 Very High Very High Very High
Calcium channel 1 95.08 Very High Very High Very High
unmyelinated 2 94.60 High High
Kinase C 1 90.16 High High
Somatostatin 2 87.88 High High
spastic colon 27 85.84 High High
Sumatriptan 6 85.36 High High
Disease Link Frequency Relevance Heat
Cluster Headache 4 97.92 Very High Very High Very High
Gastrointestinal Disease 3 89.20 High High
Functional Bowel Disorder 6 85.84 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

21 83.76 Quite High
Impaired Glucose Tolerance 1 80.56 Quite High
Increased Venous Pressure Under Development 2 75.48 Quite High
Diarrhoea 9 73.36 Quite High
Hepatotoxicity 1 50.48 Quite High
Abdominal Pain 3 36.16 Quite Low
Dyspepsia 3 34.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar observations have now been made in human cortical tissue, in which the expected localization of the vascular 5-hydroxytryptamine1B receptor to periarteriolar myocytes was also confirmed.
Localization (localization) of 5-hydroxytryptamine in myocytes
1) Confidence 0.78 Published 1998 Journal Neuroscience Section Abstract Doc Link 9697110 Disease Relevance 0.22 Pain Relevance 0.27
Coadministration of 5-hydroxytryptamine(1A) antagonist WAY-100635 prevents fluoxetine-induced desensitization of postsynaptic 5-hydroxytryptamine(1A) receptors in hypothalamus.
Localization (desensitization) of 5-hydroxytryptamine in hypothalamus associated with antagonist and fluoxetine
2) Confidence 0.73 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10871325 Disease Relevance 0 Pain Relevance 0.50
-aminobutyric acid type A receptor (Hales and Lambert, 1991), whereas etomidate binds to the 5-hydroxytryptamine type 3 receptor (Appadu and Lambert, 1996), the ?
Localization (receptor) of 5-hydroxytryptamine
3) Confidence 0.73 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.05 Pain Relevance 0.12
From our study, we speculate that activation of the 5-hydroxytryptamine-1 receptor inhibits endocrine pancreatic secretion.
Localization (secretion) of 5-hydroxytryptamine
4) Confidence 0.68 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486164 Disease Relevance 0.08 Pain Relevance 0.57
Immunoelectron microscopic labeling of the 5-hydroxytryptamine1B receptor in rat brain parenchyma has revealed a distinct localization to the endothelium of microvessels, which was predominantly cytoplasmic as opposed to membrane-bound, contrary to that on preterminal unmyelinated axons [Riad et al. (1997) Soc.
Localization (localization) of 5-hydroxytryptamine in endothelium associated with unmyelinated
5) Confidence 0.68 Published 1998 Journal Neuroscience Section Abstract Doc Link 9697110 Disease Relevance 0.25 Pain Relevance 0.17
Serotonin is secreted by enterochromaffin (EC) cells and acts on receptors located on smooth muscles, enterocytes and nerves (5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT7).
Localization (secreted) of 5-HT7 in smooth muscles associated with serotonin
6) Confidence 0.68 Published 2007 Journal Wiad. Lek. Section Abstract Doc Link 18175558 Disease Relevance 0.32 Pain Relevance 0.74
Serotonin is secreted by enterochromaffin (EC) cells and acts on receptors located on smooth muscles, enterocytes and nerves (5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT7).
Localization (secreted) of 5-HT7 in enterocytes associated with serotonin
7) Confidence 0.23 Published 2007 Journal Wiad. Lek. Section Abstract Doc Link 18175558 Disease Relevance 0.32 Pain Relevance 0.74
Serotonin is secreted by enterochromaffin (EC) cells and acts on receptors located on smooth muscles, enterocytes and nerves (5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT7).
Localization (secreted) of 5-HT7 in nerves associated with serotonin
8) Confidence 0.23 Published 2007 Journal Wiad. Lek. Section Abstract Doc Link 18175558 Disease Relevance 0.32 Pain Relevance 0.74

General Comments

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