INT73797

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Context Info
Confidence 0.10
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.65
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (MIA3)
Anatomy Link Frequency
plasma 6
peripheral nerve 2
MIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 24 100.00 Very High Very High Very High
Sumatriptan 6 99.70 Very High Very High Very High
tolerance 6 94.60 High High
diabetic neuropathy 21 75.32 Quite High
Angina 6 72.64 Quite High
agonist 1 69.84 Quite High
Inflammation 36 65.92 Quite High
cytokine 24 52.52 Quite High
chemokine 18 48.32 Quite Low
Kinase C 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 326 99.86 Very High Very High Very High
Atherosclerosis 84 99.56 Very High Very High Very High
Hypoglycemia 184 98.72 Very High Very High Very High
Congenital Anomalies 24 97.28 Very High Very High Very High
Neuropathy 69 95.68 Very High Very High Very High
Hyperinsulinism 10 94.80 High High
Impaired Glucose Tolerance 4 94.60 High High
Nesidioblastosis 6 91.84 High High
Heart Rate Under Development 8 90.92 High High
Overdose 16 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
type 2 diabetes often become insulin and C-peptide deficient, and at this stage
Negative_regulation (become) of Gene_expression (deficient) of C-peptide associated with diabetes mellitus
1) Confidence 0.10 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 1.72 Pain Relevance 0.07
Sumatriptan significantly decreased the mean plasma levels of somatostatin, glucagon, pancreatic polypeptide, insulin and C-peptide (P < 0.001) and also significantly decreased mean and peak plasma levels of insulin after an oral glucose challenge (P < 0.02 and P = 0.04, respectively) without affecting glucose homeostasis.
Negative_regulation (decreased) of Gene_expression (levels) of C-peptide in plasma associated with sumatriptan and somatostatin
2) Confidence 0.10 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486164 Disease Relevance 0.09 Pain Relevance 0.69
peripheral nerve dysfunction following C-peptide administration in patients with type 1
Negative_regulation (following) of Gene_expression (administration) of C-peptide in peripheral nerve
3) Confidence 0.09 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.36 Pain Relevance 0
reference value 24%) and during the C-peptide infusion which restored plasma concentrations
Negative_regulation (restored) of Gene_expression (infusion) of C-peptide in plasma
4) Confidence 0.09 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.41 Pain Relevance 0
Both the interventions slightly improved proinsulin and C-peptide levels.
Negative_regulation (improved) of Gene_expression (levels) of C-peptide
5) Confidence 0.06 Published 2010 Journal The British Journal of Nutrition Section Body Doc Link PMC2943747 Disease Relevance 0.51 Pain Relevance 0
hypothesis was raised that C-peptide may deposit in the vessel wall during
Negative_regulation (raised) of Gene_expression (deposit) of C-peptide
6) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.58 Pain Relevance 0
Some of the diabetic subjects also exhibited C-peptide deposition
Negative_regulation (exhibited) of Gene_expression (deposition) of C-peptide associated with diabetes mellitus
7) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 1.01 Pain Relevance 0.12
A regimen of octreotide administration similar to that reported by Krentz and coworkers allowed euglycaemia to be maintained, without need for additional dextrose support, by decreasing plasma insulin and C-peptide levels.
Negative_regulation (decreasing) of Gene_expression (levels) of C-peptide in plasma
8) Confidence 0.04 Published 2005 Journal Crit Care Section Body Doc Link PMC1414034 Disease Relevance 0.91 Pain Relevance 0
In this case, marked reductions in insulin and C-peptide levels were documented (before octreotide treatment: insulin 1250 pmol/l and C-peptide 20,949 pmol/l; 8 hours after octreotide treatment: insulin 153 pmol/l and C-peptide 5654 pmol/l).
Negative_regulation (reductions) of Gene_expression (levels) of C-peptide
9) Confidence 0.04 Published 2005 Journal Crit Care Section Body Doc Link PMC1414034 Disease Relevance 1.05 Pain Relevance 0
revealed significantly higher C-peptide deposition in lesions from diabetic
Negative_regulation (revealed) of Gene_expression (deposition) of C-peptide associated with diabetes mellitus
10) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.99 Pain Relevance 0.06
In contrast, only very little C-peptide deposition has been found
Neg (little) Negative_regulation (little) of Gene_expression (deposition) of C-peptide
11) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 1.04 Pain Relevance 0.12
in youth) revealed C-peptide deposition mainly in the subendothelial space and
Negative_regulation (revealed) of Gene_expression (deposition) of C-peptide
12) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 1.03 Pain Relevance 0.16
effects of C-peptide on SMCs were inhibited by a specific inhibitor of
Negative_regulation (inhibited) of Gene_expression (effects) of C-peptide
13) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.43 Pain Relevance 0.03
Rapid determination of insulin levels with detection of C-peptide is a new modality for diagnosing insulinoma.
Negative_regulation (determination) of Gene_expression (detection) of C-peptide associated with hypoglycemia
14) Confidence 0.03 Published 2007 Journal Ann Surg Innov Res Section Body Doc Link PMC2116998 Disease Relevance 0.51 Pain Relevance 0

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